node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cdsn | Dsg1a | ENSMUSP00000048596 | ENSMUSP00000076393 | Corneodesmosin; Important for the epidermal barrier integrity. | Desmoglein-1-alpha; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. | 0.986 |
Cdsn | Dsg1b | ENSMUSP00000048596 | ENSMUSP00000076026 | Corneodesmosin; Important for the epidermal barrier integrity. | Desmoglein-1-beta; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. | 0.986 |
Cdsn | Flg | ENSMUSP00000048596 | ENSMUSP00000142003 | Corneodesmosin; Important for the epidermal barrier integrity. | Filaggrin. | 0.743 |
Cdsn | Klk5 | ENSMUSP00000048596 | ENSMUSP00000049339 | Corneodesmosin; Important for the epidermal barrier integrity. | Kallikrein-related-peptidase 5; Belongs to the peptidase S1 family. | 0.628 |
Cdsn | Klk7 | ENSMUSP00000048596 | ENSMUSP00000032955 | Corneodesmosin; Important for the epidermal barrier integrity. | Kallikrein-7; May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. Cleaves insulin A chain at '14-Tyr-|-Gln-15' and insulin B chain at '6-Leu-|-Cys-7', '16-Tyr-|-Leu-17', '25-Phe-|-Tyr-26' and '26-Tyr-|-Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines. | 0.749 |
Cdsn | Lor | ENSMUSP00000048596 | ENSMUSP00000052128 | Corneodesmosin; Important for the epidermal barrier integrity. | Loricrin; Major keratinocyte cell envelope protein. | 0.774 |
Cdsn | Spink5 | ENSMUSP00000048596 | ENSMUSP00000066214 | Corneodesmosin; Important for the epidermal barrier integrity. | Serine peptidase inhibitor, Kazal type 5. | 0.662 |
Cela2a | Klk5 | ENSMUSP00000099539 | ENSMUSP00000049339 | Chymotrypsin-like elastase family member 2A; Acts upon elastin; Belongs to the peptidase S1 family. Elastase subfamily. | Kallikrein-related-peptidase 5; Belongs to the peptidase S1 family. | 0.812 |
Cela2a | Spink5 | ENSMUSP00000099539 | ENSMUSP00000066214 | Chymotrypsin-like elastase family member 2A; Acts upon elastin; Belongs to the peptidase S1 family. Elastase subfamily. | Serine peptidase inhibitor, Kazal type 5. | 0.581 |
Crnn | Flg | ENSMUSP00000141980 | ENSMUSP00000142003 | Cornulin. | Filaggrin. | 0.439 |
Crnn | Lor | ENSMUSP00000141980 | ENSMUSP00000052128 | Cornulin. | Loricrin; Major keratinocyte cell envelope protein. | 0.539 |
Crnn | Spink5 | ENSMUSP00000141980 | ENSMUSP00000066214 | Cornulin. | Serine peptidase inhibitor, Kazal type 5. | 0.625 |
Dsg1a | Cdsn | ENSMUSP00000076393 | ENSMUSP00000048596 | Desmoglein-1-alpha; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. | Corneodesmosin; Important for the epidermal barrier integrity. | 0.986 |
Dsg1a | Dsg1b | ENSMUSP00000076393 | ENSMUSP00000076026 | Desmoglein-1-alpha; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. | Desmoglein-1-beta; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. | 0.955 |
Dsg1a | Flg | ENSMUSP00000076393 | ENSMUSP00000142003 | Desmoglein-1-alpha; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. | Filaggrin. | 0.798 |
Dsg1a | Klk5 | ENSMUSP00000076393 | ENSMUSP00000049339 | Desmoglein-1-alpha; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. | Kallikrein-related-peptidase 5; Belongs to the peptidase S1 family. | 0.665 |
Dsg1a | Klk7 | ENSMUSP00000076393 | ENSMUSP00000032955 | Desmoglein-1-alpha; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. | Kallikrein-7; May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. Cleaves insulin A chain at '14-Tyr-|-Gln-15' and insulin B chain at '6-Leu-|-Cys-7', '16-Tyr-|-Leu-17', '25-Phe-|-Tyr-26' and '26-Tyr-|-Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines. | 0.737 |
Dsg1a | Lor | ENSMUSP00000076393 | ENSMUSP00000052128 | Desmoglein-1-alpha; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. | Loricrin; Major keratinocyte cell envelope protein. | 0.703 |
Dsg1a | Spink5 | ENSMUSP00000076393 | ENSMUSP00000066214 | Desmoglein-1-alpha; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. | Serine peptidase inhibitor, Kazal type 5. | 0.757 |
Dsg1b | Cdsn | ENSMUSP00000076026 | ENSMUSP00000048596 | Desmoglein-1-beta; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. | Corneodesmosin; Important for the epidermal barrier integrity. | 0.986 |