node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Blcap | Grb10 | ENSMUSP00000085849 | ENSMUSP00000091011 | Bladder cancer-associated protein; May regulate cell proliferation and coordinate apoptosis and cell cycle progression via a novel mechanism independent of both p53/TP53 and NF-kappa-B; Belongs to the BLCAP family. | Growth factor receptor-bound protein 10; Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin [...] | 0.457 |
Blcap | Mest | ENSMUSP00000085849 | ENSMUSP00000117713 | Bladder cancer-associated protein; May regulate cell proliferation and coordinate apoptosis and cell cycle progression via a novel mechanism independent of both p53/TP53 and NF-kappa-B; Belongs to the BLCAP family. | Mesoderm-specific transcript protein; Belongs to the AB hydrolase superfamily. | 0.440 |
Blcap | Nap1l5 | ENSMUSP00000085849 | ENSMUSP00000062780 | Bladder cancer-associated protein; May regulate cell proliferation and coordinate apoptosis and cell cycle progression via a novel mechanism independent of both p53/TP53 and NF-kappa-B; Belongs to the BLCAP family. | Nucleosome assembly protein 1-like 5. | 0.501 |
Blcap | Ndn | ENSMUSP00000085849 | ENSMUSP00000045369 | Bladder cancer-associated protein; May regulate cell proliferation and coordinate apoptosis and cell cycle progression via a novel mechanism independent of both p53/TP53 and NF-kappa-B; Belongs to the BLCAP family. | Necdin; Growth suppressor that facilitates the entry of the cell into cell cycle arrest. Functionally similar to the retinoblastoma protein it binds to and represses the activity of cell-cycle-promoting proteins such as SV40 large T antigen, adenovirus E1A, and the transcription factor E2F. Necdin also interacts with p53 and works in an additive manner to inhibit cell growth. Functions also as transcription factor and binds directly to specific guanosine-rich DNA sequences. | 0.428 |
Blcap | Nnat | ENSMUSP00000085849 | ENSMUSP00000085836 | Bladder cancer-associated protein; May regulate cell proliferation and coordinate apoptosis and cell cycle progression via a novel mechanism independent of both p53/TP53 and NF-kappa-B; Belongs to the BLCAP family. | Neuronatin; May participate in the maintenance of segment identity in the hindbrain and pituitary development, and maturation or maintenance of the overall structure of the nervous system; Belongs to the neuronatin family. | 0.835 |
Blcap | Plagl1 | ENSMUSP00000085849 | ENSMUSP00000112847 | Bladder cancer-associated protein; May regulate cell proliferation and coordinate apoptosis and cell cycle progression via a novel mechanism independent of both p53/TP53 and NF-kappa-B; Belongs to the BLCAP family. | Pleiomorphic adenoma gene-like 1. | 0.447 |
Blcap | Sgce | ENSMUSP00000085849 | ENSMUSP00000111240 | Bladder cancer-associated protein; May regulate cell proliferation and coordinate apoptosis and cell cycle progression via a novel mechanism independent of both p53/TP53 and NF-kappa-B; Belongs to the BLCAP family. | Epsilon-sarcoglycan; Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. | 0.456 |
Blcap | Snrpn | ENSMUSP00000085849 | ENSMUSP00000096003 | Bladder cancer-associated protein; May regulate cell proliferation and coordinate apoptosis and cell cycle progression via a novel mechanism independent of both p53/TP53 and NF-kappa-B; Belongs to the BLCAP family. | Small nuclear ribonucleoprotein-associated protein N; May be involved in tissue-specific alternative RNA processing events. | 0.440 |
Dlk1 | Grb10 | ENSMUSP00000063104 | ENSMUSP00000091011 | Protein delta homolog 1; May have a role in neuroendocrine differentiation. Inhibits adipocyte differentiation. | Growth factor receptor-bound protein 10; Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin [...] | 0.721 |
Dlk1 | Mest | ENSMUSP00000063104 | ENSMUSP00000117713 | Protein delta homolog 1; May have a role in neuroendocrine differentiation. Inhibits adipocyte differentiation. | Mesoderm-specific transcript protein; Belongs to the AB hydrolase superfamily. | 0.698 |
Dlk1 | Nap1l5 | ENSMUSP00000063104 | ENSMUSP00000062780 | Protein delta homolog 1; May have a role in neuroendocrine differentiation. Inhibits adipocyte differentiation. | Nucleosome assembly protein 1-like 5. | 0.528 |
Dlk1 | Ndn | ENSMUSP00000063104 | ENSMUSP00000045369 | Protein delta homolog 1; May have a role in neuroendocrine differentiation. Inhibits adipocyte differentiation. | Necdin; Growth suppressor that facilitates the entry of the cell into cell cycle arrest. Functionally similar to the retinoblastoma protein it binds to and represses the activity of cell-cycle-promoting proteins such as SV40 large T antigen, adenovirus E1A, and the transcription factor E2F. Necdin also interacts with p53 and works in an additive manner to inhibit cell growth. Functions also as transcription factor and binds directly to specific guanosine-rich DNA sequences. | 0.649 |
Dlk1 | Nnat | ENSMUSP00000063104 | ENSMUSP00000085836 | Protein delta homolog 1; May have a role in neuroendocrine differentiation. Inhibits adipocyte differentiation. | Neuronatin; May participate in the maintenance of segment identity in the hindbrain and pituitary development, and maturation or maintenance of the overall structure of the nervous system; Belongs to the neuronatin family. | 0.632 |
Dlk1 | Peg10 | ENSMUSP00000063104 | ENSMUSP00000134963 | Protein delta homolog 1; May have a role in neuroendocrine differentiation. Inhibits adipocyte differentiation. | Retrotransposon-derived protein PEG10; May have a role in cell growth promotion, apoptotic resistance and hepatoma formation. Inhibits the TGF-beta signaling by interacting with the TGF-beta receptor ALK1. When overexpressed, induces the formation of cellular extension, such as filipodia in association with ALK1 (By similarity). Involved at the immediate early stage of adipocyte differentiation. May bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein (MBP) promoter. | 0.702 |
Dlk1 | Plagl1 | ENSMUSP00000063104 | ENSMUSP00000112847 | Protein delta homolog 1; May have a role in neuroendocrine differentiation. Inhibits adipocyte differentiation. | Pleiomorphic adenoma gene-like 1. | 0.698 |
Dlk1 | Sgce | ENSMUSP00000063104 | ENSMUSP00000111240 | Protein delta homolog 1; May have a role in neuroendocrine differentiation. Inhibits adipocyte differentiation. | Epsilon-sarcoglycan; Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. | 0.591 |
Dlk1 | Snrpn | ENSMUSP00000063104 | ENSMUSP00000096003 | Protein delta homolog 1; May have a role in neuroendocrine differentiation. Inhibits adipocyte differentiation. | Small nuclear ribonucleoprotein-associated protein N; May be involved in tissue-specific alternative RNA processing events. | 0.675 |
Grb10 | Blcap | ENSMUSP00000091011 | ENSMUSP00000085849 | Growth factor receptor-bound protein 10; Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin [...] | Bladder cancer-associated protein; May regulate cell proliferation and coordinate apoptosis and cell cycle progression via a novel mechanism independent of both p53/TP53 and NF-kappa-B; Belongs to the BLCAP family. | 0.457 |
Grb10 | Dlk1 | ENSMUSP00000091011 | ENSMUSP00000063104 | Growth factor receptor-bound protein 10; Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin [...] | Protein delta homolog 1; May have a role in neuroendocrine differentiation. Inhibits adipocyte differentiation. | 0.721 |
Grb10 | Mest | ENSMUSP00000091011 | ENSMUSP00000117713 | Growth factor receptor-bound protein 10; Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin [...] | Mesoderm-specific transcript protein; Belongs to the AB hydrolase superfamily. | 0.782 |