node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ankrd33 | Rtbdn | ENSMUSP00000067028 | ENSMUSP00000070558 | Photoreceptor ankyrin repeat protein; [Isoform 1]: Acts as a transcriptional repressor for CRX- activated photoreceptor gene regulation. | Retbindin; Riboflavin-binding protein which might have a role in retinal flavin transport; Belongs to the folate receptor family. | 0.480 |
Ankrd33 | Slc24a1 | ENSMUSP00000067028 | ENSMUSP00000035616 | Photoreceptor ankyrin repeat protein; [Isoform 1]: Acts as a transcriptional repressor for CRX- activated photoreceptor gene regulation. | Solute carrier family 24 (Sodium/potassium/calcium exchanger), member 1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. | 0.404 |
Best2 | Rtbdn | ENSMUSP00000147837 | ENSMUSP00000070558 | Bestrophin-2; Forms calcium-sensitive chloride channels. Permeable to bicarbonate. | Retbindin; Riboflavin-binding protein which might have a role in retinal flavin transport; Belongs to the folate receptor family. | 0.520 |
Flad1 | Rtbdn | ENSMUSP00000122252 | ENSMUSP00000070558 | Molybdenum cofactor biosynthesis protein-like region; Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme; In the C-terminal section; belongs to the PAPS reductase family. FAD1 subfamily. | Retbindin; Riboflavin-binding protein which might have a role in retinal flavin transport; Belongs to the folate receptor family. | 0.464 |
Guca2b | Rtbdn | ENSMUSP00000043203 | ENSMUSP00000070558 | Guanylate cyclase activator 2B; Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport (By similarity). | Retbindin; Riboflavin-binding protein which might have a role in retinal flavin transport; Belongs to the folate receptor family. | 0.516 |
Gucy1a2 | Rtbdn | ENSMUSP00000111398 | ENSMUSP00000070558 | Guanylate cyclase 1, soluble, alpha 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. | Retbindin; Riboflavin-binding protein which might have a role in retinal flavin transport; Belongs to the folate receptor family. | 0.545 |
Optc | Prph2 | ENSMUSP00000120568 | ENSMUSP00000024773 | Opticin; Inhibits angiogenesis in the vitreous humor of the eye, and therefore represses neovascularization. Binds collagen fibrils (By similarity). May be involved in collagen fiber organization via regulation of other members of the small leucine-rich repeat proteoglycan superfamily. | Peripherin-2; Essential for retina photoreceptor outer segment disk morphogenesis, may also play a role with ROM1 in the maintenance of outer segment disk structure. Required for the maintenance of retinal outer nuclear layer thickness. Required for the correct development and organization of the photoreceptor inner segment. Belongs to the PRPH2/ROM1 family. | 0.672 |
Optc | Rtbdn | ENSMUSP00000120568 | ENSMUSP00000070558 | Opticin; Inhibits angiogenesis in the vitreous humor of the eye, and therefore represses neovascularization. Binds collagen fibrils (By similarity). May be involved in collagen fiber organization via regulation of other members of the small leucine-rich repeat proteoglycan superfamily. | Retbindin; Riboflavin-binding protein which might have a role in retinal flavin transport; Belongs to the folate receptor family. | 0.544 |
Prph2 | Optc | ENSMUSP00000024773 | ENSMUSP00000120568 | Peripherin-2; Essential for retina photoreceptor outer segment disk morphogenesis, may also play a role with ROM1 in the maintenance of outer segment disk structure. Required for the maintenance of retinal outer nuclear layer thickness. Required for the correct development and organization of the photoreceptor inner segment. Belongs to the PRPH2/ROM1 family. | Opticin; Inhibits angiogenesis in the vitreous humor of the eye, and therefore represses neovascularization. Binds collagen fibrils (By similarity). May be involved in collagen fiber organization via regulation of other members of the small leucine-rich repeat proteoglycan superfamily. | 0.672 |
Prph2 | Rho | ENSMUSP00000024773 | ENSMUSP00000032471 | Peripherin-2; Essential for retina photoreceptor outer segment disk morphogenesis, may also play a role with ROM1 in the maintenance of outer segment disk structure. Required for the maintenance of retinal outer nuclear layer thickness. Required for the correct development and organization of the photoreceptor inner segment. Belongs to the PRPH2/ROM1 family. | Rhodopsin; Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling. | 0.869 |
Prph2 | Rtbdn | ENSMUSP00000024773 | ENSMUSP00000070558 | Peripherin-2; Essential for retina photoreceptor outer segment disk morphogenesis, may also play a role with ROM1 in the maintenance of outer segment disk structure. Required for the maintenance of retinal outer nuclear layer thickness. Required for the correct development and organization of the photoreceptor inner segment. Belongs to the PRPH2/ROM1 family. | Retbindin; Riboflavin-binding protein which might have a role in retinal flavin transport; Belongs to the folate receptor family. | 0.455 |
Prph2 | Slc24a1 | ENSMUSP00000024773 | ENSMUSP00000035616 | Peripherin-2; Essential for retina photoreceptor outer segment disk morphogenesis, may also play a role with ROM1 in the maintenance of outer segment disk structure. Required for the maintenance of retinal outer nuclear layer thickness. Required for the correct development and organization of the photoreceptor inner segment. Belongs to the PRPH2/ROM1 family. | Solute carrier family 24 (Sodium/potassium/calcium exchanger), member 1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. | 0.400 |
Rho | Prph2 | ENSMUSP00000032471 | ENSMUSP00000024773 | Rhodopsin; Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling. | Peripherin-2; Essential for retina photoreceptor outer segment disk morphogenesis, may also play a role with ROM1 in the maintenance of outer segment disk structure. Required for the maintenance of retinal outer nuclear layer thickness. Required for the correct development and organization of the photoreceptor inner segment. Belongs to the PRPH2/ROM1 family. | 0.869 |
Rho | Rtbdn | ENSMUSP00000032471 | ENSMUSP00000070558 | Rhodopsin; Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling. | Retbindin; Riboflavin-binding protein which might have a role in retinal flavin transport; Belongs to the folate receptor family. | 0.569 |
Rho | Slc24a1 | ENSMUSP00000032471 | ENSMUSP00000035616 | Rhodopsin; Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling. | Solute carrier family 24 (Sodium/potassium/calcium exchanger), member 1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. | 0.574 |
Rtbdn | Ankrd33 | ENSMUSP00000070558 | ENSMUSP00000067028 | Retbindin; Riboflavin-binding protein which might have a role in retinal flavin transport; Belongs to the folate receptor family. | Photoreceptor ankyrin repeat protein; [Isoform 1]: Acts as a transcriptional repressor for CRX- activated photoreceptor gene regulation. | 0.480 |
Rtbdn | Best2 | ENSMUSP00000070558 | ENSMUSP00000147837 | Retbindin; Riboflavin-binding protein which might have a role in retinal flavin transport; Belongs to the folate receptor family. | Bestrophin-2; Forms calcium-sensitive chloride channels. Permeable to bicarbonate. | 0.520 |
Rtbdn | Flad1 | ENSMUSP00000070558 | ENSMUSP00000122252 | Retbindin; Riboflavin-binding protein which might have a role in retinal flavin transport; Belongs to the folate receptor family. | Molybdenum cofactor biosynthesis protein-like region; Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme; In the C-terminal section; belongs to the PAPS reductase family. FAD1 subfamily. | 0.464 |
Rtbdn | Guca2b | ENSMUSP00000070558 | ENSMUSP00000043203 | Retbindin; Riboflavin-binding protein which might have a role in retinal flavin transport; Belongs to the folate receptor family. | Guanylate cyclase activator 2B; Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport (By similarity). | 0.516 |
Rtbdn | Gucy1a2 | ENSMUSP00000070558 | ENSMUSP00000111398 | Retbindin; Riboflavin-binding protein which might have a role in retinal flavin transport; Belongs to the folate receptor family. | Guanylate cyclase 1, soluble, alpha 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. | 0.545 |