D030056L22Rik protein (mouse) - STRING interaction network

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D030056L22Rik

Uncharacterized protein C9orf40 homolog. (162 aa)

Predicted Functional Partners:

Naa40

0.528

Cdc37l1

0.491

Pak1ip1

0.450

Zfp367

0.440

Plekha3

0.436

Tbc1d9

0.431

Nkiras1

0.412

Enpp5

0.410

St6galnac6

0.410

Your Current Organism:

Mus musculus

NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Cdc37l1	D030056L22Rik	ENSMUSP00000060421	ENSMUSP00000061933	Hsp90 co-chaperone Cdc37-like 1; Co-chaperone that binds to numerous proteins and promotes their interaction with Hsp70 and Hsp90; Belongs to the CDC37 family.	Uncharacterized protein C9orf40 homolog.	0.491
Cdc37l1	Pak1ip1	ENSMUSP00000060421	ENSMUSP00000040846	Hsp90 co-chaperone Cdc37-like 1; Co-chaperone that binds to numerous proteins and promotes their interaction with Hsp70 and Hsp90; Belongs to the CDC37 family.	P21-activated protein kinase-interacting protein 1; Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which has been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42. May be involved in ribosomal large subunit assembly.	0.423
Cdc37l1	Plekha3	ENSMUSP00000060421	ENSMUSP00000107551	Hsp90 co-chaperone Cdc37-like 1; Co-chaperone that binds to numerous proteins and promotes their interaction with Hsp70 and Hsp90; Belongs to the CDC37 family.	Pleckstrin homology domain-containing family A member 3; Involved in Golgi to cell surface membrane traffic. Induces membrane tubulation. Binds preferentially to phosphatidylinositol 4- phosphate (PtdIns4P) (By similarity).	0.576
D030056L22Rik	Cdc37l1	ENSMUSP00000061933	ENSMUSP00000060421	Uncharacterized protein C9orf40 homolog.	Hsp90 co-chaperone Cdc37-like 1; Co-chaperone that binds to numerous proteins and promotes their interaction with Hsp70 and Hsp90; Belongs to the CDC37 family.	0.491
D030056L22Rik	Enpp5	ENSMUSP00000061933	ENSMUSP00000024756	Uncharacterized protein C9orf40 homolog.	Ectonucleotide pyrophosphatase/phosphodiesterase family member 5; Can hydrolyze NAD but cannot hydrolyze nucleotide di- and triphosphates. Lacks lysopholipase D activity. May play a role in neuronal cell communication (By similarity).	0.410
D030056L22Rik	Naa40	ENSMUSP00000061933	ENSMUSP00000025675	Uncharacterized protein C9orf40 homolog.	N-alpha-acetyltransferase 40; N-alpha-acetyltransferase that specifically mediates the acetylation of the N-terminal residues of histones H4 and H2A (By similarity). In contrast to other N-alpha-acetyltransferase, has a very specific selectivity for histones H4 and H2A N-terminus and specifically recognizes the 'Ser-Gly-Arg-Gly sequence' (By similarity). Acts as a negative regulator of apoptosis (By similarity). May play a role in hepatic lipid metabolism. Belongs to the acetyltransferase family. NAA40 subfamily.	0.528
D030056L22Rik	Nkiras1	ENSMUSP00000061933	ENSMUSP00000121496	Uncharacterized protein C9orf40 homolog.	NF-kappa-B inhibitor-interacting Ras-like protein 1; Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB (By similarity); Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.	0.412
D030056L22Rik	Pak1ip1	ENSMUSP00000061933	ENSMUSP00000040846	Uncharacterized protein C9orf40 homolog.	P21-activated protein kinase-interacting protein 1; Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which has been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42. May be involved in ribosomal large subunit assembly.	0.450
D030056L22Rik	Plekha3	ENSMUSP00000061933	ENSMUSP00000107551	Uncharacterized protein C9orf40 homolog.	Pleckstrin homology domain-containing family A member 3; Involved in Golgi to cell surface membrane traffic. Induces membrane tubulation. Binds preferentially to phosphatidylinositol 4- phosphate (PtdIns4P) (By similarity).	0.436
D030056L22Rik	St6galnac6	ENSMUSP00000061933	ENSMUSP00000092654	Uncharacterized protein C9orf40 homolog.	Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; Alpha-2,6-sialyltransferase involved in the synthesis of alpha-series gangliosides. Has activity toward GD1a, GT1b and GM1b. Has no activity toward glycoproteins. Responsible for the biosynthesis of DSGG (disialylgalactosylgloboside) from MSGG (monosialylgalactosylgloboside) in kidney.	0.410
D030056L22Rik	Tbc1d9	ENSMUSP00000061933	ENSMUSP00000091093	Uncharacterized protein C9orf40 homolog.	TBC1 domain family member 9; May act as a GTPase-activating protein for Rab family protein(s).	0.431
D030056L22Rik	Zfp367	ENSMUSP00000061933	ENSMUSP00000050854	Uncharacterized protein C9orf40 homolog.	Zinc finger protein 367; Transcriptional activator. Isoform 1 may be involved in transcriptional activation of erythroid genes (By similarity).	0.440
Enpp5	D030056L22Rik	ENSMUSP00000024756	ENSMUSP00000061933	Ectonucleotide pyrophosphatase/phosphodiesterase family member 5; Can hydrolyze NAD but cannot hydrolyze nucleotide di- and triphosphates. Lacks lysopholipase D activity. May play a role in neuronal cell communication (By similarity).	Uncharacterized protein C9orf40 homolog.	0.410
Naa40	D030056L22Rik	ENSMUSP00000025675	ENSMUSP00000061933	N-alpha-acetyltransferase 40; N-alpha-acetyltransferase that specifically mediates the acetylation of the N-terminal residues of histones H4 and H2A (By similarity). In contrast to other N-alpha-acetyltransferase, has a very specific selectivity for histones H4 and H2A N-terminus and specifically recognizes the 'Ser-Gly-Arg-Gly sequence' (By similarity). Acts as a negative regulator of apoptosis (By similarity). May play a role in hepatic lipid metabolism. Belongs to the acetyltransferase family. NAA40 subfamily.	Uncharacterized protein C9orf40 homolog.	0.528
Nkiras1	D030056L22Rik	ENSMUSP00000121496	ENSMUSP00000061933	NF-kappa-B inhibitor-interacting Ras-like protein 1; Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB (By similarity); Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.	Uncharacterized protein C9orf40 homolog.	0.412
Nkiras1	Plekha3	ENSMUSP00000121496	ENSMUSP00000107551	NF-kappa-B inhibitor-interacting Ras-like protein 1; Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB (By similarity); Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.	Pleckstrin homology domain-containing family A member 3; Involved in Golgi to cell surface membrane traffic. Induces membrane tubulation. Binds preferentially to phosphatidylinositol 4- phosphate (PtdIns4P) (By similarity).	0.447
Pak1ip1	Cdc37l1	ENSMUSP00000040846	ENSMUSP00000060421	P21-activated protein kinase-interacting protein 1; Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which has been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42. May be involved in ribosomal large subunit assembly.	Hsp90 co-chaperone Cdc37-like 1; Co-chaperone that binds to numerous proteins and promotes their interaction with Hsp70 and Hsp90; Belongs to the CDC37 family.	0.423
Pak1ip1	D030056L22Rik	ENSMUSP00000040846	ENSMUSP00000061933	P21-activated protein kinase-interacting protein 1; Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which has been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42. May be involved in ribosomal large subunit assembly.	Uncharacterized protein C9orf40 homolog.	0.450
Pak1ip1	Plekha3	ENSMUSP00000040846	ENSMUSP00000107551	P21-activated protein kinase-interacting protein 1; Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which has been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42. May be involved in ribosomal large subunit assembly.	Pleckstrin homology domain-containing family A member 3; Involved in Golgi to cell surface membrane traffic. Induces membrane tubulation. Binds preferentially to phosphatidylinositol 4- phosphate (PtdIns4P) (By similarity).	0.492
Plekha3	Cdc37l1	ENSMUSP00000107551	ENSMUSP00000060421	Pleckstrin homology domain-containing family A member 3; Involved in Golgi to cell surface membrane traffic. Induces membrane tubulation. Binds preferentially to phosphatidylinositol 4- phosphate (PtdIns4P) (By similarity).	Hsp90 co-chaperone Cdc37-like 1; Co-chaperone that binds to numerous proteins and promotes their interaction with Hsp70 and Hsp90; Belongs to the CDC37 family.	0.576