node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cir1 | Nkapl | ENSMUSP00000049834 | ENSMUSP00000065168 | Corepressor interacting with RBPJ 1; Regulates transcription and acts as corepressor for RBPJ. Recruits RBPJ to the Sin3-histone deacetylase complex (HDAC). Required for RBPJ-mediated repression of transcription (By similarity). May modulate splice site selection during alternative splicing of pre- mRNAs. | NKAP-like protein; Transcriptional repressor of Notch-mediated signaling. Required for spermatogenesis; Belongs to the NKAP family. | 0.596 |
Dhx8 | Fam32a | ENSMUSP00000037251 | ENSMUSP00000003123 | ATP-dependent RNA helicase DHX8; Involved in pre-mRNA splicing as component of the spliceosome. Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome. | Protein FAM32A; May induce G2 arrest and apoptosis (By similarity). May also increase cell sensitivity to apoptotic stimuli (By similarity). In cell lines, may play a role in the inhibition of anchor-independent cell growth. | 0.557 |
Dhx8 | Nkapl | ENSMUSP00000037251 | ENSMUSP00000065168 | ATP-dependent RNA helicase DHX8; Involved in pre-mRNA splicing as component of the spliceosome. Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome. | NKAP-like protein; Transcriptional repressor of Notch-mediated signaling. Required for spermatogenesis; Belongs to the NKAP family. | 0.571 |
Dhx8 | Prpf19 | ENSMUSP00000037251 | ENSMUSP00000136858 | ATP-dependent RNA helicase DHX8; Involved in pre-mRNA splicing as component of the spliceosome. Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome. | Pre-mRNA-processing factor 19; [Isoform 1]: Ubiquitin-protein ligase which is a core component of several complexes mainly involved in pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome. Core component of the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity. During assembly of the spliceosome, mediates 'Lys-63'-linked polyubiquitination of the U4 spliceosomal protein PRPF3. Ubiquitination of PRPF3 allows its recognition by the U5 comp [...] | 0.934 |
Dhx8 | Sde2 | ENSMUSP00000037251 | ENSMUSP00000037890 | ATP-dependent RNA helicase DHX8; Involved in pre-mRNA splicing as component of the spliceosome. Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome. | Replication stress response regulator SDE2; Involved in both DNA replication and cell cycle control. Unprocessed SDE2 interacts with PCNA via its PIP-box. The interaction with PCNA prevents monoubiquitination of the latter thereby inhibiting translesion DNA synthesis. The binding of SDE2 to PCNA also leads to processing of SDE2 by an unidentified deubiquitinating enzyme, cleaving off the N-terminal ubiquitin-like domain. The resulting mature SDE2 is degraded by the DCX(DTL) complex in a cell cycle- and DNA damage dependent manner. Binding of SDE2 to PCNA is necessary to counteract dama [...] | 0.581 |
Fam32a | Dhx8 | ENSMUSP00000003123 | ENSMUSP00000037251 | Protein FAM32A; May induce G2 arrest and apoptosis (By similarity). May also increase cell sensitivity to apoptotic stimuli (By similarity). In cell lines, may play a role in the inhibition of anchor-independent cell growth. | ATP-dependent RNA helicase DHX8; Involved in pre-mRNA splicing as component of the spliceosome. Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome. | 0.557 |
Fam32a | Nkapl | ENSMUSP00000003123 | ENSMUSP00000065168 | Protein FAM32A; May induce G2 arrest and apoptosis (By similarity). May also increase cell sensitivity to apoptotic stimuli (By similarity). In cell lines, may play a role in the inhibition of anchor-independent cell growth. | NKAP-like protein; Transcriptional repressor of Notch-mediated signaling. Required for spermatogenesis; Belongs to the NKAP family. | 0.486 |
Fam32a | Prpf19 | ENSMUSP00000003123 | ENSMUSP00000136858 | Protein FAM32A; May induce G2 arrest and apoptosis (By similarity). May also increase cell sensitivity to apoptotic stimuli (By similarity). In cell lines, may play a role in the inhibition of anchor-independent cell growth. | Pre-mRNA-processing factor 19; [Isoform 1]: Ubiquitin-protein ligase which is a core component of several complexes mainly involved in pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome. Core component of the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity. During assembly of the spliceosome, mediates 'Lys-63'-linked polyubiquitination of the U4 spliceosomal protein PRPF3. Ubiquitination of PRPF3 allows its recognition by the U5 comp [...] | 0.537 |
Fam32a | Sde2 | ENSMUSP00000003123 | ENSMUSP00000037890 | Protein FAM32A; May induce G2 arrest and apoptosis (By similarity). May also increase cell sensitivity to apoptotic stimuli (By similarity). In cell lines, may play a role in the inhibition of anchor-independent cell growth. | Replication stress response regulator SDE2; Involved in both DNA replication and cell cycle control. Unprocessed SDE2 interacts with PCNA via its PIP-box. The interaction with PCNA prevents monoubiquitination of the latter thereby inhibiting translesion DNA synthesis. The binding of SDE2 to PCNA also leads to processing of SDE2 by an unidentified deubiquitinating enzyme, cleaving off the N-terminal ubiquitin-like domain. The resulting mature SDE2 is degraded by the DCX(DTL) complex in a cell cycle- and DNA damage dependent manner. Binding of SDE2 to PCNA is necessary to counteract dama [...] | 0.870 |
Nkapl | Cir1 | ENSMUSP00000065168 | ENSMUSP00000049834 | NKAP-like protein; Transcriptional repressor of Notch-mediated signaling. Required for spermatogenesis; Belongs to the NKAP family. | Corepressor interacting with RBPJ 1; Regulates transcription and acts as corepressor for RBPJ. Recruits RBPJ to the Sin3-histone deacetylase complex (HDAC). Required for RBPJ-mediated repression of transcription (By similarity). May modulate splice site selection during alternative splicing of pre- mRNAs. | 0.596 |
Nkapl | Dhx8 | ENSMUSP00000065168 | ENSMUSP00000037251 | NKAP-like protein; Transcriptional repressor of Notch-mediated signaling. Required for spermatogenesis; Belongs to the NKAP family. | ATP-dependent RNA helicase DHX8; Involved in pre-mRNA splicing as component of the spliceosome. Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome. | 0.571 |
Nkapl | Fam32a | ENSMUSP00000065168 | ENSMUSP00000003123 | NKAP-like protein; Transcriptional repressor of Notch-mediated signaling. Required for spermatogenesis; Belongs to the NKAP family. | Protein FAM32A; May induce G2 arrest and apoptosis (By similarity). May also increase cell sensitivity to apoptotic stimuli (By similarity). In cell lines, may play a role in the inhibition of anchor-independent cell growth. | 0.486 |
Nkapl | Nos1ap | ENSMUSP00000065168 | ENSMUSP00000125251 | NKAP-like protein; Transcriptional repressor of Notch-mediated signaling. Required for spermatogenesis; Belongs to the NKAP family. | Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein; Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with nNOS/NOS1. The complex formed with NOS1 and synapsins is necessary for specific NO and synapsin functions at a presynaptic level. Mediates an indirect interaction between NOS1 and RASD1 leading to enhance the ability of NOS1 to activate RASD1. Competes with DLG4 for interaction with NOS1, possibly affecting NOS1 activity by regulating the interaction between NOS1 and DLG4 (By similarity). | 0.557 |
Nkapl | Pgbd1 | ENSMUSP00000065168 | ENSMUSP00000097307 | NKAP-like protein; Transcriptional repressor of Notch-mediated signaling. Required for spermatogenesis; Belongs to the NKAP family. | PiggyBac transposable element-derived 1. | 0.562 |
Nkapl | Prpf19 | ENSMUSP00000065168 | ENSMUSP00000136858 | NKAP-like protein; Transcriptional repressor of Notch-mediated signaling. Required for spermatogenesis; Belongs to the NKAP family. | Pre-mRNA-processing factor 19; [Isoform 1]: Ubiquitin-protein ligase which is a core component of several complexes mainly involved in pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome. Core component of the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity. During assembly of the spliceosome, mediates 'Lys-63'-linked polyubiquitination of the U4 spliceosomal protein PRPF3. Ubiquitination of PRPF3 allows its recognition by the U5 comp [...] | 0.575 |
Nkapl | Prpf38a | ENSMUSP00000065168 | ENSMUSP00000078207 | NKAP-like protein; Transcriptional repressor of Notch-mediated signaling. Required for spermatogenesis; Belongs to the NKAP family. | Pre-mRNA-splicing factor 38A; Involved in pre-mRNA splicing as a component of the spliceosome; Belongs to the PRP38 family. | 0.576 |
Nkapl | Sde2 | ENSMUSP00000065168 | ENSMUSP00000037890 | NKAP-like protein; Transcriptional repressor of Notch-mediated signaling. Required for spermatogenesis; Belongs to the NKAP family. | Replication stress response regulator SDE2; Involved in both DNA replication and cell cycle control. Unprocessed SDE2 interacts with PCNA via its PIP-box. The interaction with PCNA prevents monoubiquitination of the latter thereby inhibiting translesion DNA synthesis. The binding of SDE2 to PCNA also leads to processing of SDE2 by an unidentified deubiquitinating enzyme, cleaving off the N-terminal ubiquitin-like domain. The resulting mature SDE2 is degraded by the DCX(DTL) complex in a cell cycle- and DNA damage dependent manner. Binding of SDE2 to PCNA is necessary to counteract dama [...] | 0.494 |
Nkapl | Zkscan4 | ENSMUSP00000065168 | ENSMUSP00000054604 | NKAP-like protein; Transcriptional repressor of Notch-mediated signaling. Required for spermatogenesis; Belongs to the NKAP family. | Zinc finger with KRAB and SCAN domains 4. | 0.685 |
Nkapl | Zscan26 | ENSMUSP00000065168 | ENSMUSP00000106111 | NKAP-like protein; Transcriptional repressor of Notch-mediated signaling. Required for spermatogenesis; Belongs to the NKAP family. | Zinc finger and SCAN domain-containing protein 26; May be involved in transcriptional regulation. | 0.576 |
Nos1ap | Nkapl | ENSMUSP00000125251 | ENSMUSP00000065168 | Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein; Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with nNOS/NOS1. The complex formed with NOS1 and synapsins is necessary for specific NO and synapsin functions at a presynaptic level. Mediates an indirect interaction between NOS1 and RASD1 leading to enhance the ability of NOS1 to activate RASD1. Competes with DLG4 for interaction with NOS1, possibly affecting NOS1 activity by regulating the interaction between NOS1 and DLG4 (By similarity). | NKAP-like protein; Transcriptional repressor of Notch-mediated signaling. Required for spermatogenesis; Belongs to the NKAP family. | 0.557 |