STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Gm6502Predicted gene 6502. (481 aa)    
Predicted Functional Partners:
Gm6133
Predicted gene 6133; Belongs to the universal ribosomal protein uL22 family.
      
 0.880
Gm6465
Predicted gene 6465.
      
 0.767
Pramel1
Preferentially expressed antigen in melanoma-like protein 1; May play a role in acrosome development and also in sperm maturation and motility; Belongs to the PRAME family.
  
  
 
0.745
Pramef20
PRAME family member 20.
  
  
 
0.743
Cul2
Cullin-2; Core component of multiple cullin-RING-based ECS (ElonginB/C- CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (By similarity). May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the associati [...]
    
  0.743
Gm7073
Predicted gene 7073.
   
  
 0.742
Pramel5
Preferentially-expressed antigen in melanoma-like 5.
  
  
 
0.741
Gm13084
Predicted gene 13084.
  
  
 
0.741
Oog1
Oogenesin-1; May act as a Ras-mediated signaling protein in early embryogenesis; Belongs to the PRAME family.
  
  
 
0.741
Gm10436
Predicted gene 10436.
  
  
 
0.740
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
Server load: low (24%) [HD]