node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cyp2c23 | Cyp2c29 | ENSMUSP00000026211 | ENSMUSP00000003137 | Cytochrome P450 2C44; A cytochrome P450 monooxygenase involved in polyunsaturated fatty acids (PUFAs) metabolism and signaling. Catalyzes preferentially the epoxidation of double bonds of PUFAs. Converts arachidonoic acid primarily to stereospecific products (8R,9S)-epoxyeicosatrienoate (EET) and (11R,12S)-EET. Via EETs may inhibit the epithelial sodium channels in nephron segments, leading to increased sodium excretion and stable systemic blood pressure. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, wi [...] | Cytochrome P450 2C29; Metabolizes arachidonic acid to produce 14,15-cis- epoxyeicosatrienoic acid (EET). | 0.740 |
Cyp2c23 | Cyp2c37 | ENSMUSP00000026211 | ENSMUSP00000045362 | Cytochrome P450 2C44; A cytochrome P450 monooxygenase involved in polyunsaturated fatty acids (PUFAs) metabolism and signaling. Catalyzes preferentially the epoxidation of double bonds of PUFAs. Converts arachidonoic acid primarily to stereospecific products (8R,9S)-epoxyeicosatrienoate (EET) and (11R,12S)-EET. Via EETs may inhibit the epithelial sodium channels in nephron segments, leading to increased sodium excretion and stable systemic blood pressure. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, wi [...] | Cytochrome P450 2C37; Metabolizes arachidonic acid to produce 12- hydroxyeicosatetraenoic acid (HETE); Belongs to the cytochrome P450 family. | 0.707 |
Cyp2c23 | Cyp2c38 | ENSMUSP00000026211 | ENSMUSP00000044722 | Cytochrome P450 2C44; A cytochrome P450 monooxygenase involved in polyunsaturated fatty acids (PUFAs) metabolism and signaling. Catalyzes preferentially the epoxidation of double bonds of PUFAs. Converts arachidonoic acid primarily to stereospecific products (8R,9S)-epoxyeicosatrienoate (EET) and (11R,12S)-EET. Via EETs may inhibit the epithelial sodium channels in nephron segments, leading to increased sodium excretion and stable systemic blood pressure. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, wi [...] | Cytochrome P450 2C38; Metabolizes arachidonic acid to produce 11,12- epoxyeicosatrienoic acid (EET); Belongs to the cytochrome P450 family. | 0.696 |
Cyp2c23 | Cyp2c40 | ENSMUSP00000026211 | ENSMUSP00000158887 | Cytochrome P450 2C44; A cytochrome P450 monooxygenase involved in polyunsaturated fatty acids (PUFAs) metabolism and signaling. Catalyzes preferentially the epoxidation of double bonds of PUFAs. Converts arachidonoic acid primarily to stereospecific products (8R,9S)-epoxyeicosatrienoate (EET) and (11R,12S)-EET. Via EETs may inhibit the epithelial sodium channels in nephron segments, leading to increased sodium excretion and stable systemic blood pressure. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, wi [...] | Cytochrome P450 2C40; A cytochrome P450 monooxygenase that may play a major role in the metabolism of arachidonic acid in the intestinal tract. Exhibits regioselective hydroxylase and epoxidase activity toward arachidonic acid, producing 16(R)- hydroxyeicosatetraenoic acid (HETE) and (14R,15S)-epoxyeicosatrienoic acid (EpETrE) as major products. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). | 0.699 |
Cyp2c23 | Cyp2c50 | ENSMUSP00000026211 | ENSMUSP00000079065 | Cytochrome P450 2C44; A cytochrome P450 monooxygenase involved in polyunsaturated fatty acids (PUFAs) metabolism and signaling. Catalyzes preferentially the epoxidation of double bonds of PUFAs. Converts arachidonoic acid primarily to stereospecific products (8R,9S)-epoxyeicosatrienoate (EET) and (11R,12S)-EET. Via EETs may inhibit the epithelial sodium channels in nephron segments, leading to increased sodium excretion and stable systemic blood pressure. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, wi [...] | Cytochrome P450 2C50; Metabolizes arachidonic acid to several midchain and omega- terminal hydroxyeicosatetraenoic acids (HETE). | 0.702 |
Cyp2c23 | Cyp2c70 | ENSMUSP00000026211 | ENSMUSP00000060584 | Cytochrome P450 2C44; A cytochrome P450 monooxygenase involved in polyunsaturated fatty acids (PUFAs) metabolism and signaling. Catalyzes preferentially the epoxidation of double bonds of PUFAs. Converts arachidonoic acid primarily to stereospecific products (8R,9S)-epoxyeicosatrienoate (EET) and (11R,12S)-EET. Via EETs may inhibit the epithelial sodium channels in nephron segments, leading to increased sodium excretion and stable systemic blood pressure. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, wi [...] | Cytochrome P450 2C70; A cytochrome P450 monooxygenase involved in muricholic acid (MCA) synthesis. Hydroxylates at the 6-beta position two major bile acids, chenodeoxycholic acid (CDCA) and ursodeoxycholic acid (UDCA) to form alpha-MCA and beta-MCA, respectively. May regulate NR1H4/farnesoid X receptor signaling, as taurine-conjugated MCAs are antagonists of NR1H4. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotei [...] | 0.718 |
Cyp2c23 | Cyp2j5 | ENSMUSP00000026211 | ENSMUSP00000030299 | Cytochrome P450 2C44; A cytochrome P450 monooxygenase involved in polyunsaturated fatty acids (PUFAs) metabolism and signaling. Catalyzes preferentially the epoxidation of double bonds of PUFAs. Converts arachidonoic acid primarily to stereospecific products (8R,9S)-epoxyeicosatrienoate (EET) and (11R,12S)-EET. Via EETs may inhibit the epithelial sodium channels in nephron segments, leading to increased sodium excretion and stable systemic blood pressure. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, wi [...] | Cytochrome P450 2J5. | 0.720 |
Cyp2c23 | Cyp2j6 | ENSMUSP00000026211 | ENSMUSP00000030303 | Cytochrome P450 2C44; A cytochrome P450 monooxygenase involved in polyunsaturated fatty acids (PUFAs) metabolism and signaling. Catalyzes preferentially the epoxidation of double bonds of PUFAs. Converts arachidonoic acid primarily to stereospecific products (8R,9S)-epoxyeicosatrienoate (EET) and (11R,12S)-EET. Via EETs may inhibit the epithelial sodium channels in nephron segments, leading to increased sodium excretion and stable systemic blood pressure. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, wi [...] | Cytochrome P450 2J6. | 0.691 |
Cyp2c23 | Cyp2j9 | ENSMUSP00000026211 | ENSMUSP00000050464 | Cytochrome P450 2C44; A cytochrome P450 monooxygenase involved in polyunsaturated fatty acids (PUFAs) metabolism and signaling. Catalyzes preferentially the epoxidation of double bonds of PUFAs. Converts arachidonoic acid primarily to stereospecific products (8R,9S)-epoxyeicosatrienoate (EET) and (11R,12S)-EET. Via EETs may inhibit the epithelial sodium channels in nephron segments, leading to increased sodium excretion and stable systemic blood pressure. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, wi [...] | Cytochrome P450, family 2, subfamily j, polypeptide 9; Belongs to the cytochrome P450 family. | 0.685 |
Cyp2c23 | Ephx2 | ENSMUSP00000026211 | ENSMUSP00000069209 | Cytochrome P450 2C44; A cytochrome P450 monooxygenase involved in polyunsaturated fatty acids (PUFAs) metabolism and signaling. Catalyzes preferentially the epoxidation of double bonds of PUFAs. Converts arachidonoic acid primarily to stereospecific products (8R,9S)-epoxyeicosatrienoate (EET) and (11R,12S)-EET. Via EETs may inhibit the epithelial sodium channels in nephron segments, leading to increased sodium excretion and stable systemic blood pressure. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, wi [...] | Bifunctional epoxide hydrolase 2; Bifunctional enzyme. The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides. Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides. Also determines steady-state levels of physiological mediators. The N-terminal domain has lipid phosphatase activity, with the highest activity towards threo-9,10-phosphonooxy- hydroxy-octadecanoic acid, followed by erythro-9,10-phosphonooxy- hydroxy-octadecanoic acid, 12-phosphonooxy-octadec-9Z-enoic acid and 12-phosphonooxy-octadec-9E-e [...] | 0.910 |
Cyp2c29 | Cyp2c23 | ENSMUSP00000003137 | ENSMUSP00000026211 | Cytochrome P450 2C29; Metabolizes arachidonic acid to produce 14,15-cis- epoxyeicosatrienoic acid (EET). | Cytochrome P450 2C44; A cytochrome P450 monooxygenase involved in polyunsaturated fatty acids (PUFAs) metabolism and signaling. Catalyzes preferentially the epoxidation of double bonds of PUFAs. Converts arachidonoic acid primarily to stereospecific products (8R,9S)-epoxyeicosatrienoate (EET) and (11R,12S)-EET. Via EETs may inhibit the epithelial sodium channels in nephron segments, leading to increased sodium excretion and stable systemic blood pressure. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, wi [...] | 0.740 |
Cyp2c29 | Cyp2c37 | ENSMUSP00000003137 | ENSMUSP00000045362 | Cytochrome P450 2C29; Metabolizes arachidonic acid to produce 14,15-cis- epoxyeicosatrienoic acid (EET). | Cytochrome P450 2C37; Metabolizes arachidonic acid to produce 12- hydroxyeicosatetraenoic acid (HETE); Belongs to the cytochrome P450 family. | 0.773 |
Cyp2c29 | Cyp2c38 | ENSMUSP00000003137 | ENSMUSP00000044722 | Cytochrome P450 2C29; Metabolizes arachidonic acid to produce 14,15-cis- epoxyeicosatrienoic acid (EET). | Cytochrome P450 2C38; Metabolizes arachidonic acid to produce 11,12- epoxyeicosatrienoic acid (EET); Belongs to the cytochrome P450 family. | 0.866 |
Cyp2c29 | Cyp2c40 | ENSMUSP00000003137 | ENSMUSP00000158887 | Cytochrome P450 2C29; Metabolizes arachidonic acid to produce 14,15-cis- epoxyeicosatrienoic acid (EET). | Cytochrome P450 2C40; A cytochrome P450 monooxygenase that may play a major role in the metabolism of arachidonic acid in the intestinal tract. Exhibits regioselective hydroxylase and epoxidase activity toward arachidonic acid, producing 16(R)- hydroxyeicosatetraenoic acid (HETE) and (14R,15S)-epoxyeicosatrienoic acid (EpETrE) as major products. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). | 0.706 |
Cyp2c29 | Cyp2c50 | ENSMUSP00000003137 | ENSMUSP00000079065 | Cytochrome P450 2C29; Metabolizes arachidonic acid to produce 14,15-cis- epoxyeicosatrienoic acid (EET). | Cytochrome P450 2C50; Metabolizes arachidonic acid to several midchain and omega- terminal hydroxyeicosatetraenoic acids (HETE). | 0.846 |
Cyp2c29 | Cyp2c70 | ENSMUSP00000003137 | ENSMUSP00000060584 | Cytochrome P450 2C29; Metabolizes arachidonic acid to produce 14,15-cis- epoxyeicosatrienoic acid (EET). | Cytochrome P450 2C70; A cytochrome P450 monooxygenase involved in muricholic acid (MCA) synthesis. Hydroxylates at the 6-beta position two major bile acids, chenodeoxycholic acid (CDCA) and ursodeoxycholic acid (UDCA) to form alpha-MCA and beta-MCA, respectively. May regulate NR1H4/farnesoid X receptor signaling, as taurine-conjugated MCAs are antagonists of NR1H4. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotei [...] | 0.814 |
Cyp2c29 | Cyp2j5 | ENSMUSP00000003137 | ENSMUSP00000030299 | Cytochrome P450 2C29; Metabolizes arachidonic acid to produce 14,15-cis- epoxyeicosatrienoic acid (EET). | Cytochrome P450 2J5. | 0.812 |
Cyp2c29 | Cyp2j6 | ENSMUSP00000003137 | ENSMUSP00000030303 | Cytochrome P450 2C29; Metabolizes arachidonic acid to produce 14,15-cis- epoxyeicosatrienoic acid (EET). | Cytochrome P450 2J6. | 0.696 |
Cyp2c29 | Cyp2j9 | ENSMUSP00000003137 | ENSMUSP00000050464 | Cytochrome P450 2C29; Metabolizes arachidonic acid to produce 14,15-cis- epoxyeicosatrienoic acid (EET). | Cytochrome P450, family 2, subfamily j, polypeptide 9; Belongs to the cytochrome P450 family. | 0.686 |
Cyp2c29 | Ephx2 | ENSMUSP00000003137 | ENSMUSP00000069209 | Cytochrome P450 2C29; Metabolizes arachidonic acid to produce 14,15-cis- epoxyeicosatrienoic acid (EET). | Bifunctional epoxide hydrolase 2; Bifunctional enzyme. The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides. Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides. Also determines steady-state levels of physiological mediators. The N-terminal domain has lipid phosphatase activity, with the highest activity towards threo-9,10-phosphonooxy- hydroxy-octadecanoic acid, followed by erythro-9,10-phosphonooxy- hydroxy-octadecanoic acid, 12-phosphonooxy-octadec-9Z-enoic acid and 12-phosphonooxy-octadec-9E-e [...] | 0.919 |