node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Aatf | Bms1 | ENSMUSP00000018841 | ENSMUSP00000032237 | Protein AATF; May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression (By similarity). Belongs to the AATF family. | BMS1 homolog, ribosome assembly protein (Yeast). | 0.996 |
Aatf | Bysl | ENSMUSP00000018841 | ENSMUSP00000024783 | Protein AATF; May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression (By similarity). Belongs to the AATF family. | Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits; Belongs to the bystin family. | 0.996 |
Aatf | Gcc1 | ENSMUSP00000018841 | ENSMUSP00000087997 | Protein AATF; May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression (By similarity). Belongs to the AATF family. | GRIP and coiled-coil domain-containing protein 1; Probably involved in maintaining Golgi structure. | 0.905 |
Aatf | Heatr1 | ENSMUSP00000018841 | ENSMUSP00000054084 | Protein AATF; May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression (By similarity). Belongs to the AATF family. | HEAT repeat-containing 1. | 0.990 |
Aatf | Imp4 | ENSMUSP00000018841 | ENSMUSP00000027303 | Protein AATF; May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression (By similarity). Belongs to the AATF family. | U3 small nucleolar ribonucleoprotein protein IMP4; Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing (By similarity). | 0.993 |
Aatf | Nob1 | ENSMUSP00000018841 | ENSMUSP00000003946 | Protein AATF; May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression (By similarity). Belongs to the AATF family. | RNA-binding protein NOB1; May play a role in mRNA degradation (By similarity). Endonuclease required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits (By similarity). | 0.650 |
Aatf | Pwp2 | ENSMUSP00000018841 | ENSMUSP00000045812 | Protein AATF; May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression (By similarity). Belongs to the AATF family. | Periodic tryptophan protein 2 homolog. | 0.994 |
Aatf | Riok2 | ENSMUSP00000018841 | ENSMUSP00000024620 | Protein AATF; May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression (By similarity). Belongs to the AATF family. | Serine/threonine-protein kinase RIO2; Serine/threonine-protein kinase involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre-ribosome particles (pre-40S) from the nucleus to the cytoplasm. Its kinase activity is required for the release of NOB1, PNO1 and LTV1 from the late pre-40S and the processing of 18S-E pre- rRNA to the mature 18S rRNA. May regulate the timing of the metaphase- anaphase transition during mitotic progression, and its phosphorylation, may regulate this function. | 0.621 |
Aatf | Tsr1 | ENSMUSP00000018841 | ENSMUSP00000039027 | Protein AATF; May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression (By similarity). Belongs to the AATF family. | Pre-rRNA-processing protein TSR1 homolog; Required during maturation of the 40S ribosomal subunit in the nucleolus. | 0.828 |
Bms1 | Aatf | ENSMUSP00000032237 | ENSMUSP00000018841 | BMS1 homolog, ribosome assembly protein (Yeast). | Protein AATF; May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression (By similarity). Belongs to the AATF family. | 0.996 |
Bms1 | Bysl | ENSMUSP00000032237 | ENSMUSP00000024783 | BMS1 homolog, ribosome assembly protein (Yeast). | Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits; Belongs to the bystin family. | 0.999 |
Bms1 | Fau | ENSMUSP00000032237 | ENSMUSP00000136358 | BMS1 homolog, ribosome assembly protein (Yeast). | Ubiquitin-like protein FUBI; Belongs to the ubiquitin family. | 0.878 |
Bms1 | Gcc1 | ENSMUSP00000032237 | ENSMUSP00000087997 | BMS1 homolog, ribosome assembly protein (Yeast). | GRIP and coiled-coil domain-containing protein 1; Probably involved in maintaining Golgi structure. | 0.863 |
Bms1 | Heatr1 | ENSMUSP00000032237 | ENSMUSP00000054084 | BMS1 homolog, ribosome assembly protein (Yeast). | HEAT repeat-containing 1. | 0.999 |
Bms1 | Imp4 | ENSMUSP00000032237 | ENSMUSP00000027303 | BMS1 homolog, ribosome assembly protein (Yeast). | U3 small nucleolar ribonucleoprotein protein IMP4; Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing (By similarity). | 0.997 |
Bms1 | Nob1 | ENSMUSP00000032237 | ENSMUSP00000003946 | BMS1 homolog, ribosome assembly protein (Yeast). | RNA-binding protein NOB1; May play a role in mRNA degradation (By similarity). Endonuclease required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits (By similarity). | 0.911 |
Bms1 | Pwp2 | ENSMUSP00000032237 | ENSMUSP00000045812 | BMS1 homolog, ribosome assembly protein (Yeast). | Periodic tryptophan protein 2 homolog. | 0.999 |
Bms1 | Riok2 | ENSMUSP00000032237 | ENSMUSP00000024620 | BMS1 homolog, ribosome assembly protein (Yeast). | Serine/threonine-protein kinase RIO2; Serine/threonine-protein kinase involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre-ribosome particles (pre-40S) from the nucleus to the cytoplasm. Its kinase activity is required for the release of NOB1, PNO1 and LTV1 from the late pre-40S and the processing of 18S-E pre- rRNA to the mature 18S rRNA. May regulate the timing of the metaphase- anaphase transition during mitotic progression, and its phosphorylation, may regulate this function. | 0.806 |
Bms1 | Tsr1 | ENSMUSP00000032237 | ENSMUSP00000039027 | BMS1 homolog, ribosome assembly protein (Yeast). | Pre-rRNA-processing protein TSR1 homolog; Required during maturation of the 40S ribosomal subunit in the nucleolus. | 0.955 |
Bysl | Aatf | ENSMUSP00000024783 | ENSMUSP00000018841 | Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits; Belongs to the bystin family. | Protein AATF; May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression (By similarity). Belongs to the AATF family. | 0.996 |