STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Rnf180E3 ubiquitin-protein ligase RNF180; E3 ubiquitin-protein ligase which promotes polyubiquitination and degradation by the proteasome pathway of ZIC2. (575 aa)    
Predicted Functional Partners:
Nt5el
5' nucleotidase, ecto-like; Belongs to the 5'-nucleotidase family.
   
  
 0.644
Srek1ip1
Protein SREK1IP1; Possible splicing regulator involved in the control of cellular survival.
      
 0.633
Ppwd1
Peptidylprolyl isomerase domain and WD repeat-containing protein 1; PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. May be involved in pre-mRNA splicing.
      
 0.542
Rnf38
E3 ubiquitin-protein ligase RNF38; Acts as an E3 ubiquitin-protein ligase able to ubiquitinate p53/TP53 which promotes its relocalization to discrete foci associated with PML nuclear bodies. Exhibits preference for UBE2D2 as a E2 enzyme.
   
  
 0.523
Shisal2b
Protein shisa-like-2B.
      
 0.485
Rnf103
E3 ubiquitin-protein ligase RNF103; Acts as an E2-dependent E3 ubiquitin-protein ligase, probably involved in the ER-associated protein degradation pathway.
      
 0.483
Pnma2
Paraneoplastic antigen Ma2 homolog; Belongs to the PNMA family.
      
 0.444
Pcdhb10
Protocadherin beta 10.
      
 0.442
Krtap8-1
Keratin-associated protein 8-1; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
   
  
 0.440
Pcdhb4
Protocadherin beta 4.
      
 0.426
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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