STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Cbln3Cerebellin-3; May be involved in synaptic functions in the CNS. (197 aa)    
Predicted Functional Partners:
Gabra6
Gamma-aminobutyric acid receptor subunit alpha-6; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
   
  
 0.832
Grid2
Glutamate receptor ionotropic, delta-2; Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. Promotes synaptogenesis and mediates the D-Serine-dependent long term depression signals and AMPA receptor endocytosis of cerebellar parallel fiber- Purkinje cell (PF-PC) synapses through the beta-NRX1-CBLN1-GRID2 triad complex.
   
  
 0.751
Nynrin
Protein NYNRIN.
    
 
 0.730
Ccdc137
Coiled-coil domain-containing protein 137.
   
  
 0.705
Tmem69
Transmembrane protein 69.
      
 0.640
Stxbp6
Syntaxin-binding protein 6; Forms non-fusogenic complexes with SNAP25 and STX1A and may thereby modulate the formation of functional SNARE complexes and exocytosis.
      
 0.624
Fat2
Protocadherin Fat 2; Involved in the regulation of cell migration (By similarity). May be involved in mediating the organization of the parallel fibers of granule cells during cerebellar development (By similarity).
   
  
 0.586
Stoml1
Stomatin-like protein 1; May play a role in cholesterol transfer to late endosomes (By similarity). May play a role in modulating membrane acid-sensing ion channels. Can specifically inhibit proton-gated current of ASIC1 isoform 1. Can increase inactivation speed of ASIC3. May be involved in regulation of proton sensing in dorsal root ganglions ; Belongs to the band 7/mec-2 family.
   
 
 0.585
Cnpy1
Protein canopy homolog 1.
   
  
 0.582
Sdr39u1
Epimerase family protein SDR39U1; Putative NADP-dependent oxidoreductase.
      
 0.579
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
Server load: low (30%) [HD]