node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Adar | Prune2 | ENSMUSP00000103028 | ENSMUSP00000084977 | Double-stranded RNA-specific adenosine deaminase; Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structur [...] | Protein prune homolog 2; May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells. | 0.443 |
Ccnd1 | Prune2 | ENSMUSP00000091495 | ENSMUSP00000084977 | G1/S-specific cyclin-D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...] | Protein prune homolog 2; May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells. | 0.424 |
Dydc2 | Ocel1 | ENSMUSP00000022316 | ENSMUSP00000002469 | DPY30 domain-containing 2. | Occludin/ELL domain-containing protein 1; Belongs to the ELL/occludin family. | 0.579 |
Dydc2 | Prune2 | ENSMUSP00000022316 | ENSMUSP00000084977 | DPY30 domain-containing 2. | Protein prune homolog 2; May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells. | 0.489 |
Dydc2 | Rpp25 | ENSMUSP00000022316 | ENSMUSP00000079358 | DPY30 domain-containing 2. | Ribonuclease P protein subunit p25; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences; Belongs to the histone-like Alba family. | 0.538 |
Map6 | Prune2 | ENSMUSP00000146585 | ENSMUSP00000084977 | Microtubule-associated protein 6; Involved in microtubule stabilization in many cell types, including neuronal cells. Specifically has microtubule cold stabilizing activity. Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with TMEM106B (By similarity). Regulates KIF5A-mediated axonal cargo transport (By similarity). Regulates axonal growth during neuron polarization. ECO:0000250|UniProtKB:Q96JE9. | Protein prune homolog 2; May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells. | 0.522 |
Ntrk1 | Prune2 | ENSMUSP00000029712 | ENSMUSP00000084977 | High affinity nerve growth factor receptor; Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand, it can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosph [...] | Protein prune homolog 2; May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells. | 0.443 |
Ocel1 | Dydc2 | ENSMUSP00000002469 | ENSMUSP00000022316 | Occludin/ELL domain-containing protein 1; Belongs to the ELL/occludin family. | DPY30 domain-containing 2. | 0.579 |
Ocel1 | Prune2 | ENSMUSP00000002469 | ENSMUSP00000084977 | Occludin/ELL domain-containing protein 1; Belongs to the ELL/occludin family. | Protein prune homolog 2; May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells. | 0.570 |
Ocel1 | Rpp25 | ENSMUSP00000002469 | ENSMUSP00000079358 | Occludin/ELL domain-containing protein 1; Belongs to the ELL/occludin family. | Ribonuclease P protein subunit p25; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences; Belongs to the histone-like Alba family. | 0.538 |
Prune1 | Prune2 | ENSMUSP00000015855 | ENSMUSP00000084977 | Exopolyphosphatase PRUNE1; Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Plays a role in cell proliferation, migration and differentiation, and acts as a negative regulator of NME1. Plays a role in the regulation of neurogenesis. Involved in the regulation of microtubule polymerization. | Protein prune homolog 2; May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells. | 0.430 |
Prune1 | Sdha | ENSMUSP00000015855 | ENSMUSP00000022062 | Exopolyphosphatase PRUNE1; Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Plays a role in cell proliferation, migration and differentiation, and acts as a negative regulator of NME1. Plays a role in the regulation of neurogenesis. Involved in the regulation of microtubule polymerization. | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Can act as a tumor suppressor. Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. | 0.495 |
Prune1 | Uprt | ENSMUSP00000015855 | ENSMUSP00000085175 | Exopolyphosphatase PRUNE1; Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Plays a role in cell proliferation, migration and differentiation, and acts as a negative regulator of NME1. Plays a role in the regulation of neurogenesis. Involved in the regulation of microtubule polymerization. | Uracil phosphoribosyltransferase homolog. | 0.419 |
Prune2 | Adar | ENSMUSP00000084977 | ENSMUSP00000103028 | Protein prune homolog 2; May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells. | Double-stranded RNA-specific adenosine deaminase; Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structur [...] | 0.443 |
Prune2 | Ccnd1 | ENSMUSP00000084977 | ENSMUSP00000091495 | Protein prune homolog 2; May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells. | G1/S-specific cyclin-D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...] | 0.424 |
Prune2 | Dydc2 | ENSMUSP00000084977 | ENSMUSP00000022316 | Protein prune homolog 2; May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells. | DPY30 domain-containing 2. | 0.489 |
Prune2 | Map6 | ENSMUSP00000084977 | ENSMUSP00000146585 | Protein prune homolog 2; May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells. | Microtubule-associated protein 6; Involved in microtubule stabilization in many cell types, including neuronal cells. Specifically has microtubule cold stabilizing activity. Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with TMEM106B (By similarity). Regulates KIF5A-mediated axonal cargo transport (By similarity). Regulates axonal growth during neuron polarization. ECO:0000250|UniProtKB:Q96JE9. | 0.522 |
Prune2 | Ntrk1 | ENSMUSP00000084977 | ENSMUSP00000029712 | Protein prune homolog 2; May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells. | High affinity nerve growth factor receptor; Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand, it can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosph [...] | 0.443 |
Prune2 | Ocel1 | ENSMUSP00000084977 | ENSMUSP00000002469 | Protein prune homolog 2; May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells. | Occludin/ELL domain-containing protein 1; Belongs to the ELL/occludin family. | 0.570 |
Prune2 | Prune1 | ENSMUSP00000084977 | ENSMUSP00000015855 | Protein prune homolog 2; May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells. | Exopolyphosphatase PRUNE1; Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Plays a role in cell proliferation, migration and differentiation, and acts as a negative regulator of NME1. Plays a role in the regulation of neurogenesis. Involved in the regulation of microtubule polymerization. | 0.430 |