STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Slc25a40Solute carrier family 25 member 40; Belongs to the mitochondrial carrier (TC 2.A.29) family. (337 aa)    
Predicted Functional Partners:
Rundc3b
RUN domain-containing protein 3B.
   
  
 0.701
Tmem243
Transmembrane protein 243, mitochondrial.
   
  
 0.658
Wdr44
WD repeat-containing protein 44; Downstream effector for RAB11. May be involved in vesicle recycling (By similarity).
   
  
 0.646
Rrbp1
Ribosome-binding protein 1; Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane.
   
  
 0.524
Crot
Peroxisomal carnitine O-octanoyltransferase; Beta-oxidation of fatty acids. The highest activity concerns the C6 to C10 chain length substrate.
   
  
 0.506
Dmtf1
Cyclin-D-binding Myb-like transcription factor 1; Transcriptional activator which activates the CDKN2A/ARF locus in response to Ras-Raf signaling, thereby promoting p53/TP53- dependent growth arrest. May also cooperate with MYB to activate transcription of the ANPEP gene. Binds to the consensus sequence 5'- CCCG[GT]ATGT-3'. Belongs to the DMTF1 family.
   
  
 0.505
Slc6a6
Sodium- and chloride-dependent taurine transporter; Sodium-dependent taurine and beta-alanine transporter. Chloride ions are necessary for optimal uptake.
   
  
 0.504
Lars
Leucine--tRNA ligase, cytoplasmic; Catalyzes the specific attachment of an amino acid to its cognate tRNA in a two step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Exhibits a post-transfer editing activity to hydrolyze mischarged tRNAs; Belongs to the class-I aminoacyl-tRNA synthetase family.
 
 
    0.485
Gm648
Gene model 648, (NCBI).
      
 0.483
Txnl1
Thioredoxin-like protein 1; Active thioredoxin with a redox potential of about -250 mV.
   
    0.476
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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