| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Alpk1 | Ap1ar | ENSMUSP00000029662 | ENSMUSP00000059669 | Alpha-protein kinase 1; Serine/threonine-protein kinase that detects bacterial pathogen-associated molecular pattern metabolites (PAMPs) and initiates an innate immune response, a critical step for pathogen elimination and engagement of adaptive immunity (By similarity). Specifically recognizes and binds ADP-D-glycero-beta-D-manno-heptose (ADP-Heptose), a potent PAMP present in all Gram-negative and some Gram-positive bacteria. ADP-Heptose-binding stimulates its kinase activity to phosphorylate and activate TIFA, triggering proinflammatory NF-kappa-B signaling (By similarity). May be i [...] | Adaptor-related protein complex 1-associated regulatory protein. | 0.434 |
| Alpk1 | Fam241a | ENSMUSP00000029662 | ENSMUSP00000142535 | Alpha-protein kinase 1; Serine/threonine-protein kinase that detects bacterial pathogen-associated molecular pattern metabolites (PAMPs) and initiates an innate immune response, a critical step for pathogen elimination and engagement of adaptive immunity (By similarity). Specifically recognizes and binds ADP-D-glycero-beta-D-manno-heptose (ADP-Heptose), a potent PAMP present in all Gram-negative and some Gram-positive bacteria. ADP-Heptose-binding stimulates its kinase activity to phosphorylate and activate TIFA, triggering proinflammatory NF-kappa-B signaling (By similarity). May be i [...] | Uncharacterized protein FAM241A. | 0.547 |
| Alpk1 | Tifa | ENSMUSP00000029662 | ENSMUSP00000127700 | Alpha-protein kinase 1; Serine/threonine-protein kinase that detects bacterial pathogen-associated molecular pattern metabolites (PAMPs) and initiates an innate immune response, a critical step for pathogen elimination and engagement of adaptive immunity (By similarity). Specifically recognizes and binds ADP-D-glycero-beta-D-manno-heptose (ADP-Heptose), a potent PAMP present in all Gram-negative and some Gram-positive bacteria. ADP-Heptose-binding stimulates its kinase activity to phosphorylate and activate TIFA, triggering proinflammatory NF-kappa-B signaling (By similarity). May be i [...] | TRAF-interacting protein with FHA domain-containing protein A; Adapter molecule that plays a key role in the activation of proinflammatory NF-kappa-B signaling following detection of bacterial pathogen-associated molecular pattern metabolites (PAMPs). Promotes activation of an innate immune response by inducing the oligomerization and polyubiquitination of TRAF6, which leads to the activation of TAK1 and IKK through a proteasome- independent mechanism (By similarity). TIFA-dependent innate immune response is triggered by ADP-D-glycero-beta-D-manno-heptose (ADP- Heptose), a potent PAMP [...] | 0.953 |
| Alpk1 | Zgrf1 | ENSMUSP00000029662 | ENSMUSP00000044432 | Alpha-protein kinase 1; Serine/threonine-protein kinase that detects bacterial pathogen-associated molecular pattern metabolites (PAMPs) and initiates an innate immune response, a critical step for pathogen elimination and engagement of adaptive immunity (By similarity). Specifically recognizes and binds ADP-D-glycero-beta-D-manno-heptose (ADP-Heptose), a potent PAMP present in all Gram-negative and some Gram-positive bacteria. ADP-Heptose-binding stimulates its kinase activity to phosphorylate and activate TIFA, triggering proinflammatory NF-kappa-B signaling (By similarity). May be i [...] | Protein ZGRF1. | 0.415 |
| Ap1ar | Alpk1 | ENSMUSP00000059669 | ENSMUSP00000029662 | Adaptor-related protein complex 1-associated regulatory protein. | Alpha-protein kinase 1; Serine/threonine-protein kinase that detects bacterial pathogen-associated molecular pattern metabolites (PAMPs) and initiates an innate immune response, a critical step for pathogen elimination and engagement of adaptive immunity (By similarity). Specifically recognizes and binds ADP-D-glycero-beta-D-manno-heptose (ADP-Heptose), a potent PAMP present in all Gram-negative and some Gram-positive bacteria. ADP-Heptose-binding stimulates its kinase activity to phosphorylate and activate TIFA, triggering proinflammatory NF-kappa-B signaling (By similarity). May be i [...] | 0.434 |
| Ap1ar | Fam241a | ENSMUSP00000059669 | ENSMUSP00000142535 | Adaptor-related protein complex 1-associated regulatory protein. | Uncharacterized protein FAM241A. | 0.609 |
| Fam241a | Alpk1 | ENSMUSP00000142535 | ENSMUSP00000029662 | Uncharacterized protein FAM241A. | Alpha-protein kinase 1; Serine/threonine-protein kinase that detects bacterial pathogen-associated molecular pattern metabolites (PAMPs) and initiates an innate immune response, a critical step for pathogen elimination and engagement of adaptive immunity (By similarity). Specifically recognizes and binds ADP-D-glycero-beta-D-manno-heptose (ADP-Heptose), a potent PAMP present in all Gram-negative and some Gram-positive bacteria. ADP-Heptose-binding stimulates its kinase activity to phosphorylate and activate TIFA, triggering proinflammatory NF-kappa-B signaling (By similarity). May be i [...] | 0.547 |
| Fam241a | Ap1ar | ENSMUSP00000142535 | ENSMUSP00000059669 | Uncharacterized protein FAM241A. | Adaptor-related protein complex 1-associated regulatory protein. | 0.609 |
| Fam241a | Reep5 | ENSMUSP00000142535 | ENSMUSP00000006027 | Uncharacterized protein FAM241A. | Receptor expression-enhancing protein 5; May promote functional cell surface expression of olfactory receptors; Belongs to the DP1 family. | 0.722 |
| Fam241a | Rpn2 | ENSMUSP00000142535 | ENSMUSP00000112081 | Uncharacterized protein FAM241A. | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...] | 0.514 |
| Fam241a | Rtn4 | ENSMUSP00000142535 | ENSMUSP00000099907 | Uncharacterized protein FAM241A. | Reticulon-4; Required to induce the formation and stabilization of endoplasmic reticulum (ER) tubules. They regulate membrane morphogenesis in the ER by promoting tubular ER production. They influence nuclear envelope expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins. However each isoform have specific functions mainly depending on their tissue expression specificities. [Isoform B]: Mainly function in endothelial cells and vascular smooth muscle cells, is also involved in immune system regulation (Probable). Modulator of vascular remod [...] | 0.749 |
| Fam241a | Sema3a | ENSMUSP00000142535 | ENSMUSP00000030714 | Uncharacterized protein FAM241A. | Semaphorin-3A; Plays a role in growth cones guidance. May function to pattern sensory projections by selectively repelling axons that normally terminate dorsally. Involved in the development of the olfactory system and in neuronal control of puberty (By similarity). Belongs to the semaphorin family. | 0.554 |
| Fam241a | Sgcd | ENSMUSP00000142535 | ENSMUSP00000076459 | Uncharacterized protein FAM241A. | Delta-sarcoglycan; Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. | 0.501 |
| Fam241a | Sgcz | ENSMUSP00000142535 | ENSMUSP00000113912 | Uncharacterized protein FAM241A. | Zeta-sarcoglycan; Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. May play a role in the maintenance of striated muscle membrane stability. | 0.732 |
| Fam241a | Tifa | ENSMUSP00000142535 | ENSMUSP00000127700 | Uncharacterized protein FAM241A. | TRAF-interacting protein with FHA domain-containing protein A; Adapter molecule that plays a key role in the activation of proinflammatory NF-kappa-B signaling following detection of bacterial pathogen-associated molecular pattern metabolites (PAMPs). Promotes activation of an innate immune response by inducing the oligomerization and polyubiquitination of TRAF6, which leads to the activation of TAK1 and IKK through a proteasome- independent mechanism (By similarity). TIFA-dependent innate immune response is triggered by ADP-D-glycero-beta-D-manno-heptose (ADP- Heptose), a potent PAMP [...] | 0.598 |
| Fam241a | Zgrf1 | ENSMUSP00000142535 | ENSMUSP00000044432 | Uncharacterized protein FAM241A. | Protein ZGRF1. | 0.480 |
| Reep5 | Fam241a | ENSMUSP00000006027 | ENSMUSP00000142535 | Receptor expression-enhancing protein 5; May promote functional cell surface expression of olfactory receptors; Belongs to the DP1 family. | Uncharacterized protein FAM241A. | 0.722 |
| Reep5 | Rtn4 | ENSMUSP00000006027 | ENSMUSP00000099907 | Receptor expression-enhancing protein 5; May promote functional cell surface expression of olfactory receptors; Belongs to the DP1 family. | Reticulon-4; Required to induce the formation and stabilization of endoplasmic reticulum (ER) tubules. They regulate membrane morphogenesis in the ER by promoting tubular ER production. They influence nuclear envelope expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins. However each isoform have specific functions mainly depending on their tissue expression specificities. [Isoform B]: Mainly function in endothelial cells and vascular smooth muscle cells, is also involved in immune system regulation (Probable). Modulator of vascular remod [...] | 0.852 |
| Rpn2 | Fam241a | ENSMUSP00000112081 | ENSMUSP00000142535 | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...] | Uncharacterized protein FAM241A. | 0.514 |
| Rtn4 | Fam241a | ENSMUSP00000099907 | ENSMUSP00000142535 | Reticulon-4; Required to induce the formation and stabilization of endoplasmic reticulum (ER) tubules. They regulate membrane morphogenesis in the ER by promoting tubular ER production. They influence nuclear envelope expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins. However each isoform have specific functions mainly depending on their tissue expression specificities. [Isoform B]: Mainly function in endothelial cells and vascular smooth muscle cells, is also involved in immune system regulation (Probable). Modulator of vascular remod [...] | Uncharacterized protein FAM241A. | 0.749 |
