node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Akap3 | Oaz3 | ENSMUSP00000093091 | ENSMUSP00000143080 | A-kinase anchor protein 3; May function as a regulator of both motility- and head- associated functions such as capacitation and the acrosome reaction. Belongs to the AKAP110 family. | Ornithine decarboxylase antizyme 3; Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimers. Does not target the ODC monomers for degradation, which allows a protein synthesis-independent restoration of ODC activity. Stabilizes AZIN2 by interfering with its ubiquitination. Involved in the translocation of AZNI2 from ER-Golgi intermediate compartment (ERGIC) to the cytoso [...] | 0.471 |
Akap3 | Odf1 | ENSMUSP00000093091 | ENSMUSP00000080632 | A-kinase anchor protein 3; May function as a regulator of both motility- and head- associated functions such as capacitation and the acrosome reaction. Belongs to the AKAP110 family. | Outer dense fiber protein 1; Component of the outer dense fibers (ODF) of spermatozoa. ODF are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail. | 0.808 |
Akap3 | Spata19 | ENSMUSP00000093091 | ENSMUSP00000034473 | A-kinase anchor protein 3; May function as a regulator of both motility- and head- associated functions such as capacitation and the acrosome reaction. Belongs to the AKAP110 family. | Spermatogenesis-associated protein 19, mitochondrial; May have a role in spermiogenesis. | 0.427 |
Akap3 | Sun5 | ENSMUSP00000093091 | ENSMUSP00000028982 | A-kinase anchor protein 3; May function as a regulator of both motility- and head- associated functions such as capacitation and the acrosome reaction. Belongs to the AKAP110 family. | SUN domain-containing protein 5; Plays an essential role in anchoring sperm head to the tail. Is responsible for the attachment of the coupling apparatus to the sperm nuclear envelope. | 0.401 |
Akap3 | Tnp1 | ENSMUSP00000093091 | ENSMUSP00000027374 | A-kinase anchor protein 3; May function as a regulator of both motility- and head- associated functions such as capacitation and the acrosome reaction. Belongs to the AKAP110 family. | Spermatid nuclear transition protein 1; Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction. The histone H2AB1-H2BC1/TH2B dimer is required for loading of TNP1 onto chromatin. | 0.564 |
Akap4 | Oaz3 | ENSMUSP00000050962 | ENSMUSP00000143080 | A-kinase anchor protein 4; Major structural component of sperm fibrous sheath. Plays a role in sperm motility. | Ornithine decarboxylase antizyme 3; Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimers. Does not target the ODC monomers for degradation, which allows a protein synthesis-independent restoration of ODC activity. Stabilizes AZIN2 by interfering with its ubiquitination. Involved in the translocation of AZNI2 from ER-Golgi intermediate compartment (ERGIC) to the cytoso [...] | 0.465 |
Akap4 | Odf1 | ENSMUSP00000050962 | ENSMUSP00000080632 | A-kinase anchor protein 4; Major structural component of sperm fibrous sheath. Plays a role in sperm motility. | Outer dense fiber protein 1; Component of the outer dense fibers (ODF) of spermatozoa. ODF are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail. | 0.743 |
Akap4 | Smcp | ENSMUSP00000050962 | ENSMUSP00000096487 | A-kinase anchor protein 4; Major structural component of sperm fibrous sheath. Plays a role in sperm motility. | Sperm mitochondrial-associated cysteine-rich protein; Involved in sperm motility. Its absence is associated with genetic background dependent male infertility. Infertility may be due to reduced sperm motility in the female reproductive tract and inability to penetrate the oocyte zona pellucida. | 0.448 |
Akap4 | Spata19 | ENSMUSP00000050962 | ENSMUSP00000034473 | A-kinase anchor protein 4; Major structural component of sperm fibrous sheath. Plays a role in sperm motility. | Spermatogenesis-associated protein 19, mitochondrial; May have a role in spermiogenesis. | 0.498 |
Akap4 | Sun5 | ENSMUSP00000050962 | ENSMUSP00000028982 | A-kinase anchor protein 4; Major structural component of sperm fibrous sheath. Plays a role in sperm motility. | SUN domain-containing protein 5; Plays an essential role in anchoring sperm head to the tail. Is responsible for the attachment of the coupling apparatus to the sperm nuclear envelope. | 0.402 |
Akap4 | Tnp1 | ENSMUSP00000050962 | ENSMUSP00000027374 | A-kinase anchor protein 4; Major structural component of sperm fibrous sheath. Plays a role in sperm motility. | Spermatid nuclear transition protein 1; Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction. The histone H2AB1-H2BC1/TH2B dimer is required for loading of TNP1 onto chromatin. | 0.720 |
Ccdc42 | Oaz3 | ENSMUSP00000114381 | ENSMUSP00000143080 | Coiled-coil domain-containing protein 42; Required for sperm development. Belongs to the CFAP73 family. | Ornithine decarboxylase antizyme 3; Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimers. Does not target the ODC monomers for degradation, which allows a protein synthesis-independent restoration of ODC activity. Stabilizes AZIN2 by interfering with its ubiquitination. Involved in the translocation of AZNI2 from ER-Golgi intermediate compartment (ERGIC) to the cytoso [...] | 0.539 |
Ccdc42 | Odf1 | ENSMUSP00000114381 | ENSMUSP00000080632 | Coiled-coil domain-containing protein 42; Required for sperm development. Belongs to the CFAP73 family. | Outer dense fiber protein 1; Component of the outer dense fibers (ODF) of spermatozoa. ODF are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail. | 0.757 |
Ccdc42 | Spag4 | ENSMUSP00000114381 | ENSMUSP00000036484 | Coiled-coil domain-containing protein 42; Required for sperm development. Belongs to the CFAP73 family. | Sperm-associated antigen 4 protein; Involved in spermatogenesis. Required for sperm head formation but not required to establish and maintain general polarity of the sperm head. Required for anchoring and organization of the manchette. Required for targeting of SUN3 and probably SYNE1 through a probable SUN1:SYNE3 LINC complex to the nuclear envelope and involved in accurate posterior sperm head localization of the complex. May anchor SUN3 the nuclear envelope. Involved in maintenance of the nuclear envelope integrity. May assist the organization and assembly of outer dense fibers (ODF [...] | 0.466 |
Ccdc42 | Spata6 | ENSMUSP00000114381 | ENSMUSP00000036964 | Coiled-coil domain-containing protein 42; Required for sperm development. Belongs to the CFAP73 family. | Spermatogenesis-associated protein 6; Required for formation of the sperm connecting piece during spermiogenesis. Sperm connecting piece is essential for linking the developing flagellum to the head during late spermiogenesis. May be involved in myosin-based microfilament transport through interaction with myosin subunits. | 0.425 |
Ccdc42 | Sun5 | ENSMUSP00000114381 | ENSMUSP00000028982 | Coiled-coil domain-containing protein 42; Required for sperm development. Belongs to the CFAP73 family. | SUN domain-containing protein 5; Plays an essential role in anchoring sperm head to the tail. Is responsible for the attachment of the coupling apparatus to the sperm nuclear envelope. | 0.617 |
Oaz3 | Akap3 | ENSMUSP00000143080 | ENSMUSP00000093091 | Ornithine decarboxylase antizyme 3; Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimers. Does not target the ODC monomers for degradation, which allows a protein synthesis-independent restoration of ODC activity. Stabilizes AZIN2 by interfering with its ubiquitination. Involved in the translocation of AZNI2 from ER-Golgi intermediate compartment (ERGIC) to the cytoso [...] | A-kinase anchor protein 3; May function as a regulator of both motility- and head- associated functions such as capacitation and the acrosome reaction. Belongs to the AKAP110 family. | 0.471 |
Oaz3 | Akap4 | ENSMUSP00000143080 | ENSMUSP00000050962 | Ornithine decarboxylase antizyme 3; Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimers. Does not target the ODC monomers for degradation, which allows a protein synthesis-independent restoration of ODC activity. Stabilizes AZIN2 by interfering with its ubiquitination. Involved in the translocation of AZNI2 from ER-Golgi intermediate compartment (ERGIC) to the cytoso [...] | A-kinase anchor protein 4; Major structural component of sperm fibrous sheath. Plays a role in sperm motility. | 0.465 |
Oaz3 | Ccdc42 | ENSMUSP00000143080 | ENSMUSP00000114381 | Ornithine decarboxylase antizyme 3; Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimers. Does not target the ODC monomers for degradation, which allows a protein synthesis-independent restoration of ODC activity. Stabilizes AZIN2 by interfering with its ubiquitination. Involved in the translocation of AZNI2 from ER-Golgi intermediate compartment (ERGIC) to the cytoso [...] | Coiled-coil domain-containing protein 42; Required for sperm development. Belongs to the CFAP73 family. | 0.539 |
Oaz3 | Odf1 | ENSMUSP00000143080 | ENSMUSP00000080632 | Ornithine decarboxylase antizyme 3; Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimers. Does not target the ODC monomers for degradation, which allows a protein synthesis-independent restoration of ODC activity. Stabilizes AZIN2 by interfering with its ubiquitination. Involved in the translocation of AZNI2 from ER-Golgi intermediate compartment (ERGIC) to the cytoso [...] | Outer dense fiber protein 1; Component of the outer dense fibers (ODF) of spermatozoa. ODF are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail. | 0.835 |