STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Eef1dEukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein); Elongation factor 1-delta; Isoform 1: EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP, regenerating EF-1- alpha for another round of transfer of aminoacyl-tRNAs to the ribosome (660 aa)    
Predicted Functional Partners:
Eef1g
Eukaryotic translation elongation factor 1 gamma; Elongation factor 1-gamma; Probably plays a role in anchoring the complex to other cellular components
   
 0.999
Eef1b2
Eukaryotic translation elongation factor 1 beta 2; Elongation factor 1-beta; EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP
   
0.994
Eef1a1
Eukaryotic translation elongation factor 1 alpha 1; Elongation factor 1-alpha 1; This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production
   
 0.988
Vars
Valine--tRNA ligase; valyl-tRNA synthetase
   
 
 0.953
Rpl4
Large subunit ribosomal protein l4e; Ribosomal protein L4; Belongs to the universal ribosomal protein uL4 family
   
 
 0.943
Rps11
Small subunit ribosomal protein s11e; Ribosomal protein S11
  
 
 0.941
Rps3
40S ribosomal protein S3; Involved in translation as a component of the 40S small ribosomal subunit (By similarity). Has endonuclease activity and plays a role in repair of damaged DNA. Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA (By similarity). Displays high binding affinity for 7,8-dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS) (By similarity). Has also been shown to bind with similar affinity to intact and damaged DNA (By similarity). St [...]
  
 
 0.939
Rplp2
Large subunit ribosomal protein lp2; 60S acidic ribosomal protein P2; Plays an important role in the elongation step of protein synthesis
  
 
 0.936
Rps8
Small subunit ribosomal protein s8e; Ribosomal protein S8; Belongs to the eukaryotic ribosomal protein eS8 family
   
 
 0.931
Rps17
Small subunit ribosomal protein s17e; Ribosomal protein S17; Belongs to the eukaryotic ribosomal protein eS17 family
   
 
 0.930
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus muscaris, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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