node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Dmtn | Epb42 | ENSMUSP00000106612 | ENSMUSP00000099548 | Dematin; Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Plays also a role as a modulator [...] | Erythrocyte membrane protein band 4.2; Probably plays an important role in the regulation of erythrocyte shape and mechanical properties; Belongs to the transglutaminase superfamily. Transglutaminase family. | 0.742 |
Dmtn | Osbp2 | ENSMUSP00000106612 | ENSMUSP00000068652 | Dematin; Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Plays also a role as a modulator [...] | Oxysterol-binding protein 2; Binds 7-ketocholesterol; Belongs to the OSBP family. | 0.545 |
Eif4enif1 | Osbp2 | ENSMUSP00000136768 | ENSMUSP00000068652 | Eukaryotic translation initiation factor 4E transporter; Nucleoplasmic shuttling protein, which inhibits translation initiation. Mediates the nuclear import of EIF4E by a piggy-back mechanism. | Oxysterol-binding protein 2; Binds 7-ketocholesterol; Belongs to the OSBP family. | 0.515 |
Epb42 | Dmtn | ENSMUSP00000099548 | ENSMUSP00000106612 | Erythrocyte membrane protein band 4.2; Probably plays an important role in the regulation of erythrocyte shape and mechanical properties; Belongs to the transglutaminase superfamily. Transglutaminase family. | Dematin; Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Plays also a role as a modulator [...] | 0.742 |
Epb42 | Osbp2 | ENSMUSP00000099548 | ENSMUSP00000068652 | Erythrocyte membrane protein band 4.2; Probably plays an important role in the regulation of erythrocyte shape and mechanical properties; Belongs to the transglutaminase superfamily. Transglutaminase family. | Oxysterol-binding protein 2; Binds 7-ketocholesterol; Belongs to the OSBP family. | 0.440 |
Lzts1 | Osbp2 | ENSMUSP00000139117 | ENSMUSP00000068652 | Leucine zipper putative tumor suppressor 1; Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as tumor suppressor (By similarity). Belongs to the LZTS family. | Oxysterol-binding protein 2; Binds 7-ketocholesterol; Belongs to the OSBP family. | 0.498 |
Mospd1 | Osbp2 | ENSMUSP00000023836 | ENSMUSP00000068652 | Motile sperm domain-containing protein 1; Plays a role in differentiation and/or proliferation of mesenchymal stem cells. Proposed to be involved in epithelial-to-mesenchymal transition (EMT). However, another study suggests that it is not required for EMT or stem cell self-renewal and acts during later stages of differentiation. | Oxysterol-binding protein 2; Binds 7-ketocholesterol; Belongs to the OSBP family. | 0.438 |
Mospd1 | Vapa | ENSMUSP00000023836 | ENSMUSP00000024897 | Motile sperm domain-containing protein 1; Plays a role in differentiation and/or proliferation of mesenchymal stem cells. Proposed to be involved in epithelial-to-mesenchymal transition (EMT). However, another study suggests that it is not required for EMT or stem cell self-renewal and acts during later stages of differentiation. | Vesicle-associated membrane protein-associated protein A; Binds to OSBPL3, which mediates recruitment of VAPA to plasma membrane sites. The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface. With OSBPL3, may regulate ER morphology. May play a role in vesicle trafficking; Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family. | 0.526 |
Mospd1 | Vapb | ENSMUSP00000023836 | ENSMUSP00000064699 | Motile sperm domain-containing protein 1; Plays a role in differentiation and/or proliferation of mesenchymal stem cells. Proposed to be involved in epithelial-to-mesenchymal transition (EMT). However, another study suggests that it is not required for EMT or stem cell self-renewal and acts during later stages of differentiation. | Vesicle-associated membrane protein-associated protein B; Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation. | 0.405 |
Mospd3 | Osbp2 | ENSMUSP00000040828 | ENSMUSP00000068652 | Motile sperm domain-containing protein 3. | Oxysterol-binding protein 2; Binds 7-ketocholesterol; Belongs to the OSBP family. | 0.438 |
Mospd3 | Vapa | ENSMUSP00000040828 | ENSMUSP00000024897 | Motile sperm domain-containing protein 3. | Vesicle-associated membrane protein-associated protein A; Binds to OSBPL3, which mediates recruitment of VAPA to plasma membrane sites. The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface. With OSBPL3, may regulate ER morphology. May play a role in vesicle trafficking; Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family. | 0.489 |
Osbp2 | Dmtn | ENSMUSP00000068652 | ENSMUSP00000106612 | Oxysterol-binding protein 2; Binds 7-ketocholesterol; Belongs to the OSBP family. | Dematin; Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Plays also a role as a modulator [...] | 0.545 |
Osbp2 | Eif4enif1 | ENSMUSP00000068652 | ENSMUSP00000136768 | Oxysterol-binding protein 2; Binds 7-ketocholesterol; Belongs to the OSBP family. | Eukaryotic translation initiation factor 4E transporter; Nucleoplasmic shuttling protein, which inhibits translation initiation. Mediates the nuclear import of EIF4E by a piggy-back mechanism. | 0.515 |
Osbp2 | Epb42 | ENSMUSP00000068652 | ENSMUSP00000099548 | Oxysterol-binding protein 2; Binds 7-ketocholesterol; Belongs to the OSBP family. | Erythrocyte membrane protein band 4.2; Probably plays an important role in the regulation of erythrocyte shape and mechanical properties; Belongs to the transglutaminase superfamily. Transglutaminase family. | 0.440 |
Osbp2 | Lzts1 | ENSMUSP00000068652 | ENSMUSP00000139117 | Oxysterol-binding protein 2; Binds 7-ketocholesterol; Belongs to the OSBP family. | Leucine zipper putative tumor suppressor 1; Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as tumor suppressor (By similarity). Belongs to the LZTS family. | 0.498 |
Osbp2 | Mospd1 | ENSMUSP00000068652 | ENSMUSP00000023836 | Oxysterol-binding protein 2; Binds 7-ketocholesterol; Belongs to the OSBP family. | Motile sperm domain-containing protein 1; Plays a role in differentiation and/or proliferation of mesenchymal stem cells. Proposed to be involved in epithelial-to-mesenchymal transition (EMT). However, another study suggests that it is not required for EMT or stem cell self-renewal and acts during later stages of differentiation. | 0.438 |
Osbp2 | Mospd3 | ENSMUSP00000068652 | ENSMUSP00000040828 | Oxysterol-binding protein 2; Binds 7-ketocholesterol; Belongs to the OSBP family. | Motile sperm domain-containing protein 3. | 0.438 |
Osbp2 | Plek2 | ENSMUSP00000068652 | ENSMUSP00000021544 | Oxysterol-binding protein 2; Binds 7-ketocholesterol; Belongs to the OSBP family. | Pleckstrin-2; May help orchestrate cytoskeletal arrangement. Contribute to lamellipodia formation. Overexpression of pleckstrin 2 causes large lamellipodia and peripheral ruffle formation. | 0.457 |
Osbp2 | Sacm1l | ENSMUSP00000068652 | ENSMUSP00000026270 | Oxysterol-binding protein 2; Binds 7-ketocholesterol; Belongs to the OSBP family. | Phosphatidylinositide phosphatase SAC1; Phosphoinositide phosphatase that hydrolyzes phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 4-phosphate (PtdIns(4)P) (By similarity). Has low activity towards PtdIns(3,5)P2 (By similarity). | 0.428 |
Osbp2 | Vapa | ENSMUSP00000068652 | ENSMUSP00000024897 | Oxysterol-binding protein 2; Binds 7-ketocholesterol; Belongs to the OSBP family. | Vesicle-associated membrane protein-associated protein A; Binds to OSBPL3, which mediates recruitment of VAPA to plasma membrane sites. The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface. With OSBPL3, may regulate ER morphology. May play a role in vesicle trafficking; Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family. | 0.794 |