node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Astl | Lyzl4 | ENSMUSP00000087102 | ENSMUSP00000076887 | Astacin-like metalloendopeptidase; Oocyte-specific oolemmal receptor involved in sperm and egg adhesion and fertilization. Plays a role in the polyspermy inhibition. Probably acts as a protease for the post-fertilization cleavage of ZP2. Cleaves the sperm-binding ZP2 at the surface of the zona pellucida after fertilization and cortical granule exocytosis, rendering the zona pellucida unable to support further sperm binding. | Lysozyme-like protein 4; May be involved in fertilization. Has no detectable bacteriolytic in vitro. Has no lysozyme activity in vitro (By similarity). | 0.439 |
Csn2 | Lyzl4 | ENSMUSP00000143341 | ENSMUSP00000076887 | Beta-casein; Important role in determination of the surface properties of the casein micelles. | Lysozyme-like protein 4; May be involved in fertilization. Has no detectable bacteriolytic in vitro. Has no lysozyme activity in vitro (By similarity). | 0.436 |
Dusp13 | Lyzl4 | ENSMUSP00000113305 | ENSMUSP00000076887 | Dual specificity protein phosphatase 13 isoform B; Dual specificity phosphatase that dephosphorylates MAPK8/JNK and MAPK14/p38, but not MAPK1/ERK2, in vitro. Exhibits intrinsic phosphatase activity towards both phospho-seryl/threonyl and -tyrosyl residues, with similar specific activities in vitro (By similarity). Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | Lysozyme-like protein 4; May be involved in fertilization. Has no detectable bacteriolytic in vitro. Has no lysozyme activity in vitro (By similarity). | 0.455 |
Gls2 | Lyzl4 | ENSMUSP00000047376 | ENSMUSP00000076887 | Glutaminase liver isoform, mitochondrial; Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha- ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation. | Lysozyme-like protein 4; May be involved in fertilization. Has no detectable bacteriolytic in vitro. Has no lysozyme activity in vitro (By similarity). | 0.514 |
Gls2 | Mip | ENSMUSP00000047376 | ENSMUSP00000026455 | Glutaminase liver isoform, mitochondrial; Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha- ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation. | Lens fiber major intrinsic protein; Water channel. Channel activity is down-regulated by CALM when cytoplasmic Ca(2+) levels are increased. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core. Plays a role in cell-to-cell adhesion and facilitates gap junction coupling (By similarity). Belongs to the MIP/aquaporin (TC 1.A.8) family. | 0.525 |
Gls2 | Yeats4 | ENSMUSP00000047376 | ENSMUSP00000020382 | Glutaminase liver isoform, mitochondrial; Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha- ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation. | YEATS domain-containing protein 4; Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and repl [...] | 0.461 |
Gm45623 | Lyzl4 | ENSMUSP00000147916 | ENSMUSP00000076887 | Predicted gene 45623. | Lysozyme-like protein 4; May be involved in fertilization. Has no detectable bacteriolytic in vitro. Has no lysozyme activity in vitro (By similarity). | 0.466 |
Gm45623 | Rasgef1c | ENSMUSP00000147916 | ENSMUSP00000065619 | Predicted gene 45623. | Ras-GEF domain-containing family member 1C; Guanine nucleotide exchange factor (GEF). | 0.443 |
Lcn6 | Lyzl4 | ENSMUSP00000109837 | ENSMUSP00000076887 | LCN6 isoform alpha; Belongs to the calycin superfamily. Lipocalin family. | Lysozyme-like protein 4; May be involved in fertilization. Has no detectable bacteriolytic in vitro. Has no lysozyme activity in vitro (By similarity). | 0.523 |
Lyzl4 | Astl | ENSMUSP00000076887 | ENSMUSP00000087102 | Lysozyme-like protein 4; May be involved in fertilization. Has no detectable bacteriolytic in vitro. Has no lysozyme activity in vitro (By similarity). | Astacin-like metalloendopeptidase; Oocyte-specific oolemmal receptor involved in sperm and egg adhesion and fertilization. Plays a role in the polyspermy inhibition. Probably acts as a protease for the post-fertilization cleavage of ZP2. Cleaves the sperm-binding ZP2 at the surface of the zona pellucida after fertilization and cortical granule exocytosis, rendering the zona pellucida unable to support further sperm binding. | 0.439 |
Lyzl4 | Csn2 | ENSMUSP00000076887 | ENSMUSP00000143341 | Lysozyme-like protein 4; May be involved in fertilization. Has no detectable bacteriolytic in vitro. Has no lysozyme activity in vitro (By similarity). | Beta-casein; Important role in determination of the surface properties of the casein micelles. | 0.436 |
Lyzl4 | Dusp13 | ENSMUSP00000076887 | ENSMUSP00000113305 | Lysozyme-like protein 4; May be involved in fertilization. Has no detectable bacteriolytic in vitro. Has no lysozyme activity in vitro (By similarity). | Dual specificity protein phosphatase 13 isoform B; Dual specificity phosphatase that dephosphorylates MAPK8/JNK and MAPK14/p38, but not MAPK1/ERK2, in vitro. Exhibits intrinsic phosphatase activity towards both phospho-seryl/threonyl and -tyrosyl residues, with similar specific activities in vitro (By similarity). Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | 0.455 |
Lyzl4 | Gls2 | ENSMUSP00000076887 | ENSMUSP00000047376 | Lysozyme-like protein 4; May be involved in fertilization. Has no detectable bacteriolytic in vitro. Has no lysozyme activity in vitro (By similarity). | Glutaminase liver isoform, mitochondrial; Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha- ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation. | 0.514 |
Lyzl4 | Gm45623 | ENSMUSP00000076887 | ENSMUSP00000147916 | Lysozyme-like protein 4; May be involved in fertilization. Has no detectable bacteriolytic in vitro. Has no lysozyme activity in vitro (By similarity). | Predicted gene 45623. | 0.466 |
Lyzl4 | Lcn6 | ENSMUSP00000076887 | ENSMUSP00000109837 | Lysozyme-like protein 4; May be involved in fertilization. Has no detectable bacteriolytic in vitro. Has no lysozyme activity in vitro (By similarity). | LCN6 isoform alpha; Belongs to the calycin superfamily. Lipocalin family. | 0.523 |
Lyzl4 | Mip | ENSMUSP00000076887 | ENSMUSP00000026455 | Lysozyme-like protein 4; May be involved in fertilization. Has no detectable bacteriolytic in vitro. Has no lysozyme activity in vitro (By similarity). | Lens fiber major intrinsic protein; Water channel. Channel activity is down-regulated by CALM when cytoplasmic Ca(2+) levels are increased. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core. Plays a role in cell-to-cell adhesion and facilitates gap junction coupling (By similarity). Belongs to the MIP/aquaporin (TC 1.A.8) family. | 0.468 |
Lyzl4 | Rasgef1c | ENSMUSP00000076887 | ENSMUSP00000065619 | Lysozyme-like protein 4; May be involved in fertilization. Has no detectable bacteriolytic in vitro. Has no lysozyme activity in vitro (By similarity). | Ras-GEF domain-containing family member 1C; Guanine nucleotide exchange factor (GEF). | 0.522 |
Lyzl4 | Spata2l | ENSMUSP00000076887 | ENSMUSP00000130306 | Lysozyme-like protein 4; May be involved in fertilization. Has no detectable bacteriolytic in vitro. Has no lysozyme activity in vitro (By similarity). | Spermatogenesis-associated protein 2-like protein. | 0.554 |
Lyzl4 | Yeats4 | ENSMUSP00000076887 | ENSMUSP00000020382 | Lysozyme-like protein 4; May be involved in fertilization. Has no detectable bacteriolytic in vitro. Has no lysozyme activity in vitro (By similarity). | YEATS domain-containing protein 4; Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and repl [...] | 0.597 |
Mip | Gls2 | ENSMUSP00000026455 | ENSMUSP00000047376 | Lens fiber major intrinsic protein; Water channel. Channel activity is down-regulated by CALM when cytoplasmic Ca(2+) levels are increased. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core. Plays a role in cell-to-cell adhesion and facilitates gap junction coupling (By similarity). Belongs to the MIP/aquaporin (TC 1.A.8) family. | Glutaminase liver isoform, mitochondrial; Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha- ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation. | 0.525 |