STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Dgcr6Protein DGCR6; May have a role in early embryogenesis; Belongs to the gonadal family. (201 aa)    
Predicted Functional Partners:
Ufd1
Ubiquitin recognition factor in ER-associated degradation protein 1; Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1- VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-deriv [...]
   
  
 0.713
Prodh
Proline dehydrogenase 1, mitochondrial; Converts proline to delta-1-pyrroline-5-carboxylate.
   
  
 0.680
Mrpl40
39S ribosomal protein L40, mitochondrial.
   
  
 0.606
Gnb1l
Guanine nucleotide-binding protein subunit beta-like protein 1.
   
  
 0.591
Abhd16b
Protein ABHD16B; Belongs to the AB hydrolase superfamily. ABHD16 family.
      
 0.539
Dgcr2
Integral membrane protein DGCR2/IDD; Probably plays a role in neural crest cell migration. May play a role in delivery of extracellular signals.
   
  
 0.513
Zdhhc8
Probable palmitoyltransferase ZDHHC8; Palmitoyltransferase involved in glutamatergic transmission. Mediates palmitoylation of ABCA1; Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.
   
  
 0.485
Tango2
Transport and Golgi organization 2 homolog.
   
  
 0.484
Phpt1
14 kDa phosphohistidine phosphatase; Exhibits phosphohistidine phosphatase activity.
   
  
 0.478
Dtd1
D-aminoacyl-tRNA deacylase 1; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality.
   
  
 0.466
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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