| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Ddhd2 | Letm2 | ENSMUSP00000033975 | ENSMUSP00000078160 | Phospholipase DDHD2; Phospholipase that hydrolyzes preferentially phosphatidic acid, including 1,2-dioleoyl-sn-phosphatidic acid, and phosphatidylethanolamine. Specifically binds to phosphatidylinositol 3- phosphate (PI(3)P), phosphatidylinositol 4-phosphate (PI(4)P), phosphatidylinositol 5-phosphate (PI(5)P) and possibly phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2). May be involved in the maintenance of the endoplasmic reticulum and/or Golgi structures. May regulate the transport between Golgi apparatus and plasma membrane (By similarity). | LETM1 domain-containing protein LETM2, mitochondrial. | 0.528 |
| Dnajc18 | Fam118a | ENSMUSP00000025208 | ENSMUSP00000154985 | DnaJ homolog subfamily C member 18. | Protein FAM118A; Belongs to the FAM118 family. | 0.668 |
| Dnajc18 | Letm2 | ENSMUSP00000025208 | ENSMUSP00000078160 | DnaJ homolog subfamily C member 18. | LETM1 domain-containing protein LETM2, mitochondrial. | 0.614 |
| Dnajc18 | Pld6 | ENSMUSP00000025208 | ENSMUSP00000115503 | DnaJ homolog subfamily C member 18. | Mitochondrial cardiolipin hydrolase; Endonuclease that plays a critical role in PIWI-interacting RNA (piRNA) biogenesis during spermatogenesis. piRNAs provide essential protection against the activity of mobile genetic elements. piRNA- mediated transposon silencing is thus critical for maintaining genome stability, in particular in germline cells when transposons are mobilized as a consequence of wide-spread genomic demethylation. Has been proposed to act as a cardiolipin hydrolase to generate phosphatidic acid at mitochondrial surface. Although it cannot be excluded that it can act as [...] | 0.456 |
| Dnajc18 | Reep6 | ENSMUSP00000025208 | ENSMUSP00000100991 | DnaJ homolog subfamily C member 18. | Receptor expression-enhancing protein 6; Required for correct function and survival of retinal photoreceptors. Required for retinal development. In rod photoreceptors, facilitates stability and/or trafficking of guanylate cyclases and is required to maintain endoplasmic reticulum and mitochondrial homeostasis. May play a role in clathrin-coated intracellular vesicle trafficking of proteins from the endoplasmic reticulum to the retinal rod plasma membrane. | 0.536 |
| Dnajc18 | Rhbdd3 | ENSMUSP00000025208 | ENSMUSP00000099131 | DnaJ homolog subfamily C member 18. | Rhomboid domain-containing protein 3. | 0.568 |
| Dnajc18 | Tmem39b | ENSMUSP00000025208 | ENSMUSP00000099648 | DnaJ homolog subfamily C member 18. | Transmembrane protein 39B. | 0.576 |
| Fam118a | Dnajc18 | ENSMUSP00000154985 | ENSMUSP00000025208 | Protein FAM118A; Belongs to the FAM118 family. | DnaJ homolog subfamily C member 18. | 0.668 |
| Fam118a | Gpat2 | ENSMUSP00000154985 | ENSMUSP00000049619 | Protein FAM118A; Belongs to the FAM118 family. | Glycerol-3-phosphate acyltransferase 2, mitochondrial; Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Required for primary processing step during piRNA biosynthesis. Molecular mechanisms by which it promotes piRNA biosynthesis are unclear and do not involve its acyltransferase activity. | 0.563 |
| Fam118a | Letm2 | ENSMUSP00000154985 | ENSMUSP00000078160 | Protein FAM118A; Belongs to the FAM118 family. | LETM1 domain-containing protein LETM2, mitochondrial. | 0.681 |
| Fam118a | Pld6 | ENSMUSP00000154985 | ENSMUSP00000115503 | Protein FAM118A; Belongs to the FAM118 family. | Mitochondrial cardiolipin hydrolase; Endonuclease that plays a critical role in PIWI-interacting RNA (piRNA) biogenesis during spermatogenesis. piRNAs provide essential protection against the activity of mobile genetic elements. piRNA- mediated transposon silencing is thus critical for maintaining genome stability, in particular in germline cells when transposons are mobilized as a consequence of wide-spread genomic demethylation. Has been proposed to act as a cardiolipin hydrolase to generate phosphatidic acid at mitochondrial surface. Although it cannot be excluded that it can act as [...] | 0.591 |
| Fam118a | Reep6 | ENSMUSP00000154985 | ENSMUSP00000100991 | Protein FAM118A; Belongs to the FAM118 family. | Receptor expression-enhancing protein 6; Required for correct function and survival of retinal photoreceptors. Required for retinal development. In rod photoreceptors, facilitates stability and/or trafficking of guanylate cyclases and is required to maintain endoplasmic reticulum and mitochondrial homeostasis. May play a role in clathrin-coated intracellular vesicle trafficking of proteins from the endoplasmic reticulum to the retinal rod plasma membrane. | 0.544 |
| Fam118a | Rhbdd3 | ENSMUSP00000154985 | ENSMUSP00000099131 | Protein FAM118A; Belongs to the FAM118 family. | Rhomboid domain-containing protein 3. | 0.696 |
| Fam118a | Tmem39b | ENSMUSP00000154985 | ENSMUSP00000099648 | Protein FAM118A; Belongs to the FAM118 family. | Transmembrane protein 39B. | 0.658 |
| Gpat2 | Fam118a | ENSMUSP00000049619 | ENSMUSP00000154985 | Glycerol-3-phosphate acyltransferase 2, mitochondrial; Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Required for primary processing step during piRNA biosynthesis. Molecular mechanisms by which it promotes piRNA biosynthesis are unclear and do not involve its acyltransferase activity. | Protein FAM118A; Belongs to the FAM118 family. | 0.563 |
| Gpat2 | Letm2 | ENSMUSP00000049619 | ENSMUSP00000078160 | Glycerol-3-phosphate acyltransferase 2, mitochondrial; Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Required for primary processing step during piRNA biosynthesis. Molecular mechanisms by which it promotes piRNA biosynthesis are unclear and do not involve its acyltransferase activity. | LETM1 domain-containing protein LETM2, mitochondrial. | 0.536 |
| Gpat2 | Pld6 | ENSMUSP00000049619 | ENSMUSP00000115503 | Glycerol-3-phosphate acyltransferase 2, mitochondrial; Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Required for primary processing step during piRNA biosynthesis. Molecular mechanisms by which it promotes piRNA biosynthesis are unclear and do not involve its acyltransferase activity. | Mitochondrial cardiolipin hydrolase; Endonuclease that plays a critical role in PIWI-interacting RNA (piRNA) biogenesis during spermatogenesis. piRNAs provide essential protection against the activity of mobile genetic elements. piRNA- mediated transposon silencing is thus critical for maintaining genome stability, in particular in germline cells when transposons are mobilized as a consequence of wide-spread genomic demethylation. Has been proposed to act as a cardiolipin hydrolase to generate phosphatidic acid at mitochondrial surface. Although it cannot be excluded that it can act as [...] | 0.651 |
| Gpat2 | Rhbdd3 | ENSMUSP00000049619 | ENSMUSP00000099131 | Glycerol-3-phosphate acyltransferase 2, mitochondrial; Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Required for primary processing step during piRNA biosynthesis. Molecular mechanisms by which it promotes piRNA biosynthesis are unclear and do not involve its acyltransferase activity. | Rhomboid domain-containing protein 3. | 0.409 |
| Gpat2 | Tmem39b | ENSMUSP00000049619 | ENSMUSP00000099648 | Glycerol-3-phosphate acyltransferase 2, mitochondrial; Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Required for primary processing step during piRNA biosynthesis. Molecular mechanisms by which it promotes piRNA biosynthesis are unclear and do not involve its acyltransferase activity. | Transmembrane protein 39B. | 0.406 |
| Letm2 | Ddhd2 | ENSMUSP00000078160 | ENSMUSP00000033975 | LETM1 domain-containing protein LETM2, mitochondrial. | Phospholipase DDHD2; Phospholipase that hydrolyzes preferentially phosphatidic acid, including 1,2-dioleoyl-sn-phosphatidic acid, and phosphatidylethanolamine. Specifically binds to phosphatidylinositol 3- phosphate (PI(3)P), phosphatidylinositol 4-phosphate (PI(4)P), phosphatidylinositol 5-phosphate (PI(5)P) and possibly phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2). May be involved in the maintenance of the endoplasmic reticulum and/or Golgi structures. May regulate the transport between Golgi apparatus and plasma membrane (By similarity). | 0.528 |
