node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
2210010C04Rik | Cel | ENSMUSP00000031931 | ENSMUSP00000028161 | RIKEN cDNA 2210010C04 gene; Belongs to the peptidase S1 family. | Bile salt-activated lipase; Catalyzes the hydrolysis of a wide range of substrates including cholesteryl esters, phospholipids, lysophospholipids, di- and tri-acylglycerols, and fatty acid esters of hydroxy fatty acids (FAHFAs). Preferentially hydrolyzes FAHFAs with the ester bond further away from the carboxylate. Unsaturated FAHFAs are hydrolyzed more quickly than saturated FAHFAs. Has an essential role in the complete digestion of dietary lipids and their intestinal absorption, along with the absorption of fat-soluble vitamins (By similarity). | 0.978 |
2210010C04Rik | Cela2a | ENSMUSP00000031931 | ENSMUSP00000099539 | RIKEN cDNA 2210010C04 gene; Belongs to the peptidase S1 family. | Chymotrypsin-like elastase family member 2A; Acts upon elastin; Belongs to the peptidase S1 family. Elastase subfamily. | 0.838 |
2210010C04Rik | Cela3b | ENSMUSP00000031931 | ENSMUSP00000099581 | RIKEN cDNA 2210010C04 gene; Belongs to the peptidase S1 family. | Chymotrypsin-like elastase family member 3B; Efficient protease with alanine specificity but only little elastolytic activity; Belongs to the peptidase S1 family. Elastase subfamily. | 0.955 |
2210010C04Rik | Clps | ENSMUSP00000031931 | ENSMUSP00000025062 | RIKEN cDNA 2210010C04 gene; Belongs to the peptidase S1 family. | Colipase; Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase. | 0.740 |
2210010C04Rik | Cpa1 | ENSMUSP00000031931 | ENSMUSP00000031806 | RIKEN cDNA 2210010C04 gene; Belongs to the peptidase S1 family. | Carboxypeptidase A1; Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro. | 0.987 |
2210010C04Rik | Pnliprp1 | ENSMUSP00000031931 | ENSMUSP00000045465 | RIKEN cDNA 2210010C04 gene; Belongs to the peptidase S1 family. | Inactive pancreatic lipase-related protein 1; May function as inhibitor of dietary triglyceride digestion. Lacks detectable lipase activity (in vitro) (By similarity). | 0.751 |
2210010C04Rik | Prss2 | ENSMUSP00000031931 | ENSMUSP00000065393 | RIKEN cDNA 2210010C04 gene; Belongs to the peptidase S1 family. | Anionic trypsin-2. | 0.967 |
2210010C04Rik | Rnase1 | ENSMUSP00000031931 | ENSMUSP00000079025 | RIKEN cDNA 2210010C04 gene; Belongs to the peptidase S1 family. | Ribonuclease pancreatic; Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single-stranded and double- stranded RNA (By similarity); Belongs to the pancreatic ribonuclease family. | 0.699 |
2210010C04Rik | Sycn | ENSMUSP00000031931 | ENSMUSP00000112770 | RIKEN cDNA 2210010C04 gene; Belongs to the peptidase S1 family. | Syncollin; Functions in exocytosis in pancreatic acinar cells regulating the fusion of zymogen granules with each other. May have a pore-forming activity on membranes and regulate exocytosis in other exocrine tissues. | 0.762 |
Cel | 2210010C04Rik | ENSMUSP00000028161 | ENSMUSP00000031931 | Bile salt-activated lipase; Catalyzes the hydrolysis of a wide range of substrates including cholesteryl esters, phospholipids, lysophospholipids, di- and tri-acylglycerols, and fatty acid esters of hydroxy fatty acids (FAHFAs). Preferentially hydrolyzes FAHFAs with the ester bond further away from the carboxylate. Unsaturated FAHFAs are hydrolyzed more quickly than saturated FAHFAs. Has an essential role in the complete digestion of dietary lipids and their intestinal absorption, along with the absorption of fat-soluble vitamins (By similarity). | RIKEN cDNA 2210010C04 gene; Belongs to the peptidase S1 family. | 0.978 |
Cel | Cela2a | ENSMUSP00000028161 | ENSMUSP00000099539 | Bile salt-activated lipase; Catalyzes the hydrolysis of a wide range of substrates including cholesteryl esters, phospholipids, lysophospholipids, di- and tri-acylglycerols, and fatty acid esters of hydroxy fatty acids (FAHFAs). Preferentially hydrolyzes FAHFAs with the ester bond further away from the carboxylate. Unsaturated FAHFAs are hydrolyzed more quickly than saturated FAHFAs. Has an essential role in the complete digestion of dietary lipids and their intestinal absorption, along with the absorption of fat-soluble vitamins (By similarity). | Chymotrypsin-like elastase family member 2A; Acts upon elastin; Belongs to the peptidase S1 family. Elastase subfamily. | 0.968 |
Cel | Cela3b | ENSMUSP00000028161 | ENSMUSP00000099581 | Bile salt-activated lipase; Catalyzes the hydrolysis of a wide range of substrates including cholesteryl esters, phospholipids, lysophospholipids, di- and tri-acylglycerols, and fatty acid esters of hydroxy fatty acids (FAHFAs). Preferentially hydrolyzes FAHFAs with the ester bond further away from the carboxylate. Unsaturated FAHFAs are hydrolyzed more quickly than saturated FAHFAs. Has an essential role in the complete digestion of dietary lipids and their intestinal absorption, along with the absorption of fat-soluble vitamins (By similarity). | Chymotrypsin-like elastase family member 3B; Efficient protease with alanine specificity but only little elastolytic activity; Belongs to the peptidase S1 family. Elastase subfamily. | 0.984 |
Cel | Clps | ENSMUSP00000028161 | ENSMUSP00000025062 | Bile salt-activated lipase; Catalyzes the hydrolysis of a wide range of substrates including cholesteryl esters, phospholipids, lysophospholipids, di- and tri-acylglycerols, and fatty acid esters of hydroxy fatty acids (FAHFAs). Preferentially hydrolyzes FAHFAs with the ester bond further away from the carboxylate. Unsaturated FAHFAs are hydrolyzed more quickly than saturated FAHFAs. Has an essential role in the complete digestion of dietary lipids and their intestinal absorption, along with the absorption of fat-soluble vitamins (By similarity). | Colipase; Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase. | 0.943 |
Cel | Cpa1 | ENSMUSP00000028161 | ENSMUSP00000031806 | Bile salt-activated lipase; Catalyzes the hydrolysis of a wide range of substrates including cholesteryl esters, phospholipids, lysophospholipids, di- and tri-acylglycerols, and fatty acid esters of hydroxy fatty acids (FAHFAs). Preferentially hydrolyzes FAHFAs with the ester bond further away from the carboxylate. Unsaturated FAHFAs are hydrolyzed more quickly than saturated FAHFAs. Has an essential role in the complete digestion of dietary lipids and their intestinal absorption, along with the absorption of fat-soluble vitamins (By similarity). | Carboxypeptidase A1; Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro. | 0.986 |
Cel | Pnliprp1 | ENSMUSP00000028161 | ENSMUSP00000045465 | Bile salt-activated lipase; Catalyzes the hydrolysis of a wide range of substrates including cholesteryl esters, phospholipids, lysophospholipids, di- and tri-acylglycerols, and fatty acid esters of hydroxy fatty acids (FAHFAs). Preferentially hydrolyzes FAHFAs with the ester bond further away from the carboxylate. Unsaturated FAHFAs are hydrolyzed more quickly than saturated FAHFAs. Has an essential role in the complete digestion of dietary lipids and their intestinal absorption, along with the absorption of fat-soluble vitamins (By similarity). | Inactive pancreatic lipase-related protein 1; May function as inhibitor of dietary triglyceride digestion. Lacks detectable lipase activity (in vitro) (By similarity). | 0.990 |
Cel | Prss2 | ENSMUSP00000028161 | ENSMUSP00000065393 | Bile salt-activated lipase; Catalyzes the hydrolysis of a wide range of substrates including cholesteryl esters, phospholipids, lysophospholipids, di- and tri-acylglycerols, and fatty acid esters of hydroxy fatty acids (FAHFAs). Preferentially hydrolyzes FAHFAs with the ester bond further away from the carboxylate. Unsaturated FAHFAs are hydrolyzed more quickly than saturated FAHFAs. Has an essential role in the complete digestion of dietary lipids and their intestinal absorption, along with the absorption of fat-soluble vitamins (By similarity). | Anionic trypsin-2. | 0.972 |
Cel | Rnase1 | ENSMUSP00000028161 | ENSMUSP00000079025 | Bile salt-activated lipase; Catalyzes the hydrolysis of a wide range of substrates including cholesteryl esters, phospholipids, lysophospholipids, di- and tri-acylglycerols, and fatty acid esters of hydroxy fatty acids (FAHFAs). Preferentially hydrolyzes FAHFAs with the ester bond further away from the carboxylate. Unsaturated FAHFAs are hydrolyzed more quickly than saturated FAHFAs. Has an essential role in the complete digestion of dietary lipids and their intestinal absorption, along with the absorption of fat-soluble vitamins (By similarity). | Ribonuclease pancreatic; Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single-stranded and double- stranded RNA (By similarity); Belongs to the pancreatic ribonuclease family. | 0.735 |
Cel | Sycn | ENSMUSP00000028161 | ENSMUSP00000112770 | Bile salt-activated lipase; Catalyzes the hydrolysis of a wide range of substrates including cholesteryl esters, phospholipids, lysophospholipids, di- and tri-acylglycerols, and fatty acid esters of hydroxy fatty acids (FAHFAs). Preferentially hydrolyzes FAHFAs with the ester bond further away from the carboxylate. Unsaturated FAHFAs are hydrolyzed more quickly than saturated FAHFAs. Has an essential role in the complete digestion of dietary lipids and their intestinal absorption, along with the absorption of fat-soluble vitamins (By similarity). | Syncollin; Functions in exocytosis in pancreatic acinar cells regulating the fusion of zymogen granules with each other. May have a pore-forming activity on membranes and regulate exocytosis in other exocrine tissues. | 0.766 |
Cela2a | 2210010C04Rik | ENSMUSP00000099539 | ENSMUSP00000031931 | Chymotrypsin-like elastase family member 2A; Acts upon elastin; Belongs to the peptidase S1 family. Elastase subfamily. | RIKEN cDNA 2210010C04 gene; Belongs to the peptidase S1 family. | 0.838 |
Cela2a | Cel | ENSMUSP00000099539 | ENSMUSP00000028161 | Chymotrypsin-like elastase family member 2A; Acts upon elastin; Belongs to the peptidase S1 family. Elastase subfamily. | Bile salt-activated lipase; Catalyzes the hydrolysis of a wide range of substrates including cholesteryl esters, phospholipids, lysophospholipids, di- and tri-acylglycerols, and fatty acid esters of hydroxy fatty acids (FAHFAs). Preferentially hydrolyzes FAHFAs with the ester bond further away from the carboxylate. Unsaturated FAHFAs are hydrolyzed more quickly than saturated FAHFAs. Has an essential role in the complete digestion of dietary lipids and their intestinal absorption, along with the absorption of fat-soluble vitamins (By similarity). | 0.968 |