STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Defa34Defensin, alpha, 34. (93 aa)    
Predicted Functional Partners:
Cd4
T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]
     
  0.499
Defa37
Defensin, alpha, 36.
   
 
0.477
Defa21
Alpha-defensin 21; May have microbicidal activities; Belongs to the alpha-defensin family.
   
 
0.476
Defa40
Defensin, alpha, 40.
   
 
0.473
Defa41
Defensin, alpha, 41.
   
 
 
0.470
Defa26
Alpha-defensin 26; May have microbicidal activities; Belongs to the alpha-defensin family.
   
 
0.469
Defa24
Alpha-defensin 24; May have microbicidal activities; Belongs to the alpha-defensin family.
   
 
0.467
Defa32
Alpha-defensin 20; May have microbicidal activities; Belongs to the alpha-defensin family.
   
 
0.467
Defa17
Alpha-defensin 3; Probably contributes to the antimicrobial barrier function of the small bowel mucosa.
   
 
0.465
Defa30
Defensin, alpha, 30.
   
 
0.462
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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