node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Casp4 | Gsdmc4 | ENSMUSP00000027012 | ENSMUSP00000140269 | Caspase-4 subunit p10; Proinflammatory caspase. Essential effector of NLRP3 inflammasome-dependent CASP1 activation and IL1B and IL18 secretion in response to non- canonical activators, such as UVB radiation, cholera enterotoxin subunit B and cytosolic LPS, as well as infection with Gram-negative bacteria. Independently of NLRP3 inflammasome and CASP1, promotes pyroptosis, through GSDMD cleavage and activation, and IL1A, IL18 and HMGB1 release in response to non-canonical inflammasome activators. Plays a crucial role in the restriction of Salmonella typhimurium replication in colonic e [...] | Gasdermin-C4; The N-terminal moiety promotes pyroptosis and exhibits bactericidal activity. The physiological relevance of these observations is unknown; Belongs to the gasdermin family. | 0.478 |
Casp4 | Gsdme | ENSMUSP00000027012 | ENSMUSP00000031845 | Caspase-4 subunit p10; Proinflammatory caspase. Essential effector of NLRP3 inflammasome-dependent CASP1 activation and IL1B and IL18 secretion in response to non- canonical activators, such as UVB radiation, cholera enterotoxin subunit B and cytosolic LPS, as well as infection with Gram-negative bacteria. Independently of NLRP3 inflammasome and CASP1, promotes pyroptosis, through GSDMD cleavage and activation, and IL1A, IL18 and HMGB1 release in response to non-canonical inflammasome activators. Plays a crucial role in the restriction of Salmonella typhimurium replication in colonic e [...] | Gasdermin-E, C-terminal; Plays a role in the TP53-regulated cellular response to DNA damage probably by cooperating with TP53. | 0.763 |
Casp4 | Pjvk | ENSMUSP00000027012 | ENSMUSP00000097566 | Caspase-4 subunit p10; Proinflammatory caspase. Essential effector of NLRP3 inflammasome-dependent CASP1 activation and IL1B and IL18 secretion in response to non- canonical activators, such as UVB radiation, cholera enterotoxin subunit B and cytosolic LPS, as well as infection with Gram-negative bacteria. Independently of NLRP3 inflammasome and CASP1, promotes pyroptosis, through GSDMD cleavage and activation, and IL1A, IL18 and HMGB1 release in response to non-canonical inflammasome activators. Plays a crucial role in the restriction of Salmonella typhimurium replication in colonic e [...] | Pejvakin; Essential in the activity of auditory pathway neurons; Belongs to the gasdermin family. | 0.617 |
Clmn | Gsdmc4 | ENSMUSP00000105563 | ENSMUSP00000140269 | Calmin. | Gasdermin-C4; The N-terminal moiety promotes pyroptosis and exhibits bactericidal activity. The physiological relevance of these observations is unknown; Belongs to the gasdermin family. | 0.401 |
Gsdmc4 | Casp4 | ENSMUSP00000140269 | ENSMUSP00000027012 | Gasdermin-C4; The N-terminal moiety promotes pyroptosis and exhibits bactericidal activity. The physiological relevance of these observations is unknown; Belongs to the gasdermin family. | Caspase-4 subunit p10; Proinflammatory caspase. Essential effector of NLRP3 inflammasome-dependent CASP1 activation and IL1B and IL18 secretion in response to non- canonical activators, such as UVB radiation, cholera enterotoxin subunit B and cytosolic LPS, as well as infection with Gram-negative bacteria. Independently of NLRP3 inflammasome and CASP1, promotes pyroptosis, through GSDMD cleavage and activation, and IL1A, IL18 and HMGB1 release in response to non-canonical inflammasome activators. Plays a crucial role in the restriction of Salmonella typhimurium replication in colonic e [...] | 0.478 |
Gsdmc4 | Clmn | ENSMUSP00000140269 | ENSMUSP00000105563 | Gasdermin-C4; The N-terminal moiety promotes pyroptosis and exhibits bactericidal activity. The physiological relevance of these observations is unknown; Belongs to the gasdermin family. | Calmin. | 0.401 |
Gsdmc4 | Gsdme | ENSMUSP00000140269 | ENSMUSP00000031845 | Gasdermin-C4; The N-terminal moiety promotes pyroptosis and exhibits bactericidal activity. The physiological relevance of these observations is unknown; Belongs to the gasdermin family. | Gasdermin-E, C-terminal; Plays a role in the TP53-regulated cellular response to DNA damage probably by cooperating with TP53. | 0.833 |
Gsdmc4 | Pjvk | ENSMUSP00000140269 | ENSMUSP00000097566 | Gasdermin-C4; The N-terminal moiety promotes pyroptosis and exhibits bactericidal activity. The physiological relevance of these observations is unknown; Belongs to the gasdermin family. | Pejvakin; Essential in the activity of auditory pathway neurons; Belongs to the gasdermin family. | 0.734 |
Gsdme | Casp4 | ENSMUSP00000031845 | ENSMUSP00000027012 | Gasdermin-E, C-terminal; Plays a role in the TP53-regulated cellular response to DNA damage probably by cooperating with TP53. | Caspase-4 subunit p10; Proinflammatory caspase. Essential effector of NLRP3 inflammasome-dependent CASP1 activation and IL1B and IL18 secretion in response to non- canonical activators, such as UVB radiation, cholera enterotoxin subunit B and cytosolic LPS, as well as infection with Gram-negative bacteria. Independently of NLRP3 inflammasome and CASP1, promotes pyroptosis, through GSDMD cleavage and activation, and IL1A, IL18 and HMGB1 release in response to non-canonical inflammasome activators. Plays a crucial role in the restriction of Salmonella typhimurium replication in colonic e [...] | 0.763 |
Gsdme | Gsdmc4 | ENSMUSP00000031845 | ENSMUSP00000140269 | Gasdermin-E, C-terminal; Plays a role in the TP53-regulated cellular response to DNA damage probably by cooperating with TP53. | Gasdermin-C4; The N-terminal moiety promotes pyroptosis and exhibits bactericidal activity. The physiological relevance of these observations is unknown; Belongs to the gasdermin family. | 0.833 |
Pjvk | Casp4 | ENSMUSP00000097566 | ENSMUSP00000027012 | Pejvakin; Essential in the activity of auditory pathway neurons; Belongs to the gasdermin family. | Caspase-4 subunit p10; Proinflammatory caspase. Essential effector of NLRP3 inflammasome-dependent CASP1 activation and IL1B and IL18 secretion in response to non- canonical activators, such as UVB radiation, cholera enterotoxin subunit B and cytosolic LPS, as well as infection with Gram-negative bacteria. Independently of NLRP3 inflammasome and CASP1, promotes pyroptosis, through GSDMD cleavage and activation, and IL1A, IL18 and HMGB1 release in response to non-canonical inflammasome activators. Plays a crucial role in the restriction of Salmonella typhimurium replication in colonic e [...] | 0.617 |
Pjvk | Gsdmc4 | ENSMUSP00000097566 | ENSMUSP00000140269 | Pejvakin; Essential in the activity of auditory pathway neurons; Belongs to the gasdermin family. | Gasdermin-C4; The N-terminal moiety promotes pyroptosis and exhibits bactericidal activity. The physiological relevance of these observations is unknown; Belongs to the gasdermin family. | 0.734 |