node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Arhgap12 | Lhfpl2 | ENSMUSP00000138585 | ENSMUSP00000062239 | Rho GTPase-activating protein 12; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. | LHFPL tetraspan subfamily member 2 protein; Plays a role in female and male fertility. Involved in distal reproductive tract development. | 0.474 |
Arhgap12 | Rnf182 | ENSMUSP00000138585 | ENSMUSP00000062005 | Rho GTPase-activating protein 12; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. | E3 ubiquitin-protein ligase RNF182; E3 ubiquitin-protein ligase that mediates the ubiquitination of ATP6V0C and targets it to degradation via the ubiquitin-proteasome pathway. Plays also a role in the inhibition of TLR-triggered innate immune response by mediating 'Lys'-48-linked ubiquitination and subsequent degradation of NF-kappa-B component RELA. | 0.477 |
Arhgap12 | Tbc1d30 | ENSMUSP00000138585 | ENSMUSP00000070488 | Rho GTPase-activating protein 12; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. | TBC1 domain family member 30; GTPase-activating protein (GAP) with broad specificity. Acts as a GAP for RAB3A. Also exhibits significant GAP activity toward RAB22A, RAB27A, and RAB35 in vitro (By similarity). | 0.481 |
Atp6v0c | Rnf182 | ENSMUSP00000024932 | ENSMUSP00000062005 | V-type proton ATPase 16 kDa proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. | E3 ubiquitin-protein ligase RNF182; E3 ubiquitin-protein ligase that mediates the ubiquitination of ATP6V0C and targets it to degradation via the ubiquitin-proteasome pathway. Plays also a role in the inhibition of TLR-triggered innate immune response by mediating 'Lys'-48-linked ubiquitination and subsequent degradation of NF-kappa-B component RELA. | 0.465 |
Gid4 | Rnf182 | ENSMUSP00000064926 | ENSMUSP00000062005 | Glucose-induced degradation protein 4 homolog; Substrate-recognition subunit of the CTLH E3 ubiquitin- protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. Binds proteins and peptides with a Pro/N-degron consisting of an unmodified N-terminal Pro followed by a small residue, and has the highest affinity for the peptide Pro-Gly- Leu-Trp. Binds peptides with an N-terminal sequence of the type Pro- [Ala,Gly]-[Leu,Met,Gln,Ser,Tyr]-[Glu,Gly,His,Ser,Val,Trp,Tyr]. Does not bind [...] | E3 ubiquitin-protein ligase RNF182; E3 ubiquitin-protein ligase that mediates the ubiquitination of ATP6V0C and targets it to degradation via the ubiquitin-proteasome pathway. Plays also a role in the inhibition of TLR-triggered innate immune response by mediating 'Lys'-48-linked ubiquitination and subsequent degradation of NF-kappa-B component RELA. | 0.580 |
Lhfpl2 | Arhgap12 | ENSMUSP00000062239 | ENSMUSP00000138585 | LHFPL tetraspan subfamily member 2 protein; Plays a role in female and male fertility. Involved in distal reproductive tract development. | Rho GTPase-activating protein 12; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. | 0.474 |
Lhfpl2 | Nrip3 | ENSMUSP00000062239 | ENSMUSP00000033331 | LHFPL tetraspan subfamily member 2 protein; Plays a role in female and male fertility. Involved in distal reproductive tract development. | Nuclear receptor-interacting protein 3. | 0.407 |
Lhfpl2 | Ociad2 | ENSMUSP00000062239 | ENSMUSP00000084445 | LHFPL tetraspan subfamily member 2 protein; Plays a role in female and male fertility. Involved in distal reproductive tract development. | OCIA domain-containing protein 2. | 0.514 |
Lhfpl2 | Rnf182 | ENSMUSP00000062239 | ENSMUSP00000062005 | LHFPL tetraspan subfamily member 2 protein; Plays a role in female and male fertility. Involved in distal reproductive tract development. | E3 ubiquitin-protein ligase RNF182; E3 ubiquitin-protein ligase that mediates the ubiquitination of ATP6V0C and targets it to degradation via the ubiquitin-proteasome pathway. Plays also a role in the inhibition of TLR-triggered innate immune response by mediating 'Lys'-48-linked ubiquitination and subsequent degradation of NF-kappa-B component RELA. | 0.598 |
Lhfpl2 | Tbc1d30 | ENSMUSP00000062239 | ENSMUSP00000070488 | LHFPL tetraspan subfamily member 2 protein; Plays a role in female and male fertility. Involved in distal reproductive tract development. | TBC1 domain family member 30; GTPase-activating protein (GAP) with broad specificity. Acts as a GAP for RAB3A. Also exhibits significant GAP activity toward RAB22A, RAB27A, and RAB35 in vitro (By similarity). | 0.589 |
Nrip3 | Lhfpl2 | ENSMUSP00000033331 | ENSMUSP00000062239 | Nuclear receptor-interacting protein 3. | LHFPL tetraspan subfamily member 2 protein; Plays a role in female and male fertility. Involved in distal reproductive tract development. | 0.407 |
Nrip3 | Ociad2 | ENSMUSP00000033331 | ENSMUSP00000084445 | Nuclear receptor-interacting protein 3. | OCIA domain-containing protein 2. | 0.525 |
Nrip3 | Rnf182 | ENSMUSP00000033331 | ENSMUSP00000062005 | Nuclear receptor-interacting protein 3. | E3 ubiquitin-protein ligase RNF182; E3 ubiquitin-protein ligase that mediates the ubiquitination of ATP6V0C and targets it to degradation via the ubiquitin-proteasome pathway. Plays also a role in the inhibition of TLR-triggered innate immune response by mediating 'Lys'-48-linked ubiquitination and subsequent degradation of NF-kappa-B component RELA. | 0.466 |
Nrip3 | Tbc1d30 | ENSMUSP00000033331 | ENSMUSP00000070488 | Nuclear receptor-interacting protein 3. | TBC1 domain family member 30; GTPase-activating protein (GAP) with broad specificity. Acts as a GAP for RAB3A. Also exhibits significant GAP activity toward RAB22A, RAB27A, and RAB35 in vitro (By similarity). | 0.593 |
Ociad2 | Lhfpl2 | ENSMUSP00000084445 | ENSMUSP00000062239 | OCIA domain-containing protein 2. | LHFPL tetraspan subfamily member 2 protein; Plays a role in female and male fertility. Involved in distal reproductive tract development. | 0.514 |
Ociad2 | Nrip3 | ENSMUSP00000084445 | ENSMUSP00000033331 | OCIA domain-containing protein 2. | Nuclear receptor-interacting protein 3. | 0.525 |
Ociad2 | Rnf150 | ENSMUSP00000084445 | ENSMUSP00000077610 | OCIA domain-containing protein 2. | RING finger protein 150. | 0.444 |
Ociad2 | Rnf182 | ENSMUSP00000084445 | ENSMUSP00000062005 | OCIA domain-containing protein 2. | E3 ubiquitin-protein ligase RNF182; E3 ubiquitin-protein ligase that mediates the ubiquitination of ATP6V0C and targets it to degradation via the ubiquitin-proteasome pathway. Plays also a role in the inhibition of TLR-triggered innate immune response by mediating 'Lys'-48-linked ubiquitination and subsequent degradation of NF-kappa-B component RELA. | 0.526 |
Ociad2 | Tbc1d30 | ENSMUSP00000084445 | ENSMUSP00000070488 | OCIA domain-containing protein 2. | TBC1 domain family member 30; GTPase-activating protein (GAP) with broad specificity. Acts as a GAP for RAB3A. Also exhibits significant GAP activity toward RAB22A, RAB27A, and RAB35 in vitro (By similarity). | 0.528 |
Rnf150 | Ociad2 | ENSMUSP00000077610 | ENSMUSP00000084445 | RING finger protein 150. | OCIA domain-containing protein 2. | 0.444 |