node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Dnajc18 | Fam118a | ENSMUSP00000025208 | ENSMUSP00000154985 | DnaJ homolog subfamily C member 18. | Protein FAM118A; Belongs to the FAM118 family. | 0.686 |
Dnajc18 | Letm2 | ENSMUSP00000025208 | ENSMUSP00000078160 | DnaJ homolog subfamily C member 18. | LETM1 domain-containing protein LETM2, mitochondrial. | 0.525 |
Dnajc18 | Pld6 | ENSMUSP00000025208 | ENSMUSP00000115503 | DnaJ homolog subfamily C member 18. | Mitochondrial cardiolipin hydrolase; Endonuclease that plays a critical role in PIWI-interacting RNA (piRNA) biogenesis during spermatogenesis. piRNAs provide essential protection against the activity of mobile genetic elements. piRNA- mediated transposon silencing is thus critical for maintaining genome stability, in particular in germline cells when transposons are mobilized as a consequence of wide-spread genomic demethylation. Has been proposed to act as a cardiolipin hydrolase to generate phosphatidic acid at mitochondrial surface. Although it cannot be excluded that it can act as [...] | 0.462 |
Dnajc18 | Reep6 | ENSMUSP00000025208 | ENSMUSP00000100991 | DnaJ homolog subfamily C member 18. | Receptor expression-enhancing protein 6; Required for correct function and survival of retinal photoreceptors. Required for retinal development. In rod photoreceptors, facilitates stability and/or trafficking of guanylate cyclases and is required to maintain endoplasmic reticulum and mitochondrial homeostasis. May play a role in clathrin-coated intracellular vesicle trafficking of proteins from the endoplasmic reticulum to the retinal rod plasma membrane. | 0.492 |
Dnajc18 | Rhbdd3 | ENSMUSP00000025208 | ENSMUSP00000099131 | DnaJ homolog subfamily C member 18. | Rhomboid domain-containing protein 3. | 0.533 |
Dnajc18 | Tmem39b | ENSMUSP00000025208 | ENSMUSP00000099648 | DnaJ homolog subfamily C member 18. | Transmembrane protein 39B. | 0.541 |
Fam118a | Dnajc18 | ENSMUSP00000154985 | ENSMUSP00000025208 | Protein FAM118A; Belongs to the FAM118 family. | DnaJ homolog subfamily C member 18. | 0.686 |
Fam118a | Letm2 | ENSMUSP00000154985 | ENSMUSP00000078160 | Protein FAM118A; Belongs to the FAM118 family. | LETM1 domain-containing protein LETM2, mitochondrial. | 0.651 |
Fam118a | Pld6 | ENSMUSP00000154985 | ENSMUSP00000115503 | Protein FAM118A; Belongs to the FAM118 family. | Mitochondrial cardiolipin hydrolase; Endonuclease that plays a critical role in PIWI-interacting RNA (piRNA) biogenesis during spermatogenesis. piRNAs provide essential protection against the activity of mobile genetic elements. piRNA- mediated transposon silencing is thus critical for maintaining genome stability, in particular in germline cells when transposons are mobilized as a consequence of wide-spread genomic demethylation. Has been proposed to act as a cardiolipin hydrolase to generate phosphatidic acid at mitochondrial surface. Although it cannot be excluded that it can act as [...] | 0.545 |
Fam118a | Reep6 | ENSMUSP00000154985 | ENSMUSP00000100991 | Protein FAM118A; Belongs to the FAM118 family. | Receptor expression-enhancing protein 6; Required for correct function and survival of retinal photoreceptors. Required for retinal development. In rod photoreceptors, facilitates stability and/or trafficking of guanylate cyclases and is required to maintain endoplasmic reticulum and mitochondrial homeostasis. May play a role in clathrin-coated intracellular vesicle trafficking of proteins from the endoplasmic reticulum to the retinal rod plasma membrane. | 0.544 |
Fam118a | Rhbdd3 | ENSMUSP00000154985 | ENSMUSP00000099131 | Protein FAM118A; Belongs to the FAM118 family. | Rhomboid domain-containing protein 3. | 0.671 |
Fam118a | Tmem39b | ENSMUSP00000154985 | ENSMUSP00000099648 | Protein FAM118A; Belongs to the FAM118 family. | Transmembrane protein 39B. | 0.664 |
Letm2 | Dnajc18 | ENSMUSP00000078160 | ENSMUSP00000025208 | LETM1 domain-containing protein LETM2, mitochondrial. | DnaJ homolog subfamily C member 18. | 0.525 |
Letm2 | Fam118a | ENSMUSP00000078160 | ENSMUSP00000154985 | LETM1 domain-containing protein LETM2, mitochondrial. | Protein FAM118A; Belongs to the FAM118 family. | 0.651 |
Letm2 | Micu1 | ENSMUSP00000078160 | ENSMUSP00000020311 | LETM1 domain-containing protein LETM2, mitochondrial. | Calcium uptake protein 1, mitochondrial; Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains. MICU1 and MICU2 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium. MICU1 acts both as an activator or inhibitor of mitochondrial calcium uptake (By similarity). Acts as a gatekeeper of MCU at low concentration of calcium, preventing channel opening (By similarity). Enhances MCU opening at high calcium concentration, allowing a rapid response of mitochondria to calcium sig [...] | 0.506 |
Letm2 | Nsd3 | ENSMUSP00000078160 | ENSMUSP00000117778 | LETM1 domain-containing protein LETM2, mitochondrial. | Histone-lysine N-methyltransferase NSD3; Histone methyltransferase. Preferentially dimethylates 'Lys- 4' and 'Lys-27' of histone H3 forming H3K2me2 and H3K27me2. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression. Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily. | 0.505 |
Letm2 | Pld6 | ENSMUSP00000078160 | ENSMUSP00000115503 | LETM1 domain-containing protein LETM2, mitochondrial. | Mitochondrial cardiolipin hydrolase; Endonuclease that plays a critical role in PIWI-interacting RNA (piRNA) biogenesis during spermatogenesis. piRNAs provide essential protection against the activity of mobile genetic elements. piRNA- mediated transposon silencing is thus critical for maintaining genome stability, in particular in germline cells when transposons are mobilized as a consequence of wide-spread genomic demethylation. Has been proposed to act as a cardiolipin hydrolase to generate phosphatidic acid at mitochondrial surface. Although it cannot be excluded that it can act as [...] | 0.523 |
Letm2 | Reep6 | ENSMUSP00000078160 | ENSMUSP00000100991 | LETM1 domain-containing protein LETM2, mitochondrial. | Receptor expression-enhancing protein 6; Required for correct function and survival of retinal photoreceptors. Required for retinal development. In rod photoreceptors, facilitates stability and/or trafficking of guanylate cyclases and is required to maintain endoplasmic reticulum and mitochondrial homeostasis. May play a role in clathrin-coated intracellular vesicle trafficking of proteins from the endoplasmic reticulum to the retinal rod plasma membrane. | 0.500 |
Letm2 | Rhbdd3 | ENSMUSP00000078160 | ENSMUSP00000099131 | LETM1 domain-containing protein LETM2, mitochondrial. | Rhomboid domain-containing protein 3. | 0.604 |
Letm2 | Rps11 | ENSMUSP00000078160 | ENSMUSP00000003521 | LETM1 domain-containing protein LETM2, mitochondrial. | 40S ribosomal protein S11. | 0.497 |