node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Insl3 | Insl5 | ENSMUSP00000034261 | ENSMUSP00000102482 | Insulin-like 3 A chain; Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor (By similarity). | Insulin-like peptide INSL5 A chain; May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high potency and appears to be the endogenous ligand for this receptor (By similarity); Belongs to the insulin family. | 0.968 |
Insl3 | Insl6 | ENSMUSP00000034261 | ENSMUSP00000054488 | Insulin-like 3 A chain; Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor (By similarity). | Insulin-like peptide INSL6 A chain; May have a role in sperm development and fertilization; Belongs to the insulin family. | 0.700 |
Insl3 | Rln1 | ENSMUSP00000034261 | ENSMUSP00000043376 | Insulin-like 3 A chain; Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor (By similarity). | Relaxin A chain; Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. | 0.977 |
Insl3 | Rln3 | ENSMUSP00000034261 | ENSMUSP00000051392 | Insulin-like 3 A chain; Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor (By similarity). | Relaxin-3 A chain; May play a role in neuropeptide signaling processes. Ligand for LGR7, relaxin-3 receptor-1 and relaxin-3 receptor-2 (By similarity); Belongs to the insulin family. | 0.974 |
Insl3 | Rxfp1 | ENSMUSP00000034261 | ENSMUSP00000077611 | Insulin-like 3 A chain; Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor (By similarity). | Relaxin receptor 1; Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP. | 0.995 |
Insl3 | Rxfp2 | ENSMUSP00000034261 | ENSMUSP00000067897 | Insulin-like 3 A chain; Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor (By similarity). | Relaxin receptor 2; Receptor for relaxin. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. May also be a receptor for Leydig insulin-like peptide (INSL3) (By similarity); Belongs to the G-protein coupled receptor 1 family. | 0.999 |
Insl3 | Rxfp3 | ENSMUSP00000034261 | ENSMUSP00000062741 | Insulin-like 3 A chain; Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor (By similarity). | Relaxin-3 receptor 1; Receptor for RNL3/relaxin-3. Binding of the ligand inhibit cAMP accumulation (By similarity); Belongs to the G-protein coupled receptor 1 family. | 0.977 |
Insl3 | Rxfp4 | ENSMUSP00000034261 | ENSMUSP00000058732 | Insulin-like 3 A chain; Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor (By similarity). | Relaxin-3 receptor 2; High affinity receptor for INSL5. Also acts as receptor for RLN3/relaxin-3, as well as bradykinin and kallidin. Binding of the ligand inhibit cAMP accumulation (By similarity). | 0.970 |
Insl5 | Insl3 | ENSMUSP00000102482 | ENSMUSP00000034261 | Insulin-like peptide INSL5 A chain; May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high potency and appears to be the endogenous ligand for this receptor (By similarity); Belongs to the insulin family. | Insulin-like 3 A chain; Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor (By similarity). | 0.968 |
Insl5 | Insl6 | ENSMUSP00000102482 | ENSMUSP00000054488 | Insulin-like peptide INSL5 A chain; May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high potency and appears to be the endogenous ligand for this receptor (By similarity); Belongs to the insulin family. | Insulin-like peptide INSL6 A chain; May have a role in sperm development and fertilization; Belongs to the insulin family. | 0.751 |
Insl5 | Rln1 | ENSMUSP00000102482 | ENSMUSP00000043376 | Insulin-like peptide INSL5 A chain; May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high potency and appears to be the endogenous ligand for this receptor (By similarity); Belongs to the insulin family. | Relaxin A chain; Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. | 0.955 |
Insl5 | Rln3 | ENSMUSP00000102482 | ENSMUSP00000051392 | Insulin-like peptide INSL5 A chain; May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high potency and appears to be the endogenous ligand for this receptor (By similarity); Belongs to the insulin family. | Relaxin-3 A chain; May play a role in neuropeptide signaling processes. Ligand for LGR7, relaxin-3 receptor-1 and relaxin-3 receptor-2 (By similarity); Belongs to the insulin family. | 0.919 |
Insl5 | Rxfp1 | ENSMUSP00000102482 | ENSMUSP00000077611 | Insulin-like peptide INSL5 A chain; May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high potency and appears to be the endogenous ligand for this receptor (By similarity); Belongs to the insulin family. | Relaxin receptor 1; Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP. | 0.963 |
Insl5 | Rxfp2 | ENSMUSP00000102482 | ENSMUSP00000067897 | Insulin-like peptide INSL5 A chain; May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high potency and appears to be the endogenous ligand for this receptor (By similarity); Belongs to the insulin family. | Relaxin receptor 2; Receptor for relaxin. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. May also be a receptor for Leydig insulin-like peptide (INSL3) (By similarity); Belongs to the G-protein coupled receptor 1 family. | 0.960 |
Insl5 | Rxfp3 | ENSMUSP00000102482 | ENSMUSP00000062741 | Insulin-like peptide INSL5 A chain; May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high potency and appears to be the endogenous ligand for this receptor (By similarity); Belongs to the insulin family. | Relaxin-3 receptor 1; Receptor for RNL3/relaxin-3. Binding of the ligand inhibit cAMP accumulation (By similarity); Belongs to the G-protein coupled receptor 1 family. | 0.968 |
Insl5 | Rxfp4 | ENSMUSP00000102482 | ENSMUSP00000058732 | Insulin-like peptide INSL5 A chain; May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high potency and appears to be the endogenous ligand for this receptor (By similarity); Belongs to the insulin family. | Relaxin-3 receptor 2; High affinity receptor for INSL5. Also acts as receptor for RLN3/relaxin-3, as well as bradykinin and kallidin. Binding of the ligand inhibit cAMP accumulation (By similarity). | 0.990 |
Insl5 | Terf1 | ENSMUSP00000102482 | ENSMUSP00000140744 | Insulin-like peptide INSL5 A chain; May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high potency and appears to be the endogenous ligand for this receptor (By similarity); Belongs to the insulin family. | Telomeric repeat-binding factor 1; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. | 0.601 |
Insl5 | Tinf2 | ENSMUSP00000102482 | ENSMUSP00000007733 | Insulin-like peptide INSL5 A chain; May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high potency and appears to be the endogenous ligand for this receptor (By similarity); Belongs to the insulin family. | TERF1-interacting nuclear factor 2; Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Plays a role in shelterin complex assembly (By similarity). | 0.604 |
Insl6 | Insl3 | ENSMUSP00000054488 | ENSMUSP00000034261 | Insulin-like peptide INSL6 A chain; May have a role in sperm development and fertilization; Belongs to the insulin family. | Insulin-like 3 A chain; Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor (By similarity). | 0.700 |
Insl6 | Insl5 | ENSMUSP00000054488 | ENSMUSP00000102482 | Insulin-like peptide INSL6 A chain; May have a role in sperm development and fertilization; Belongs to the insulin family. | Insulin-like peptide INSL5 A chain; May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high potency and appears to be the endogenous ligand for this receptor (By similarity); Belongs to the insulin family. | 0.751 |