node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C6 | C7 | ENSMUSP00000124417 | ENSMUSP00000106317 | Complement component 6. | Complement component 7. | 0.980 |
C6 | C8a | ENSMUSP00000124417 | ENSMUSP00000067541 | Complement component 6. | Complement component C8 alpha chain; Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C8A inserts into the target membrane, but does not form pores by itself (By similarity). | 0.934 |
C6 | C8b | ENSMUSP00000124417 | ENSMUSP00000031663 | Complement component 6. | Complement component C8 beta chain; Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells; Belongs to the complement C6/C7/C8/C9 family. | 0.964 |
C6 | C8g | ENSMUSP00000124417 | ENSMUSP00000041855 | Complement component 6. | Complement component C8 gamma chain; C8 is a constituent of the membrane attack complex. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind retinol (By similarity). | 0.960 |
C6 | C9 | ENSMUSP00000124417 | ENSMUSP00000022749 | Complement component 6. | Complement component C9; Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C9 is the pore-forming subunit of the MAC; Belongs to the complement C6/C7/C8/C9 family. | 0.983 |
C6 | Hc | ENSMUSP00000124417 | ENSMUSP00000028233 | Complement component 6. | Complement C5 alpha' chain; Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled. | 0.993 |
C6 | Slc25a5 | ENSMUSP00000124417 | ENSMUSP00000016463 | Complement component 6. | ADP/ATP translocase 2, N-terminally processed; Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation (By similarity). | 0.731 |
C7 | C6 | ENSMUSP00000106317 | ENSMUSP00000124417 | Complement component 7. | Complement component 6. | 0.980 |
C7 | C8a | ENSMUSP00000106317 | ENSMUSP00000067541 | Complement component 7. | Complement component C8 alpha chain; Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C8A inserts into the target membrane, but does not form pores by itself (By similarity). | 0.922 |
C7 | C8b | ENSMUSP00000106317 | ENSMUSP00000031663 | Complement component 7. | Complement component C8 beta chain; Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells; Belongs to the complement C6/C7/C8/C9 family. | 0.975 |
C7 | C8g | ENSMUSP00000106317 | ENSMUSP00000041855 | Complement component 7. | Complement component C8 gamma chain; C8 is a constituent of the membrane attack complex. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind retinol (By similarity). | 0.922 |
C7 | C9 | ENSMUSP00000106317 | ENSMUSP00000022749 | Complement component 7. | Complement component C9; Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C9 is the pore-forming subunit of the MAC; Belongs to the complement C6/C7/C8/C9 family. | 0.965 |
C7 | Hc | ENSMUSP00000106317 | ENSMUSP00000028233 | Complement component 7. | Complement C5 alpha' chain; Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled. | 0.990 |
C7 | Slc25a5 | ENSMUSP00000106317 | ENSMUSP00000016463 | Complement component 7. | ADP/ATP translocase 2, N-terminally processed; Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation (By similarity). | 0.731 |
C8a | C6 | ENSMUSP00000067541 | ENSMUSP00000124417 | Complement component C8 alpha chain; Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C8A inserts into the target membrane, but does not form pores by itself (By similarity). | Complement component 6. | 0.934 |
C8a | C7 | ENSMUSP00000067541 | ENSMUSP00000106317 | Complement component C8 alpha chain; Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C8A inserts into the target membrane, but does not form pores by itself (By similarity). | Complement component 7. | 0.922 |
C8a | C8b | ENSMUSP00000067541 | ENSMUSP00000031663 | Complement component C8 alpha chain; Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C8A inserts into the target membrane, but does not form pores by itself (By similarity). | Complement component C8 beta chain; Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells; Belongs to the complement C6/C7/C8/C9 family. | 0.981 |
C8a | C8g | ENSMUSP00000067541 | ENSMUSP00000041855 | Complement component C8 alpha chain; Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C8A inserts into the target membrane, but does not form pores by itself (By similarity). | Complement component C8 gamma chain; C8 is a constituent of the membrane attack complex. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind retinol (By similarity). | 0.992 |
C8a | C9 | ENSMUSP00000067541 | ENSMUSP00000022749 | Complement component C8 alpha chain; Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C8A inserts into the target membrane, but does not form pores by itself (By similarity). | Complement component C9; Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C9 is the pore-forming subunit of the MAC; Belongs to the complement C6/C7/C8/C9 family. | 0.982 |
C8a | F13b | ENSMUSP00000067541 | ENSMUSP00000027615 | Complement component C8 alpha chain; Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C8A inserts into the target membrane, but does not form pores by itself (By similarity). | Coagulation factor XIII B chain; The B chain of factor XIII is not catalytically active, but is thought to stabilize the A subunits and regulate the rate of transglutaminase formation by thrombin. | 0.759 |