node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Asgr1 | Asgr2 | ENSMUSP00000090637 | ENSMUSP00000099632 | Asialoglycoprotein receptor 1; Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N- acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface. | Asialoglycoprotein receptor 2; Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N- acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface. | 0.961 |
Asgr1 | Tg | ENSMUSP00000090637 | ENSMUSP00000070239 | Asialoglycoprotein receptor 1; Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N- acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface. | Thyroglobulin; Acts as a substrate for the production of iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3) (By similarity). The synthesis of T3 and T4 involves iodination of selected tyrosine residues of TG/thyroglobulin followed by their oxidative coupling (By similarity). Following TG re-internalization and lysosomal-mediated proteolysis, T3 and T4 are released from the polypeptide backbone leading to their secretion into the bloodstream (Probable). | 0.926 |
Asgr2 | Asgr1 | ENSMUSP00000099632 | ENSMUSP00000090637 | Asialoglycoprotein receptor 2; Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N- acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface. | Asialoglycoprotein receptor 1; Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N- acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface. | 0.961 |
Asgr2 | Tg | ENSMUSP00000099632 | ENSMUSP00000070239 | Asialoglycoprotein receptor 2; Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N- acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface. | Thyroglobulin; Acts as a substrate for the production of iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3) (By similarity). The synthesis of T3 and T4 involves iodination of selected tyrosine residues of TG/thyroglobulin followed by their oxidative coupling (By similarity). Following TG re-internalization and lysosomal-mediated proteolysis, T3 and T4 are released from the polypeptide backbone leading to their secretion into the bloodstream (Probable). | 0.901 |
Lrp2 | Tg | ENSMUSP00000079752 | ENSMUSP00000070239 | Low-density lipoprotein receptor-related protein 2; Multiligand endocytic receptor. Acts together with CUBN to mediate endocytosis of high-density lipoproteins. Mediates receptor-mediated uptake of polybasic drugs such as aprotinin, aminoglycosides and polymyxin B (By similarity). In the kidney, mediates the tubular uptake and clearance of leptin. Also mediates transport of leptin across the blood-brain barrier through endocytosis at the choroid plexus epithelium (By similarity). Endocytosis of leptin in neuronal cells is required for hypothalamic leptin signaling and leptin-mediated r [...] | Thyroglobulin; Acts as a substrate for the production of iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3) (By similarity). The synthesis of T3 and T4 involves iodination of selected tyrosine residues of TG/thyroglobulin followed by their oxidative coupling (By similarity). Following TG re-internalization and lysosomal-mediated proteolysis, T3 and T4 are released from the polypeptide backbone leading to their secretion into the bloodstream (Probable). | 0.957 |
Mb | Serpinb1b | ENSMUSP00000125995 | ENSMUSP00000016951 | Myoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. | Leukocyte elastase inhibitor B; Regulates the activity of the neutrophil proteases. Forms only a stable complex with CTSG/Cathepsin G. During inflammation, limits the activity of inflammatory caspases CASP1 and CASP4 by suppressing their caspase-recruitment domain (CARD) oligomerization and enzymatic activation. Belongs to the serpin family. Ov-serpin subfamily. | 0.795 |
Mb | Serpinb6b | ENSMUSP00000125995 | ENSMUSP00000105922 | Myoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. | Serine (Or cysteine) peptidase inhibitor, clade B, member 6B; Belongs to the serpin family. | 0.796 |
Mb | Serpinb9b | ENSMUSP00000125995 | ENSMUSP00000006392 | Myoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. | Serine (or cysteine) peptidase inhibitor, clade B, member 9b; Belongs to the serpin family. | 0.795 |
Mb | Serpinb9c | ENSMUSP00000125995 | ENSMUSP00000021837 | Myoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. | Serine (or cysteine) peptidase inhibitor, clade B, member 9c; Belongs to the serpin family. | 0.795 |
Mb | Serpinb9g | ENSMUSP00000125995 | ENSMUSP00000080597 | Myoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. | Serine (Or cysteine) peptidase inhibitor, clade B, member 9g; Belongs to the serpin family. | 0.795 |
Mb | Tg | ENSMUSP00000125995 | ENSMUSP00000070239 | Myoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. | Thyroglobulin; Acts as a substrate for the production of iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3) (By similarity). The synthesis of T3 and T4 involves iodination of selected tyrosine residues of TG/thyroglobulin followed by their oxidative coupling (By similarity). Following TG re-internalization and lysosomal-mediated proteolysis, T3 and T4 are released from the polypeptide backbone leading to their secretion into the bloodstream (Probable). | 0.910 |
Serpinb1b | Mb | ENSMUSP00000016951 | ENSMUSP00000125995 | Leukocyte elastase inhibitor B; Regulates the activity of the neutrophil proteases. Forms only a stable complex with CTSG/Cathepsin G. During inflammation, limits the activity of inflammatory caspases CASP1 and CASP4 by suppressing their caspase-recruitment domain (CARD) oligomerization and enzymatic activation. Belongs to the serpin family. Ov-serpin subfamily. | Myoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. | 0.795 |
Serpinb1b | Serpinb6b | ENSMUSP00000016951 | ENSMUSP00000105922 | Leukocyte elastase inhibitor B; Regulates the activity of the neutrophil proteases. Forms only a stable complex with CTSG/Cathepsin G. During inflammation, limits the activity of inflammatory caspases CASP1 and CASP4 by suppressing their caspase-recruitment domain (CARD) oligomerization and enzymatic activation. Belongs to the serpin family. Ov-serpin subfamily. | Serine (Or cysteine) peptidase inhibitor, clade B, member 6B; Belongs to the serpin family. | 0.694 |
Serpinb1b | Serpinb9b | ENSMUSP00000016951 | ENSMUSP00000006392 | Leukocyte elastase inhibitor B; Regulates the activity of the neutrophil proteases. Forms only a stable complex with CTSG/Cathepsin G. During inflammation, limits the activity of inflammatory caspases CASP1 and CASP4 by suppressing their caspase-recruitment domain (CARD) oligomerization and enzymatic activation. Belongs to the serpin family. Ov-serpin subfamily. | Serine (or cysteine) peptidase inhibitor, clade B, member 9b; Belongs to the serpin family. | 0.696 |
Serpinb1b | Serpinb9c | ENSMUSP00000016951 | ENSMUSP00000021837 | Leukocyte elastase inhibitor B; Regulates the activity of the neutrophil proteases. Forms only a stable complex with CTSG/Cathepsin G. During inflammation, limits the activity of inflammatory caspases CASP1 and CASP4 by suppressing their caspase-recruitment domain (CARD) oligomerization and enzymatic activation. Belongs to the serpin family. Ov-serpin subfamily. | Serine (or cysteine) peptidase inhibitor, clade B, member 9c; Belongs to the serpin family. | 0.688 |
Serpinb1b | Serpinb9g | ENSMUSP00000016951 | ENSMUSP00000080597 | Leukocyte elastase inhibitor B; Regulates the activity of the neutrophil proteases. Forms only a stable complex with CTSG/Cathepsin G. During inflammation, limits the activity of inflammatory caspases CASP1 and CASP4 by suppressing their caspase-recruitment domain (CARD) oligomerization and enzymatic activation. Belongs to the serpin family. Ov-serpin subfamily. | Serine (Or cysteine) peptidase inhibitor, clade B, member 9g; Belongs to the serpin family. | 0.693 |
Serpinb1b | Tg | ENSMUSP00000016951 | ENSMUSP00000070239 | Leukocyte elastase inhibitor B; Regulates the activity of the neutrophil proteases. Forms only a stable complex with CTSG/Cathepsin G. During inflammation, limits the activity of inflammatory caspases CASP1 and CASP4 by suppressing their caspase-recruitment domain (CARD) oligomerization and enzymatic activation. Belongs to the serpin family. Ov-serpin subfamily. | Thyroglobulin; Acts as a substrate for the production of iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3) (By similarity). The synthesis of T3 and T4 involves iodination of selected tyrosine residues of TG/thyroglobulin followed by their oxidative coupling (By similarity). Following TG re-internalization and lysosomal-mediated proteolysis, T3 and T4 are released from the polypeptide backbone leading to their secretion into the bloodstream (Probable). | 0.879 |
Serpinb6b | Mb | ENSMUSP00000105922 | ENSMUSP00000125995 | Serine (Or cysteine) peptidase inhibitor, clade B, member 6B; Belongs to the serpin family. | Myoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. | 0.796 |
Serpinb6b | Serpinb1b | ENSMUSP00000105922 | ENSMUSP00000016951 | Serine (Or cysteine) peptidase inhibitor, clade B, member 6B; Belongs to the serpin family. | Leukocyte elastase inhibitor B; Regulates the activity of the neutrophil proteases. Forms only a stable complex with CTSG/Cathepsin G. During inflammation, limits the activity of inflammatory caspases CASP1 and CASP4 by suppressing their caspase-recruitment domain (CARD) oligomerization and enzymatic activation. Belongs to the serpin family. Ov-serpin subfamily. | 0.694 |
Serpinb6b | Serpinb9b | ENSMUSP00000105922 | ENSMUSP00000006392 | Serine (Or cysteine) peptidase inhibitor, clade B, member 6B; Belongs to the serpin family. | Serine (or cysteine) peptidase inhibitor, clade B, member 9b; Belongs to the serpin family. | 0.699 |