node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Atxn2l | Helz | ENSMUSP00000035415 | ENSMUSP00000074533 | Ataxin-2-like protein; Involved in the regulation of stress granule and P-body formation. | Probable helicase with zinc finger domain; May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo. | 0.555 |
Atxn2l | Rc3h2 | ENSMUSP00000035415 | ENSMUSP00000097721 | Ataxin-2-like protein; Involved in the regulation of stress granule and P-body formation. | Roquin-2; Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF and in many more mRNAs. Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs. In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity. In resting or LPS-stimul [...] | 0.548 |
Cnot1 | Helz | ENSMUSP00000148807 | ENSMUSP00000074533 | CCR4-NOT transcription complex subunit 1; Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRN [...] | Probable helicase with zinc finger domain; May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo. | 0.674 |
Cnot1 | Rc3h2 | ENSMUSP00000148807 | ENSMUSP00000097721 | CCR4-NOT transcription complex subunit 1; Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRN [...] | Roquin-2; Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF and in many more mRNAs. Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs. In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity. In resting or LPS-stimul [...] | 0.740 |
Gtf2e2 | Helz | ENSMUSP00000132287 | ENSMUSP00000074533 | General transcription factor IIE subunit 2; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase (By similarity). Belongs to the TFIIE beta subunit family. | Probable helicase with zinc finger domain; May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo. | 0.498 |
Gtf2e2 | Lyrm9 | ENSMUSP00000132287 | ENSMUSP00000127853 | General transcription factor IIE subunit 2; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase (By similarity). Belongs to the TFIIE beta subunit family. | LYR motif-containing protein 9; Belongs to the complex I LYR family. LYRM9 subfamily. | 0.497 |
Helz | Atxn2l | ENSMUSP00000074533 | ENSMUSP00000035415 | Probable helicase with zinc finger domain; May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo. | Ataxin-2-like protein; Involved in the regulation of stress granule and P-body formation. | 0.555 |
Helz | Cnot1 | ENSMUSP00000074533 | ENSMUSP00000148807 | Probable helicase with zinc finger domain; May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo. | CCR4-NOT transcription complex subunit 1; Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRN [...] | 0.674 |
Helz | Gtf2e2 | ENSMUSP00000074533 | ENSMUSP00000132287 | Probable helicase with zinc finger domain; May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo. | General transcription factor IIE subunit 2; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase (By similarity). Belongs to the TFIIE beta subunit family. | 0.498 |
Helz | Lyrm9 | ENSMUSP00000074533 | ENSMUSP00000127853 | Probable helicase with zinc finger domain; May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo. | LYR motif-containing protein 9; Belongs to the complex I LYR family. LYRM9 subfamily. | 0.520 |
Helz | Optc | ENSMUSP00000074533 | ENSMUSP00000120568 | Probable helicase with zinc finger domain; May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo. | Opticin; Inhibits angiogenesis in the vitreous humor of the eye, and therefore represses neovascularization. Binds collagen fibrils (By similarity). May be involved in collagen fiber organization via regulation of other members of the small leucine-rich repeat proteoglycan superfamily. | 0.536 |
Helz | Phf3 | ENSMUSP00000074533 | ENSMUSP00000139610 | Probable helicase with zinc finger domain; May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo. | PHD finger protein 3. | 0.602 |
Helz | Pitpnc1 | ENSMUSP00000074533 | ENSMUSP00000099353 | Probable helicase with zinc finger domain; May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo. | Cytoplasmic phosphatidylinositol transfer protein 1; Phosphatidylinositol transfer proteins mediate the monomeric transport of lipids by shielding a lipid from the aqueous environment and binding the lipid in a hydrophobic cavity. Able to transfer phosphatidylinositol in vitro. Isoform 2 specifically binds to phosphatidylinositol but not to other phospholipids and may play a role in the phosphoinositide-mediated signaling in the neural development. | 0.609 |
Helz | Rc3h2 | ENSMUSP00000074533 | ENSMUSP00000097721 | Probable helicase with zinc finger domain; May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo. | Roquin-2; Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF and in many more mRNAs. Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs. In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity. In resting or LPS-stimul [...] | 0.616 |
Helz | Smyd2 | ENSMUSP00000074533 | ENSMUSP00000027897 | Probable helicase with zinc finger domain; May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo. | N-lysine methyltransferase SMYD2; Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically trimethylates histone H3 'Lys-4' (H3K4me3) in vivo. The activity requires interaction with HSP90alpha. Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'; Belongs to the class V-like SAM-binding methyltransferase superfamily. | 0.680 |
Helz | Smyd3 | ENSMUSP00000074533 | ENSMUSP00000117410 | Probable helicase with zinc finger domain; May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo. | Histone-lysine N-methyltransferase SMYD3; Histone methyltransferase. Specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. Also methylates 'Lys-5' of histone H4. Plays an important role in transcriptional activation as a member of an RNA polymerase complex. Binds DNA containing 5'-CCCTCC-3' or 5'-GAGGGG-3' sequences. | 0.800 |
Lyrm9 | Gtf2e2 | ENSMUSP00000127853 | ENSMUSP00000132287 | LYR motif-containing protein 9; Belongs to the complex I LYR family. LYRM9 subfamily. | General transcription factor IIE subunit 2; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase (By similarity). Belongs to the TFIIE beta subunit family. | 0.497 |
Lyrm9 | Helz | ENSMUSP00000127853 | ENSMUSP00000074533 | LYR motif-containing protein 9; Belongs to the complex I LYR family. LYRM9 subfamily. | Probable helicase with zinc finger domain; May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo. | 0.520 |
Optc | Helz | ENSMUSP00000120568 | ENSMUSP00000074533 | Opticin; Inhibits angiogenesis in the vitreous humor of the eye, and therefore represses neovascularization. Binds collagen fibrils (By similarity). May be involved in collagen fiber organization via regulation of other members of the small leucine-rich repeat proteoglycan superfamily. | Probable helicase with zinc finger domain; May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo. | 0.536 |
Phf3 | Helz | ENSMUSP00000139610 | ENSMUSP00000074533 | PHD finger protein 3. | Probable helicase with zinc finger domain; May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo. | 0.602 |