Stfa2l1 protein (mouse) - STRING interaction network

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Predicted Interactions

gene neighborhood

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textmining

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Score

Stfa2l1

Stefin-2; This is an intracellular thiol proteinase inhibitor. (103 aa)

Predicted Functional Partners:

Stfa2

0.940

Stfa3

0.890

Ctsb

0.861

Casp1

0.796

Csta2

0.776

Stfa1

0.776

Csta1

0.763

Cstdc5

0.760

Cstdc4

0.755

Csta3

0.753

Your Current Organism:

Mus musculus

NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Casp1	Csta1	ENSMUSP00000027015	ENSMUSP00000093795	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis (By similarity). Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically [...]	Cystatin-A; This is an intracellular thiol proteinase inhibitor. Belongs to the cystatin family.	0.797
Casp1	Csta2	ENSMUSP00000027015	ENSMUSP00000140745	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis (By similarity). Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically [...]	Cystatin A family member 2; Belongs to the cystatin family.	0.791
Casp1	Csta3	ENSMUSP00000027015	ENSMUSP00000087054	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis (By similarity). Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically [...]	Cystatin A family member 3.	0.794
Casp1	Cstdc4	ENSMUSP00000027015	ENSMUSP00000110508	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis (By similarity). Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically [...]	Cystatin domain-containing 4; Belongs to the cystatin family.	0.791
Casp1	Cstdc5	ENSMUSP00000027015	ENSMUSP00000093794	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis (By similarity). Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically [...]	Cystatin domain-containing 5.	0.720
Casp1	Ctsb	ENSMUSP00000027015	ENSMUSP00000006235	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis (By similarity). Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically [...]	Cathepsin B heavy chain; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins (By similarity). Cleaves matrix extracellular phosphoglycoprotein MEPE (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen. Has also been implicated in tumor invasion and metastasis (By similarity). Belongs to the peptidase C1 family.	0.948
Casp1	Stfa1	ENSMUSP00000027015	ENSMUSP00000156337	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis (By similarity). Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically [...]	Stefin-1; This is an intracellular thiol proteinase inhibitor; Belongs to the cystatin family.	0.720
Casp1	Stfa2	ENSMUSP00000027015	ENSMUSP00000023619	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis (By similarity). Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically [...]	Cystatin-A/B.	0.796
Casp1	Stfa2l1	ENSMUSP00000027015	ENSMUSP00000078181	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis (By similarity). Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically [...]	Stefin-2; This is an intracellular thiol proteinase inhibitor.	0.796
Casp1	Stfa3	ENSMUSP00000027015	ENSMUSP00000067445	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis (By similarity). Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically [...]	Stefin-3; This is an intracellular thiol proteinase inhibitor; Belongs to the cystatin family.	0.720
Csta1	Casp1	ENSMUSP00000093795	ENSMUSP00000027015	Cystatin-A; This is an intracellular thiol proteinase inhibitor. Belongs to the cystatin family.	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis (By similarity). Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically [...]	0.797
Csta1	Csta2	ENSMUSP00000093795	ENSMUSP00000140745	Cystatin-A; This is an intracellular thiol proteinase inhibitor. Belongs to the cystatin family.	Cystatin A family member 2; Belongs to the cystatin family.	0.729
Csta1	Csta3	ENSMUSP00000093795	ENSMUSP00000087054	Cystatin-A; This is an intracellular thiol proteinase inhibitor. Belongs to the cystatin family.	Cystatin A family member 3.	0.727
Csta1	Cstdc4	ENSMUSP00000093795	ENSMUSP00000110508	Cystatin-A; This is an intracellular thiol proteinase inhibitor. Belongs to the cystatin family.	Cystatin domain-containing 4; Belongs to the cystatin family.	0.726
Csta1	Cstdc5	ENSMUSP00000093795	ENSMUSP00000093794	Cystatin-A; This is an intracellular thiol proteinase inhibitor. Belongs to the cystatin family.	Cystatin domain-containing 5.	0.743
Csta1	Ctsb	ENSMUSP00000093795	ENSMUSP00000006235	Cystatin-A; This is an intracellular thiol proteinase inhibitor. Belongs to the cystatin family.	Cathepsin B heavy chain; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins (By similarity). Cleaves matrix extracellular phosphoglycoprotein MEPE (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen. Has also been implicated in tumor invasion and metastasis (By similarity). Belongs to the peptidase C1 family.	0.937
Csta1	Stfa1	ENSMUSP00000093795	ENSMUSP00000156337	Cystatin-A; This is an intracellular thiol proteinase inhibitor. Belongs to the cystatin family.	Stefin-1; This is an intracellular thiol proteinase inhibitor; Belongs to the cystatin family.	0.741
Csta1	Stfa2	ENSMUSP00000093795	ENSMUSP00000023619	Cystatin-A; This is an intracellular thiol proteinase inhibitor. Belongs to the cystatin family.	Cystatin-A/B.	0.730
Csta1	Stfa2l1	ENSMUSP00000093795	ENSMUSP00000078181	Cystatin-A; This is an intracellular thiol proteinase inhibitor. Belongs to the cystatin family.	Stefin-2; This is an intracellular thiol proteinase inhibitor.	0.763
Csta1	Stfa3	ENSMUSP00000093795	ENSMUSP00000067445	Cystatin-A; This is an intracellular thiol proteinase inhibitor. Belongs to the cystatin family.	Stefin-3; This is an intracellular thiol proteinase inhibitor; Belongs to the cystatin family.	0.804