Lypd3 protein (mouse) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Mus musculus

NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Agr2	Lypd3	ENSMUSP00000020898	ENSMUSP00000079543	Anterior gradient protein 2 homolog; Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells. Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth (By similarity). Promotes cell adhesion (By similarity); Belongs to the AGR family.	Ly6/PLAUR domain-containing protein 3; Supports cell migration. May be involved in tumor progression (By similarity).	0.875
Galnt10	Lypd3	ENSMUSP00000065096	ENSMUSP00000079543	Polypeptide N-acetylgalactosaminyltransferase 10; Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward Muc5Ac and EA2 peptide substrates (By similarity).	Ly6/PLAUR domain-containing protein 3; Supports cell migration. May be involved in tumor progression (By similarity).	0.614
Gpr87	Krt5	ENSMUSP00000143683	ENSMUSP00000023709	G-protein coupled receptor 87; Receptor for lysophosphatidic acid (LPA). Necessary for p53/TP53-dependent survival in response to DNA damage (By similarity).	Keratin, type II cytoskeletal 5.	0.442
Gpr87	Lypd3	ENSMUSP00000143683	ENSMUSP00000079543	G-protein coupled receptor 87; Receptor for lysophosphatidic acid (LPA). Necessary for p53/TP53-dependent survival in response to DNA damage (By similarity).	Ly6/PLAUR domain-containing protein 3; Supports cell migration. May be involved in tumor progression (By similarity).	0.628
Krt13	Krt14	ENSMUSP00000007275	ENSMUSP00000007272	Keratin, type I cytoskeletal 13.	Keratin, type I cytoskeletal 14; The nonhelical tail domain is involved in promoting KRT5- KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro.	0.960
Krt13	Krt15	ENSMUSP00000007275	ENSMUSP00000103034	Keratin, type I cytoskeletal 13.	Keratin, type I cytoskeletal 15; In the absence of KRT14, makes a bona fide, but ultrastructurally distinct keratin filament network with KRT5. Belongs to the intermediate filament family.	0.968
Krt13	Krt5	ENSMUSP00000007275	ENSMUSP00000023709	Keratin, type I cytoskeletal 13.	Keratin, type II cytoskeletal 5.	0.671
Krt13	Lypd3	ENSMUSP00000007275	ENSMUSP00000079543	Keratin, type I cytoskeletal 13.	Ly6/PLAUR domain-containing protein 3; Supports cell migration. May be involved in tumor progression (By similarity).	0.569
Krt14	Krt13	ENSMUSP00000007272	ENSMUSP00000007275	Keratin, type I cytoskeletal 14; The nonhelical tail domain is involved in promoting KRT5- KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro.	Keratin, type I cytoskeletal 13.	0.960
Krt14	Krt15	ENSMUSP00000007272	ENSMUSP00000103034	Keratin, type I cytoskeletal 14; The nonhelical tail domain is involved in promoting KRT5- KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro.	Keratin, type I cytoskeletal 15; In the absence of KRT14, makes a bona fide, but ultrastructurally distinct keratin filament network with KRT5. Belongs to the intermediate filament family.	0.975
Krt14	Krt5	ENSMUSP00000007272	ENSMUSP00000023709	Keratin, type I cytoskeletal 14; The nonhelical tail domain is involved in promoting KRT5- KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro.	Keratin, type II cytoskeletal 5.	0.997
Krt14	Lypd3	ENSMUSP00000007272	ENSMUSP00000079543	Keratin, type I cytoskeletal 14; The nonhelical tail domain is involved in promoting KRT5- KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro.	Ly6/PLAUR domain-containing protein 3; Supports cell migration. May be involved in tumor progression (By similarity).	0.600
Krt14	Psapl1	ENSMUSP00000007272	ENSMUSP00000100594	Keratin, type I cytoskeletal 14; The nonhelical tail domain is involved in promoting KRT5- KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro.	Proactivator polypeptide-like 1; May activate the lysosomal degradation of sphingolipids.	0.446
Krt15	Krt13	ENSMUSP00000103034	ENSMUSP00000007275	Keratin, type I cytoskeletal 15; In the absence of KRT14, makes a bona fide, but ultrastructurally distinct keratin filament network with KRT5. Belongs to the intermediate filament family.	Keratin, type I cytoskeletal 13.	0.968
Krt15	Krt14	ENSMUSP00000103034	ENSMUSP00000007272	Keratin, type I cytoskeletal 15; In the absence of KRT14, makes a bona fide, but ultrastructurally distinct keratin filament network with KRT5. Belongs to the intermediate filament family.	Keratin, type I cytoskeletal 14; The nonhelical tail domain is involved in promoting KRT5- KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro.	0.975
Krt15	Krt5	ENSMUSP00000103034	ENSMUSP00000023709	Keratin, type I cytoskeletal 15; In the absence of KRT14, makes a bona fide, but ultrastructurally distinct keratin filament network with KRT5. Belongs to the intermediate filament family.	Keratin, type II cytoskeletal 5.	0.843
Krt15	Lypd3	ENSMUSP00000103034	ENSMUSP00000079543	Keratin, type I cytoskeletal 15; In the absence of KRT14, makes a bona fide, but ultrastructurally distinct keratin filament network with KRT5. Belongs to the intermediate filament family.	Ly6/PLAUR domain-containing protein 3; Supports cell migration. May be involved in tumor progression (By similarity).	0.560
Krt5	Gpr87	ENSMUSP00000023709	ENSMUSP00000143683	Keratin, type II cytoskeletal 5.	G-protein coupled receptor 87; Receptor for lysophosphatidic acid (LPA). Necessary for p53/TP53-dependent survival in response to DNA damage (By similarity).	0.442
Krt5	Krt13	ENSMUSP00000023709	ENSMUSP00000007275	Keratin, type II cytoskeletal 5.	Keratin, type I cytoskeletal 13.	0.671
Krt5	Krt14	ENSMUSP00000023709	ENSMUSP00000007272	Keratin, type II cytoskeletal 5.	Keratin, type I cytoskeletal 14; The nonhelical tail domain is involved in promoting KRT5- KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro.	0.997