node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Bcas3 | Fhad1 | ENSMUSP00000074416 | ENSMUSP00000101406 | Breast carcinoma-amplified sequence 3 homolog; Functions synergistically with PELP1 as a transcriptional coactivator of estrogen receptor-responsive genes. Stimulates histone acetyltransferase activity. Binds to chromatin (By similarity). Plays a role in angiogenesis. Participates in the regulation of cell polarity and directional endothelial cell migration by mediating both the activation and recruitment of CDC42 and the reorganization of the actin cytoskeleton at the cell leading edge. Promotes filipodia formation. Belongs to the BCAS3 family. | Forkhead-associated domain-containing protein 1. | 0.580 |
Bcas3 | Sel1l3 | ENSMUSP00000074416 | ENSMUSP00000031090 | Breast carcinoma-amplified sequence 3 homolog; Functions synergistically with PELP1 as a transcriptional coactivator of estrogen receptor-responsive genes. Stimulates histone acetyltransferase activity. Binds to chromatin (By similarity). Plays a role in angiogenesis. Participates in the regulation of cell polarity and directional endothelial cell migration by mediating both the activation and recruitment of CDC42 and the reorganization of the actin cytoskeleton at the cell leading edge. Promotes filipodia formation. Belongs to the BCAS3 family. | Protein sel-1 homolog 3. | 0.496 |
Bcas3 | Susd4 | ENSMUSP00000074416 | ENSMUSP00000082873 | Breast carcinoma-amplified sequence 3 homolog; Functions synergistically with PELP1 as a transcriptional coactivator of estrogen receptor-responsive genes. Stimulates histone acetyltransferase activity. Binds to chromatin (By similarity). Plays a role in angiogenesis. Participates in the regulation of cell polarity and directional endothelial cell migration by mediating both the activation and recruitment of CDC42 and the reorganization of the actin cytoskeleton at the cell leading edge. Promotes filipodia formation. Belongs to the BCAS3 family. | Sushi domain-containing protein 4; Acts as complement inhibitor by disrupting the formation of the classical C3 convertase. Isoform 3 inhibits the classical complement pathway, while membrane-bound isoform 1 inhibits deposition of C3b via both the classical and alternative complement pathways. | 0.468 |
Bcas3 | Zfp407 | ENSMUSP00000074416 | ENSMUSP00000118361 | Breast carcinoma-amplified sequence 3 homolog; Functions synergistically with PELP1 as a transcriptional coactivator of estrogen receptor-responsive genes. Stimulates histone acetyltransferase activity. Binds to chromatin (By similarity). Plays a role in angiogenesis. Participates in the regulation of cell polarity and directional endothelial cell migration by mediating both the activation and recruitment of CDC42 and the reorganization of the actin cytoskeleton at the cell leading edge. Promotes filipodia formation. Belongs to the BCAS3 family. | Zinc finger protein 407. | 0.549 |
Dennd1b | Rhbdl2 | ENSMUSP00000127580 | ENSMUSP00000054546 | DENN domain-containing protein 1B; Guanine nucleotide exchange factor (GEF) for RAB35 that acts as a regulator of T-cell receptor (TCR) internalization in TH2 cells. Acts by promoting the exchange of GDP to GTP, converting inactive GDP- bound RAB35 into its active GTP-bound form. Plays a role in clathrin- mediated endocytosis. Controls cytokine production in TH2 lymphocytes by controlling the rate of TCR internalization and routing to endosomes: acts by mediating clathrin-mediated endocytosis of TCR via its interaction with the adapter protein complex 2 (AP-2) and GEF activity. Dysregu [...] | Rhomboid-related protein 2, C-terminal fragment; Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Known substrate: EFNB3 (By similarity); Belongs to the peptidase S54 family. | 0.483 |
Dennd1b | Susd4 | ENSMUSP00000127580 | ENSMUSP00000082873 | DENN domain-containing protein 1B; Guanine nucleotide exchange factor (GEF) for RAB35 that acts as a regulator of T-cell receptor (TCR) internalization in TH2 cells. Acts by promoting the exchange of GDP to GTP, converting inactive GDP- bound RAB35 into its active GTP-bound form. Plays a role in clathrin- mediated endocytosis. Controls cytokine production in TH2 lymphocytes by controlling the rate of TCR internalization and routing to endosomes: acts by mediating clathrin-mediated endocytosis of TCR via its interaction with the adapter protein complex 2 (AP-2) and GEF activity. Dysregu [...] | Sushi domain-containing protein 4; Acts as complement inhibitor by disrupting the formation of the classical C3 convertase. Isoform 3 inhibits the classical complement pathway, while membrane-bound isoform 1 inhibits deposition of C3b via both the classical and alternative complement pathways. | 0.451 |
Efcab2 | Klhl30 | ENSMUSP00000027775 | ENSMUSP00000027533 | Dynein regulatory complex protein 8; Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. | Kelch-like protein 30. | 0.496 |
Efcab2 | Susd4 | ENSMUSP00000027775 | ENSMUSP00000082873 | Dynein regulatory complex protein 8; Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. | Sushi domain-containing protein 4; Acts as complement inhibitor by disrupting the formation of the classical C3 convertase. Isoform 3 inhibits the classical complement pathway, while membrane-bound isoform 1 inhibits deposition of C3b via both the classical and alternative complement pathways. | 0.480 |
Fhad1 | Bcas3 | ENSMUSP00000101406 | ENSMUSP00000074416 | Forkhead-associated domain-containing protein 1. | Breast carcinoma-amplified sequence 3 homolog; Functions synergistically with PELP1 as a transcriptional coactivator of estrogen receptor-responsive genes. Stimulates histone acetyltransferase activity. Binds to chromatin (By similarity). Plays a role in angiogenesis. Participates in the regulation of cell polarity and directional endothelial cell migration by mediating both the activation and recruitment of CDC42 and the reorganization of the actin cytoskeleton at the cell leading edge. Promotes filipodia formation. Belongs to the BCAS3 family. | 0.580 |
Fhad1 | Sel1l3 | ENSMUSP00000101406 | ENSMUSP00000031090 | Forkhead-associated domain-containing protein 1. | Protein sel-1 homolog 3. | 0.637 |
Fhad1 | Susd4 | ENSMUSP00000101406 | ENSMUSP00000082873 | Forkhead-associated domain-containing protein 1. | Sushi domain-containing protein 4; Acts as complement inhibitor by disrupting the formation of the classical C3 convertase. Isoform 3 inhibits the classical complement pathway, while membrane-bound isoform 1 inhibits deposition of C3b via both the classical and alternative complement pathways. | 0.612 |
Fhad1 | Zfp407 | ENSMUSP00000101406 | ENSMUSP00000118361 | Forkhead-associated domain-containing protein 1. | Zinc finger protein 407. | 0.661 |
Hsd3b5 | Susd4 | ENSMUSP00000041442 | ENSMUSP00000082873 | NADPH-dependent 3-keto-steroid reductase Hsd3b5; Responsible for the reduction of the oxo group on the C-3 of 5alpha-androstane steroids. Catalyzes the conversion of dihydrotestosterone to its inactive form 5alpha-androstanediol, that does not bind androgen receptor/AR. Does not function as an isomerase. | Sushi domain-containing protein 4; Acts as complement inhibitor by disrupting the formation of the classical C3 convertase. Isoform 3 inhibits the classical complement pathway, while membrane-bound isoform 1 inhibits deposition of C3b via both the classical and alternative complement pathways. | 0.438 |
Klhl30 | Efcab2 | ENSMUSP00000027533 | ENSMUSP00000027775 | Kelch-like protein 30. | Dynein regulatory complex protein 8; Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. | 0.496 |
Klhl30 | Rhbdl2 | ENSMUSP00000027533 | ENSMUSP00000054546 | Kelch-like protein 30. | Rhomboid-related protein 2, C-terminal fragment; Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Known substrate: EFNB3 (By similarity); Belongs to the peptidase S54 family. | 0.437 |
Klhl30 | Susd4 | ENSMUSP00000027533 | ENSMUSP00000082873 | Kelch-like protein 30. | Sushi domain-containing protein 4; Acts as complement inhibitor by disrupting the formation of the classical C3 convertase. Isoform 3 inhibits the classical complement pathway, while membrane-bound isoform 1 inhibits deposition of C3b via both the classical and alternative complement pathways. | 0.543 |
Rhbdl2 | Dennd1b | ENSMUSP00000054546 | ENSMUSP00000127580 | Rhomboid-related protein 2, C-terminal fragment; Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Known substrate: EFNB3 (By similarity); Belongs to the peptidase S54 family. | DENN domain-containing protein 1B; Guanine nucleotide exchange factor (GEF) for RAB35 that acts as a regulator of T-cell receptor (TCR) internalization in TH2 cells. Acts by promoting the exchange of GDP to GTP, converting inactive GDP- bound RAB35 into its active GTP-bound form. Plays a role in clathrin- mediated endocytosis. Controls cytokine production in TH2 lymphocytes by controlling the rate of TCR internalization and routing to endosomes: acts by mediating clathrin-mediated endocytosis of TCR via its interaction with the adapter protein complex 2 (AP-2) and GEF activity. Dysregu [...] | 0.483 |
Rhbdl2 | Klhl30 | ENSMUSP00000054546 | ENSMUSP00000027533 | Rhomboid-related protein 2, C-terminal fragment; Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Known substrate: EFNB3 (By similarity); Belongs to the peptidase S54 family. | Kelch-like protein 30. | 0.437 |
Rhbdl2 | Susd4 | ENSMUSP00000054546 | ENSMUSP00000082873 | Rhomboid-related protein 2, C-terminal fragment; Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Known substrate: EFNB3 (By similarity); Belongs to the peptidase S54 family. | Sushi domain-containing protein 4; Acts as complement inhibitor by disrupting the formation of the classical C3 convertase. Isoform 3 inhibits the classical complement pathway, while membrane-bound isoform 1 inhibits deposition of C3b via both the classical and alternative complement pathways. | 0.514 |
Ribc1 | Susd4 | ENSMUSP00000026288 | ENSMUSP00000082873 | RIB43A-like with coiled-coils protein 1; Belongs to the RIB43A family. | Sushi domain-containing protein 4; Acts as complement inhibitor by disrupting the formation of the classical C3 convertase. Isoform 3 inhibits the classical complement pathway, while membrane-bound isoform 1 inhibits deposition of C3b via both the classical and alternative complement pathways. | 0.464 |