node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
1700010B08Rik | Fndc8 | ENSMUSP00000072830 | ENSMUSP00000018988 | RIKEN cDNA 1700010B08 gene. | Fibronectin type III domain-containing protein 8. | 0.656 |
1700010B08Rik | Scp2d1 | ENSMUSP00000072830 | ENSMUSP00000028918 | RIKEN cDNA 1700010B08 gene. | SCP2 sterol-binding domain-containing protein 1. | 0.514 |
1700010B08Rik | Ube2d2b | ENSMUSP00000072830 | ENSMUSP00000072387 | RIKEN cDNA 1700010B08 gene. | Ubiquitin-conjugating enzyme E2 D2B; Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection (By similarity [...] | 0.683 |
1700010B08Rik | Ubqln5 | ENSMUSP00000072830 | ENSMUSP00000062054 | RIKEN cDNA 1700010B08 gene. | Ubiquilin 5. | 0.805 |
Brca1 | Rbx1 | ENSMUSP00000017290 | ENSMUSP00000023036 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | E3 ubiquitin-protein ligase RBX1, N-terminally processed; E3 ubiquitin ligase component of multiple cullin-RING-based E3 ubiquitin-protein ligase (CRLs) complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins, including proteins involved in cell cycle progression, signal transduction, transcription and transcription-coupled nucleotide excision repair. CRLs complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins, ARIH1 mediating addition of the first ubiquitin on CRLs targets (By similarity). The functional spec [...] | 0.821 |
Brca1 | Ube2d2b | ENSMUSP00000017290 | ENSMUSP00000072387 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | Ubiquitin-conjugating enzyme E2 D2B; Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection (By similarity [...] | 0.737 |
Fndc8 | 1700010B08Rik | ENSMUSP00000018988 | ENSMUSP00000072830 | Fibronectin type III domain-containing protein 8. | RIKEN cDNA 1700010B08 gene. | 0.656 |
Fndc8 | Scp2d1 | ENSMUSP00000018988 | ENSMUSP00000028918 | Fibronectin type III domain-containing protein 8. | SCP2 sterol-binding domain-containing protein 1. | 0.717 |
Fndc8 | Ube2d2b | ENSMUSP00000018988 | ENSMUSP00000072387 | Fibronectin type III domain-containing protein 8. | Ubiquitin-conjugating enzyme E2 D2B; Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection (By similarity [...] | 0.653 |
Fndc8 | Ubqln5 | ENSMUSP00000018988 | ENSMUSP00000062054 | Fibronectin type III domain-containing protein 8. | Ubiquilin 5. | 0.779 |
Gm20431 | Stub1 | ENSMUSP00000118416 | ENSMUSP00000040431 | Predicted gene 20431. | STIP1 homology and U box-containing protein 1; E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation. Collaborates with ATXN3 in the degradation of misfolded chaperone substrates: ATXN3 restricting the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension. Ubiquitinates NOS1 in concert with Hsp70 and Hsp40. Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90. Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 de [...] | 0.827 |
Gm20431 | Ube2d2b | ENSMUSP00000118416 | ENSMUSP00000072387 | Predicted gene 20431. | Ubiquitin-conjugating enzyme E2 D2B; Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection (By similarity [...] | 0.638 |
Gm20431 | Ube2v1 | ENSMUSP00000118416 | ENSMUSP00000114764 | Predicted gene 20431. | Ubiquitin-conjugating enzyme E2 variant 1. | 0.418 |
Gm20431 | Ubqln5 | ENSMUSP00000118416 | ENSMUSP00000062054 | Predicted gene 20431. | Ubiquilin 5. | 0.602 |
Rbx1 | Brca1 | ENSMUSP00000023036 | ENSMUSP00000017290 | E3 ubiquitin-protein ligase RBX1, N-terminally processed; E3 ubiquitin ligase component of multiple cullin-RING-based E3 ubiquitin-protein ligase (CRLs) complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins, including proteins involved in cell cycle progression, signal transduction, transcription and transcription-coupled nucleotide excision repair. CRLs complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins, ARIH1 mediating addition of the first ubiquitin on CRLs targets (By similarity). The functional spec [...] | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | 0.821 |
Rbx1 | Stub1 | ENSMUSP00000023036 | ENSMUSP00000040431 | E3 ubiquitin-protein ligase RBX1, N-terminally processed; E3 ubiquitin ligase component of multiple cullin-RING-based E3 ubiquitin-protein ligase (CRLs) complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins, including proteins involved in cell cycle progression, signal transduction, transcription and transcription-coupled nucleotide excision repair. CRLs complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins, ARIH1 mediating addition of the first ubiquitin on CRLs targets (By similarity). The functional spec [...] | STIP1 homology and U box-containing protein 1; E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation. Collaborates with ATXN3 in the degradation of misfolded chaperone substrates: ATXN3 restricting the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension. Ubiquitinates NOS1 in concert with Hsp70 and Hsp40. Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90. Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 de [...] | 0.418 |
Rbx1 | Ube2d2b | ENSMUSP00000023036 | ENSMUSP00000072387 | E3 ubiquitin-protein ligase RBX1, N-terminally processed; E3 ubiquitin ligase component of multiple cullin-RING-based E3 ubiquitin-protein ligase (CRLs) complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins, including proteins involved in cell cycle progression, signal transduction, transcription and transcription-coupled nucleotide excision repair. CRLs complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins, ARIH1 mediating addition of the first ubiquitin on CRLs targets (By similarity). The functional spec [...] | Ubiquitin-conjugating enzyme E2 D2B; Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection (By similarity [...] | 0.742 |
Scp2d1 | 1700010B08Rik | ENSMUSP00000028918 | ENSMUSP00000072830 | SCP2 sterol-binding domain-containing protein 1. | RIKEN cDNA 1700010B08 gene. | 0.514 |
Scp2d1 | Fndc8 | ENSMUSP00000028918 | ENSMUSP00000018988 | SCP2 sterol-binding domain-containing protein 1. | Fibronectin type III domain-containing protein 8. | 0.717 |
Scp2d1 | Ube2d2b | ENSMUSP00000028918 | ENSMUSP00000072387 | SCP2 sterol-binding domain-containing protein 1. | Ubiquitin-conjugating enzyme E2 D2B; Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection (By similarity [...] | 0.703 |