node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AU041133 | Zfp119a | ENSMUSP00000144661 | ENSMUSP00000078587 | Expressed sequence AU041133. | KRAB zinc finger protein. | 0.683 |
Mrps9 | Zfp119a | ENSMUSP00000056855 | ENSMUSP00000078587 | 28S ribosomal protein S9, mitochondrial; Belongs to the universal ribosomal protein uS9 family. | KRAB zinc finger protein. | 0.432 |
Setdb1 | Trim28 | ENSMUSP00000015841 | ENSMUSP00000005705 | Histone-lysine N-methyltransferase SETDB1; Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys- 9' trimethylation is coordinated with DNA methylation. Probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' [...] | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.996 |
Setdb1 | Zfp119a | ENSMUSP00000015841 | ENSMUSP00000078587 | Histone-lysine N-methyltransferase SETDB1; Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys- 9' trimethylation is coordinated with DNA methylation. Probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' [...] | KRAB zinc finger protein. | 0.490 |
Trim28 | Setdb1 | ENSMUSP00000005705 | ENSMUSP00000015841 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Histone-lysine N-methyltransferase SETDB1; Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys- 9' trimethylation is coordinated with DNA methylation. Probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' [...] | 0.996 |
Trim28 | Zfp119a | ENSMUSP00000005705 | ENSMUSP00000078587 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | KRAB zinc finger protein. | 0.624 |
Trim28 | Zfp758 | ENSMUSP00000005705 | ENSMUSP00000121288 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 758. | 0.513 |
Zfp119a | AU041133 | ENSMUSP00000078587 | ENSMUSP00000144661 | KRAB zinc finger protein. | Expressed sequence AU041133. | 0.683 |
Zfp119a | Mrps9 | ENSMUSP00000078587 | ENSMUSP00000056855 | KRAB zinc finger protein. | 28S ribosomal protein S9, mitochondrial; Belongs to the universal ribosomal protein uS9 family. | 0.432 |
Zfp119a | Setdb1 | ENSMUSP00000078587 | ENSMUSP00000015841 | KRAB zinc finger protein. | Histone-lysine N-methyltransferase SETDB1; Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys- 9' trimethylation is coordinated with DNA methylation. Probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' [...] | 0.490 |
Zfp119a | Trim28 | ENSMUSP00000078587 | ENSMUSP00000005705 | KRAB zinc finger protein. | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.624 |
Zfp119a | Zfp119b | ENSMUSP00000078587 | ENSMUSP00000058300 | KRAB zinc finger protein. | Zinc finger protein 119b. | 0.687 |
Zfp119a | Zfp51 | ENSMUSP00000078587 | ENSMUSP00000045684 | KRAB zinc finger protein. | Zinc finger protein 51. | 0.433 |
Zfp119a | Zfp758 | ENSMUSP00000078587 | ENSMUSP00000121288 | KRAB zinc finger protein. | Zinc finger protein 758. | 0.489 |
Zfp119b | Zfp119a | ENSMUSP00000058300 | ENSMUSP00000078587 | Zinc finger protein 119b. | KRAB zinc finger protein. | 0.687 |
Zfp119b | Zfp51 | ENSMUSP00000058300 | ENSMUSP00000045684 | Zinc finger protein 119b. | Zinc finger protein 51. | 0.576 |
Zfp51 | Zfp119a | ENSMUSP00000045684 | ENSMUSP00000078587 | Zinc finger protein 51. | KRAB zinc finger protein. | 0.433 |
Zfp51 | Zfp119b | ENSMUSP00000045684 | ENSMUSP00000058300 | Zinc finger protein 51. | Zinc finger protein 119b. | 0.576 |
Zfp51 | Zfp758 | ENSMUSP00000045684 | ENSMUSP00000121288 | Zinc finger protein 51. | Zinc finger protein 758. | 0.534 |
Zfp758 | Trim28 | ENSMUSP00000121288 | ENSMUSP00000005705 | Zinc finger protein 758. | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.513 |