| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Arg1 | Chil3 | ENSMUSP00000020161 | ENSMUSP00000053923 | Arginase-1; Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell proliferation, respectively; the urea cycle takes place primarily in the liver and, to a lesser extent, in the kidneys. | Chitinase-like protein 3; Lectin that binds saccharides with a free amino group, such as glucosamine or galactosamine. Binding to oligomeric saccharides is much stronger than binding to mono- or disaccharides. Also binds chitin and heparin. Has weak hexosaminidase activity but no chitinase activity. Has chemotactic activity for T-lymphocytes, bone marrow cells and eosinophils. May play a role in inflammation and allergy. | 0.873 |
| Arg1 | Chil4 | ENSMUSP00000020161 | ENSMUSP00000080851 | Arginase-1; Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell proliferation, respectively; the urea cycle takes place primarily in the liver and, to a lesser extent, in the kidneys. | Chitinase-like protein 4; Has low chemotactic activity for eosinophils. May play a role in inflammation and allergy. Has no chitinase activity. Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily. | 0.540 |
| Arg1 | Il13 | ENSMUSP00000020161 | ENSMUSP00000020650 | Arginase-1; Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell proliferation, respectively; the urea cycle takes place primarily in the liver and, to a lesser extent, in the kidneys. | Interleukin-13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses (By similarity). Positively regulates IL31RA expression in macrophages ; Belongs to the IL-4/IL-13 family. | 0.823 |
| Arg1 | Il4 | ENSMUSP00000020161 | ENSMUSP00000000889 | Arginase-1; Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell proliferation, respectively; the urea cycle takes place primarily in the liver and, to a lesser extent, in the kidneys. | Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4. Belongs to the IL- [...] | 0.870 |
| Arg1 | Retnla | ENSMUSP00000020161 | ENSMUSP00000023329 | Arginase-1; Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell proliferation, respectively; the urea cycle takes place primarily in the liver and, to a lesser extent, in the kidneys. | Resistin-like alpha; Probable hormone. Plays a role in pulmonary vascular remodeling; Belongs to the resistin/FIZZ family. | 0.845 |
| Chil3 | Arg1 | ENSMUSP00000053923 | ENSMUSP00000020161 | Chitinase-like protein 3; Lectin that binds saccharides with a free amino group, such as glucosamine or galactosamine. Binding to oligomeric saccharides is much stronger than binding to mono- or disaccharides. Also binds chitin and heparin. Has weak hexosaminidase activity but no chitinase activity. Has chemotactic activity for T-lymphocytes, bone marrow cells and eosinophils. May play a role in inflammation and allergy. | Arginase-1; Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell proliferation, respectively; the urea cycle takes place primarily in the liver and, to a lesser extent, in the kidneys. | 0.873 |
| Chil3 | Chil4 | ENSMUSP00000053923 | ENSMUSP00000080851 | Chitinase-like protein 3; Lectin that binds saccharides with a free amino group, such as glucosamine or galactosamine. Binding to oligomeric saccharides is much stronger than binding to mono- or disaccharides. Also binds chitin and heparin. Has weak hexosaminidase activity but no chitinase activity. Has chemotactic activity for T-lymphocytes, bone marrow cells and eosinophils. May play a role in inflammation and allergy. | Chitinase-like protein 4; Has low chemotactic activity for eosinophils. May play a role in inflammation and allergy. Has no chitinase activity. Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily. | 0.766 |
| Chil3 | Il13 | ENSMUSP00000053923 | ENSMUSP00000020650 | Chitinase-like protein 3; Lectin that binds saccharides with a free amino group, such as glucosamine or galactosamine. Binding to oligomeric saccharides is much stronger than binding to mono- or disaccharides. Also binds chitin and heparin. Has weak hexosaminidase activity but no chitinase activity. Has chemotactic activity for T-lymphocytes, bone marrow cells and eosinophils. May play a role in inflammation and allergy. | Interleukin-13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses (By similarity). Positively regulates IL31RA expression in macrophages ; Belongs to the IL-4/IL-13 family. | 0.749 |
| Chil3 | Il4 | ENSMUSP00000053923 | ENSMUSP00000000889 | Chitinase-like protein 3; Lectin that binds saccharides with a free amino group, such as glucosamine or galactosamine. Binding to oligomeric saccharides is much stronger than binding to mono- or disaccharides. Also binds chitin and heparin. Has weak hexosaminidase activity but no chitinase activity. Has chemotactic activity for T-lymphocytes, bone marrow cells and eosinophils. May play a role in inflammation and allergy. | Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4. Belongs to the IL- [...] | 0.791 |
| Chil3 | Retnla | ENSMUSP00000053923 | ENSMUSP00000023329 | Chitinase-like protein 3; Lectin that binds saccharides with a free amino group, such as glucosamine or galactosamine. Binding to oligomeric saccharides is much stronger than binding to mono- or disaccharides. Also binds chitin and heparin. Has weak hexosaminidase activity but no chitinase activity. Has chemotactic activity for T-lymphocytes, bone marrow cells and eosinophils. May play a role in inflammation and allergy. | Resistin-like alpha; Probable hormone. Plays a role in pulmonary vascular remodeling; Belongs to the resistin/FIZZ family. | 0.892 |
| Chil3 | Rnase2a | ENSMUSP00000053923 | ENSMUSP00000056418 | Chitinase-like protein 3; Lectin that binds saccharides with a free amino group, such as glucosamine or galactosamine. Binding to oligomeric saccharides is much stronger than binding to mono- or disaccharides. Also binds chitin and heparin. Has weak hexosaminidase activity but no chitinase activity. Has chemotactic activity for T-lymphocytes, bone marrow cells and eosinophils. May play a role in inflammation and allergy. | Ribonuclease, RNase A family, 2A (liver, eosinophil-derived neurotoxin); Belongs to the pancreatic ribonuclease family. | 0.467 |
| Chil3 | mt-Co2 | ENSMUSP00000053923 | ENSMUSP00000080994 | Chitinase-like protein 3; Lectin that binds saccharides with a free amino group, such as glucosamine or galactosamine. Binding to oligomeric saccharides is much stronger than binding to mono- or disaccharides. Also binds chitin and heparin. Has weak hexosaminidase activity but no chitinase activity. Has chemotactic activity for T-lymphocytes, bone marrow cells and eosinophils. May play a role in inflammation and allergy. | Cytochrome c oxidase subunit 2; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...] | 0.481 |
| Chil3 | mt-Co3 | ENSMUSP00000053923 | ENSMUSP00000080997 | Chitinase-like protein 3; Lectin that binds saccharides with a free amino group, such as glucosamine or galactosamine. Binding to oligomeric saccharides is much stronger than binding to mono- or disaccharides. Also binds chitin and heparin. Has weak hexosaminidase activity but no chitinase activity. Has chemotactic activity for T-lymphocytes, bone marrow cells and eosinophils. May play a role in inflammation and allergy. | Cytochrome c oxidase subunit 3; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...] | 0.489 |
| Chil4 | Arg1 | ENSMUSP00000080851 | ENSMUSP00000020161 | Chitinase-like protein 4; Has low chemotactic activity for eosinophils. May play a role in inflammation and allergy. Has no chitinase activity. Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily. | Arginase-1; Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell proliferation, respectively; the urea cycle takes place primarily in the liver and, to a lesser extent, in the kidneys. | 0.540 |
| Chil4 | Chil3 | ENSMUSP00000080851 | ENSMUSP00000053923 | Chitinase-like protein 4; Has low chemotactic activity for eosinophils. May play a role in inflammation and allergy. Has no chitinase activity. Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily. | Chitinase-like protein 3; Lectin that binds saccharides with a free amino group, such as glucosamine or galactosamine. Binding to oligomeric saccharides is much stronger than binding to mono- or disaccharides. Also binds chitin and heparin. Has weak hexosaminidase activity but no chitinase activity. Has chemotactic activity for T-lymphocytes, bone marrow cells and eosinophils. May play a role in inflammation and allergy. | 0.766 |
| Chil4 | Clca1 | ENSMUSP00000080851 | ENSMUSP00000029919 | Chitinase-like protein 4; Has low chemotactic activity for eosinophils. May play a role in inflammation and allergy. Has no chitinase activity. Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily. | Calcium-activated chloride channel regulator 1; May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC. Belongs to the CLCR family. | 0.546 |
| Chil4 | Il13 | ENSMUSP00000080851 | ENSMUSP00000020650 | Chitinase-like protein 4; Has low chemotactic activity for eosinophils. May play a role in inflammation and allergy. Has no chitinase activity. Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily. | Interleukin-13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses (By similarity). Positively regulates IL31RA expression in macrophages ; Belongs to the IL-4/IL-13 family. | 0.506 |
| Chil4 | Il4 | ENSMUSP00000080851 | ENSMUSP00000000889 | Chitinase-like protein 4; Has low chemotactic activity for eosinophils. May play a role in inflammation and allergy. Has no chitinase activity. Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily. | Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4. Belongs to the IL- [...] | 0.490 |
| Chil4 | Muc5ac | ENSMUSP00000080851 | ENSMUSP00000039699 | Chitinase-like protein 4; Has low chemotactic activity for eosinophils. May play a role in inflammation and allergy. Has no chitinase activity. Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily. | Mucin 5, subtypes A and C, tracheobronchial/gastric. | 0.468 |
| Chil4 | Retnla | ENSMUSP00000080851 | ENSMUSP00000023329 | Chitinase-like protein 4; Has low chemotactic activity for eosinophils. May play a role in inflammation and allergy. Has no chitinase activity. Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily. | Resistin-like alpha; Probable hormone. Plays a role in pulmonary vascular remodeling; Belongs to the resistin/FIZZ family. | 0.679 |
STRING v12.5 is now available!
