Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-expression
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[Homology]
Score
Zfp35Zinc finger protein 271; May act to control gene activity during the pachytene stage of meiotic prophase. May function as a transcription activator. (580 aa)    
Predicted Functional Partners:
Ccdc7b
Coiled-coil domain-containing 7B.
   
  
 0.667
4931406B18Rik
RIKEN cDNA 4931406B18 gene.
      
 0.603
Trim28
Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...]
   
  0.542
Prorsd1
Prolyl-tRNA synthetase associated domain-containing protein 1.
   
  
 0.539
Gm4787
Predicted gene, EG214321.
   
  
 0.509
Tmem198b
Transmembrane protein 198b.
   
 
 0.507
Cwf19l1
CWF19-like protein 1.
   
    0.497
Smco1
Single-pass membrane and coiled-coil domain-containing protein 1.
      
 0.492
Arl6ip6
ADP-ribosylation factor-like protein 6-interacting protein 6.
   
  
 0.484
Prss40
Serine protease 40; May play an important role in the sperm/egg interaction; released during the acrosome reaction; Belongs to the peptidase S1 family.
    
 
 0.480
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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