node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Arfgef2 | Arl1 | ENSMUSP00000096677 | ENSMUSP00000111942 | Brefeldin A-inhibited guanine nucleotide-exchange protein 2; Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extent on ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP. Involved in the regulation of Golgi vesicular transport. Required for the integrity of the endosomal compartment. Involved in trafficking from the trans-Golgi network (TGN) to endosomes and is required for membrane association of the AP-1 complex and GGA1. Seems to be involved in recycling of the transferrin receptor from recycling endosomes to the plasma [...] | ADP-ribosylation factor-like protein 1; GTP-binding protein. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus (By similarity). | 0.776 |
Arfgef2 | Mon2 | ENSMUSP00000096677 | ENSMUSP00000073462 | Brefeldin A-inhibited guanine nucleotide-exchange protein 2; Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extent on ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP. Involved in the regulation of Golgi vesicular transport. Required for the integrity of the endosomal compartment. Involved in trafficking from the trans-Golgi network (TGN) to endosomes and is required for membrane association of the AP-1 complex and GGA1. Seems to be involved in recycling of the transferrin receptor from recycling endosomes to the plasma [...] | Protein MON2 homolog; May be required for traffic between late Golgi and early endosomes; Belongs to the MON2 family. | 0.657 |
Arfrp1 | Arl1 | ENSMUSP00000122066 | ENSMUSP00000111942 | ADP-ribosylation factor-related protein 1; Trans-Golgi-associated GTPase that regulates protein sorting. Controls the targeting of ARL1 and its effector to the trans-Golgi. Required for the lipidation of chylomicrons in the intestine and required for VLDL lipidation in the liver. Belongs to the small GTPase superfamily. Arf family. | ADP-ribosylation factor-like protein 1; GTP-binding protein. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus (By similarity). | 0.675 |
Arfrp1 | Mon2 | ENSMUSP00000122066 | ENSMUSP00000073462 | ADP-ribosylation factor-related protein 1; Trans-Golgi-associated GTPase that regulates protein sorting. Controls the targeting of ARL1 and its effector to the trans-Golgi. Required for the lipidation of chylomicrons in the intestine and required for VLDL lipidation in the liver. Belongs to the small GTPase superfamily. Arf family. | Protein MON2 homolog; May be required for traffic between late Golgi and early endosomes; Belongs to the MON2 family. | 0.634 |
Arfrp1 | Ric1 | ENSMUSP00000122066 | ENSMUSP00000043437 | ADP-ribosylation factor-related protein 1; Trans-Golgi-associated GTPase that regulates protein sorting. Controls the targeting of ARL1 and its effector to the trans-Golgi. Required for the lipidation of chylomicrons in the intestine and required for VLDL lipidation in the liver. Belongs to the small GTPase superfamily. Arf family. | RAB6A-GEF complex partner protein 1; The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP and may thereby required for efficient fusion of endosome-derived vesicles with the Golgi compartment. The RIC1-RGP1 complex participates in the recycling of mannose-6-phosphate receptors. Required for phosphorylation and localization of GJA1. | 0.782 |
Arl1 | Arfgef2 | ENSMUSP00000111942 | ENSMUSP00000096677 | ADP-ribosylation factor-like protein 1; GTP-binding protein. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus (By similarity). | Brefeldin A-inhibited guanine nucleotide-exchange protein 2; Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extent on ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP. Involved in the regulation of Golgi vesicular transport. Required for the integrity of the endosomal compartment. Involved in trafficking from the trans-Golgi network (TGN) to endosomes and is required for membrane association of the AP-1 complex and GGA1. Seems to be involved in recycling of the transferrin receptor from recycling endosomes to the plasma [...] | 0.776 |
Arl1 | Arfrp1 | ENSMUSP00000111942 | ENSMUSP00000122066 | ADP-ribosylation factor-like protein 1; GTP-binding protein. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus (By similarity). | ADP-ribosylation factor-related protein 1; Trans-Golgi-associated GTPase that regulates protein sorting. Controls the targeting of ARL1 and its effector to the trans-Golgi. Required for the lipidation of chylomicrons in the intestine and required for VLDL lipidation in the liver. Belongs to the small GTPase superfamily. Arf family. | 0.675 |
Arl1 | Mon2 | ENSMUSP00000111942 | ENSMUSP00000073462 | ADP-ribosylation factor-like protein 1; GTP-binding protein. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus (By similarity). | Protein MON2 homolog; May be required for traffic between late Golgi and early endosomes; Belongs to the MON2 family. | 0.712 |
Arl1 | Ric1 | ENSMUSP00000111942 | ENSMUSP00000043437 | ADP-ribosylation factor-like protein 1; GTP-binding protein. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus (By similarity). | RAB6A-GEF complex partner protein 1; The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP and may thereby required for efficient fusion of endosome-derived vesicles with the Golgi compartment. The RIC1-RGP1 complex participates in the recycling of mannose-6-phosphate receptors. Required for phosphorylation and localization of GJA1. | 0.619 |
Atp9b | Dop1b | ENSMUSP00000153157 | ENSMUSP00000044437 | Probable phospholipid-transporting ATPase IIB; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. | Protein dopey-2; May be involved in protein traffic between late Golgi and early endosomes. | 0.433 |
Atp9b | Mon2 | ENSMUSP00000153157 | ENSMUSP00000073462 | Probable phospholipid-transporting ATPase IIB; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. | Protein MON2 homolog; May be required for traffic between late Golgi and early endosomes; Belongs to the MON2 family. | 0.661 |
Dop1a | Mon2 | ENSMUSP00000140740 | ENSMUSP00000073462 | Protein dopey-1; May be involved in protein traffic between late Golgi and early endosomes. | Protein MON2 homolog; May be required for traffic between late Golgi and early endosomes; Belongs to the MON2 family. | 0.940 |
Dop1b | Atp9b | ENSMUSP00000044437 | ENSMUSP00000153157 | Protein dopey-2; May be involved in protein traffic between late Golgi and early endosomes. | Probable phospholipid-transporting ATPase IIB; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. | 0.433 |
Dop1b | Mon2 | ENSMUSP00000044437 | ENSMUSP00000073462 | Protein dopey-2; May be involved in protein traffic between late Golgi and early endosomes. | Protein MON2 homolog; May be required for traffic between late Golgi and early endosomes; Belongs to the MON2 family. | 0.893 |
Fbxo38 | Mon2 | ENSMUSP00000047541 | ENSMUSP00000073462 | F-box only protein 38; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of PDCD1/PD-1, thereby regulating T-cells-mediated immunity. Required for anti-tumor activity of T-cells by promoting the degradation of PDCD1/PD-1; the PDCD1-mediated inhibitory pathway being exploited by tumors to attenuate anti-tumor immunity and facilitate tumor survival. May indirectly stimulate the activity of transcription factor KLF7, a regulator of neuronal differentiation, without [...] | Protein MON2 homolog; May be required for traffic between late Golgi and early endosomes; Belongs to the MON2 family. | 0.701 |
Mon2 | Arfgef2 | ENSMUSP00000073462 | ENSMUSP00000096677 | Protein MON2 homolog; May be required for traffic between late Golgi and early endosomes; Belongs to the MON2 family. | Brefeldin A-inhibited guanine nucleotide-exchange protein 2; Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extent on ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP. Involved in the regulation of Golgi vesicular transport. Required for the integrity of the endosomal compartment. Involved in trafficking from the trans-Golgi network (TGN) to endosomes and is required for membrane association of the AP-1 complex and GGA1. Seems to be involved in recycling of the transferrin receptor from recycling endosomes to the plasma [...] | 0.657 |
Mon2 | Arfrp1 | ENSMUSP00000073462 | ENSMUSP00000122066 | Protein MON2 homolog; May be required for traffic between late Golgi and early endosomes; Belongs to the MON2 family. | ADP-ribosylation factor-related protein 1; Trans-Golgi-associated GTPase that regulates protein sorting. Controls the targeting of ARL1 and its effector to the trans-Golgi. Required for the lipidation of chylomicrons in the intestine and required for VLDL lipidation in the liver. Belongs to the small GTPase superfamily. Arf family. | 0.634 |
Mon2 | Arl1 | ENSMUSP00000073462 | ENSMUSP00000111942 | Protein MON2 homolog; May be required for traffic between late Golgi and early endosomes; Belongs to the MON2 family. | ADP-ribosylation factor-like protein 1; GTP-binding protein. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus (By similarity). | 0.712 |
Mon2 | Atp9b | ENSMUSP00000073462 | ENSMUSP00000153157 | Protein MON2 homolog; May be required for traffic between late Golgi and early endosomes; Belongs to the MON2 family. | Probable phospholipid-transporting ATPase IIB; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. | 0.661 |
Mon2 | Dop1a | ENSMUSP00000073462 | ENSMUSP00000140740 | Protein MON2 homolog; May be required for traffic between late Golgi and early endosomes; Belongs to the MON2 family. | Protein dopey-1; May be involved in protein traffic between late Golgi and early endosomes. | 0.940 |