STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Akr1clAldo-keto reductase family 1, member C-like. (322 aa)    
Predicted Functional Partners:
Eva1b
Protein eva-1 homolog B.
      
 0.608
Themis3
Protein THEMIS3.
      
 0.520
Zfp473
Zinc finger protein 473 homolog; Involved in histone 3'-end pre-mRNA processing by associating with U7 snRNP and interacting with SLBP/pre-mRNA complex. Increases histone 3'-end pre-mRNA processing but has no effect on U7 snRNP levels, when overexpressed. Required for cell cycle progression from G1 to S phases (By similarity); Belongs to the krueppel C2H2-type zinc-finger protein family.
   
 
 0.449
Slc15a5
Solute carrier family 15 member 5; Proton oligopeptide cotransporter.
      
 0.449
Akr1b10
Aldo-keto reductase family 1, member B10 (aldose reductase).
  
0.448
Hsd3b1
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1; A bifunctional enzyme responsible for the oxidation and isomerization of 3beta-hydroxy-Delta(5)-steroid precursors to 3-oxo- Delta(4)-steroids, an essential step in steroid hormone biosynthesis. Specifically catalyzes the conversion of pregnenolone to progesterone, 17alpha-hydroxypregnenolone to 17alpha-hydroxyprogesterone, dehydroepiandrosterone (DHEA) to 4-androstenedione, and androstenediol to testosterone. Additionally, catalyzes the interconversion between 3beta-hydroxy and 3-oxo-5alpha-androstane steroids controlli [...]
   
  
 0.446
Malrd1
MAM and LDL-receptor class A domain-containing protein 1; Enhances production and/or transport of FGF15 and thus has a role in regulation of bile acid synthesis.
      
 0.436
Rbp2
Retinol-binding protein 2; Intracellular transport of retinol; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
   
  0.418
Akr1c18
Aldo-keto reductase family 1 member C18; Catalyzes the conversion of progesterone into 20-alpha- dihydroprogesterone (20 alpha-OHP); Belongs to the aldo/keto reductase family.
  
 
 
0.416
Akr1c20
Aldo-keto reductase family 1, member C20.
  
  
0.411
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.