node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Col3a1 | Efemp2 | ENSMUSP00000085192 | ENSMUSP00000064719 | Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12. | EGF-containing fibulin-like extracellular matrix protein 2; Belongs to the fibulin family. | 0.710 |
Col3a1 | Eln | ENSMUSP00000085192 | ENSMUSP00000015138 | Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12. | Elastin; Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. Molecular determinant of the late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle. | 0.805 |
Col3a1 | Fbn1 | ENSMUSP00000085192 | ENSMUSP00000099524 | Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12. | Fibrillin-1; [Fibrillin-1]: Structural component of the 10-12 nm diameter microfibrils of the extracellular matrix, which conveys both structural and regulatory properties to load-bearing connective tissues. Fibrillin-1-containing microfibrils provide long-term force bearing structural support. In tissues such as the lung, blood vessels and skin, microfibrils form the periphery of the elastic fiber, acting as a scaffold for the deposition of elastin. In addition, microfibrils can occur as elastin-independent networks in tissues such as the ciliary zonule, tendon, cornea and glomerulus [...] | 0.956 |
Col3a1 | Fkbp10 | ENSMUSP00000085192 | ENSMUSP00000001595 | Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12. | Peptidyl-prolyl cis-trans isomerase FKBP10; PPIases accelerate the folding of proteins during protein synthesis. | 0.447 |
Col3a1 | Lox | ENSMUSP00000085192 | ENSMUSP00000025409 | Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12. | Protein-lysine 6-oxidase, short form; Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture. | 0.839 |
Col3a1 | Loxl1 | ENSMUSP00000085192 | ENSMUSP00000057406 | Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12. | Lysyl oxidase homolog 1; Active on elastin and collagen substrates. | 0.689 |
Col3a1 | Ltbp1 | ENSMUSP00000085192 | ENSMUSP00000001927 | Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12. | Latent-transforming growth factor beta-binding protein 1; Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta. | 0.463 |
Col3a1 | Mfap4 | ENSMUSP00000085192 | ENSMUSP00000038971 | Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12. | Microfibril-associated glycoprotein 4; Could be involved in calcium-dependent cell adhesion or intercellular interactions. May contribute to the elastic fiber assembly and/or maintenance. | 0.442 |
Col3a1 | Mfap5 | ENSMUSP00000085192 | ENSMUSP00000122863 | Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12. | Microfibrillar-associated protein 5; May play a role in hematopoiesis. In the cardiovascular system, could regulate growth factors or participate in cell signaling in maintaining large vessel integrity. Component of the elastin-associated microfibrils (By similarity). | 0.626 |
Efemp2 | Col3a1 | ENSMUSP00000064719 | ENSMUSP00000085192 | EGF-containing fibulin-like extracellular matrix protein 2; Belongs to the fibulin family. | Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12. | 0.710 |
Efemp2 | Eln | ENSMUSP00000064719 | ENSMUSP00000015138 | EGF-containing fibulin-like extracellular matrix protein 2; Belongs to the fibulin family. | Elastin; Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. Molecular determinant of the late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle. | 0.917 |
Efemp2 | Fbn1 | ENSMUSP00000064719 | ENSMUSP00000099524 | EGF-containing fibulin-like extracellular matrix protein 2; Belongs to the fibulin family. | Fibrillin-1; [Fibrillin-1]: Structural component of the 10-12 nm diameter microfibrils of the extracellular matrix, which conveys both structural and regulatory properties to load-bearing connective tissues. Fibrillin-1-containing microfibrils provide long-term force bearing structural support. In tissues such as the lung, blood vessels and skin, microfibrils form the periphery of the elastic fiber, acting as a scaffold for the deposition of elastin. In addition, microfibrils can occur as elastin-independent networks in tissues such as the ciliary zonule, tendon, cornea and glomerulus [...] | 0.836 |
Efemp2 | Fkbp10 | ENSMUSP00000064719 | ENSMUSP00000001595 | EGF-containing fibulin-like extracellular matrix protein 2; Belongs to the fibulin family. | Peptidyl-prolyl cis-trans isomerase FKBP10; PPIases accelerate the folding of proteins during protein synthesis. | 0.767 |
Efemp2 | Lox | ENSMUSP00000064719 | ENSMUSP00000025409 | EGF-containing fibulin-like extracellular matrix protein 2; Belongs to the fibulin family. | Protein-lysine 6-oxidase, short form; Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture. | 0.802 |
Efemp2 | Loxl1 | ENSMUSP00000064719 | ENSMUSP00000057406 | EGF-containing fibulin-like extracellular matrix protein 2; Belongs to the fibulin family. | Lysyl oxidase homolog 1; Active on elastin and collagen substrates. | 0.793 |
Efemp2 | Ltbp1 | ENSMUSP00000064719 | ENSMUSP00000001927 | EGF-containing fibulin-like extracellular matrix protein 2; Belongs to the fibulin family. | Latent-transforming growth factor beta-binding protein 1; Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta. | 0.742 |
Efemp2 | Mfap2 | ENSMUSP00000064719 | ENSMUSP00000071868 | EGF-containing fibulin-like extracellular matrix protein 2; Belongs to the fibulin family. | Microfibrillar-associated protein 2; Component of the elastin-associated microfibrils. | 0.834 |
Efemp2 | Mfap4 | ENSMUSP00000064719 | ENSMUSP00000038971 | EGF-containing fibulin-like extracellular matrix protein 2; Belongs to the fibulin family. | Microfibril-associated glycoprotein 4; Could be involved in calcium-dependent cell adhesion or intercellular interactions. May contribute to the elastic fiber assembly and/or maintenance. | 0.659 |
Efemp2 | Mfap5 | ENSMUSP00000064719 | ENSMUSP00000122863 | EGF-containing fibulin-like extracellular matrix protein 2; Belongs to the fibulin family. | Microfibrillar-associated protein 5; May play a role in hematopoiesis. In the cardiovascular system, could regulate growth factors or participate in cell signaling in maintaining large vessel integrity. Component of the elastin-associated microfibrils (By similarity). | 0.784 |
Eln | Col3a1 | ENSMUSP00000015138 | ENSMUSP00000085192 | Elastin; Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. Molecular determinant of the late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle. | Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12. | 0.805 |