Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Tmem143Transmembrane protein 143. (458 aa)    
Predicted Functional Partners:
Ccdc114
Coiled-coil domain-containing protein 114; Probable component of the outer dynein arm complex required along the entire axoneme for tethering of outer dynein arms. Belongs to the ODA1/DCC2 family.
   
  
 0.553
Tmem186
Transmembrane protein 186.
   
  
 0.545
Iqce
IQ domain-containing protein E; Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Required for proper limb morphogenesis (By similarity).
   
  
 0.528
Syngr4
Synaptogyrin-4.
   
  
 0.499
Phyhipl
Phytanoyl-CoA hydroxylase-interacting protein-like; May play a role in the development of the central system. Belongs to the PHYHIP family.
      
 0.496
Myl10
Myosin regulatory light chain 10.
      
 0.453
D16Ertd472e
Protein EURL homolog; Plays a role in cortical progenitor cell proliferation and differentiation. Promotes dendritic spine development of post-migratory cortical projection neurons by modulating the beta- catenin signaling pathway. Belongs to the EURL family.
      
 0.437
Mrpl47
39S ribosomal protein L47, mitochondrial; Belongs to the universal ribosomal protein uL29 family.
   
  
 0.414
Rmnd1
Required for meiotic nuclear division protein 1 homolog; Required for mitochondrial translation, possibly by coordinating the assembly or maintenance of the mitochondrial ribosome.
   
  
 0.409
Armc4
Armadillo repeat-containing protein 4; Ciliary protein that may be involved in a late step of axonemal outer dynein arm assembly.
      
 0.406
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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