node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Akp3 | Alpi | ENSMUSP00000037497 | ENSMUSP00000108895 | Intestinal-type alkaline phosphatase. | Alkaline phosphatase. | 0.520 |
Akp3 | Alppl2 | ENSMUSP00000037497 | ENSMUSP00000027455 | Intestinal-type alkaline phosphatase. | Alkaline phosphatase, germ cell type. | 0.425 |
Akp3 | Gch1 | ENSMUSP00000037497 | ENSMUSP00000087405 | Intestinal-type alkaline phosphatase. | GTP cyclohydrolase 1; May positively regulate nitric oxide synthesis in endothelial cells. May be involved in dopamine synthesis. May modify pain sensitivity and persistence. | 0.906 |
Akp3 | Pts | ENSMUSP00000037497 | ENSMUSP00000034570 | Intestinal-type alkaline phosphatase. | 6-pyruvoyl tetrahydrobiopterin synthase; Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin. | 0.902 |
Alpi | Akp3 | ENSMUSP00000108895 | ENSMUSP00000037497 | Alkaline phosphatase. | Intestinal-type alkaline phosphatase. | 0.520 |
Alpi | Alppl2 | ENSMUSP00000108895 | ENSMUSP00000027455 | Alkaline phosphatase. | Alkaline phosphatase, germ cell type. | 0.440 |
Alpi | Gch1 | ENSMUSP00000108895 | ENSMUSP00000087405 | Alkaline phosphatase. | GTP cyclohydrolase 1; May positively regulate nitric oxide synthesis in endothelial cells. May be involved in dopamine synthesis. May modify pain sensitivity and persistence. | 0.901 |
Alpi | Pts | ENSMUSP00000108895 | ENSMUSP00000034570 | Alkaline phosphatase. | 6-pyruvoyl tetrahydrobiopterin synthase; Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin. | 0.900 |
Alpl | Gch1 | ENSMUSP00000030551 | ENSMUSP00000087405 | Alkaline phosphatase, tissue-nonspecific isozyme; This isozyme plays a key role in skeletal mineralization by regulating levels of diphosphate (PPi). | GTP cyclohydrolase 1; May positively regulate nitric oxide synthesis in endothelial cells. May be involved in dopamine synthesis. May modify pain sensitivity and persistence. | 0.901 |
Alpl | Pts | ENSMUSP00000030551 | ENSMUSP00000034570 | Alkaline phosphatase, tissue-nonspecific isozyme; This isozyme plays a key role in skeletal mineralization by regulating levels of diphosphate (PPi). | 6-pyruvoyl tetrahydrobiopterin synthase; Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin. | 0.900 |
Alppl2 | Akp3 | ENSMUSP00000027455 | ENSMUSP00000037497 | Alkaline phosphatase, germ cell type. | Intestinal-type alkaline phosphatase. | 0.425 |
Alppl2 | Alpi | ENSMUSP00000027455 | ENSMUSP00000108895 | Alkaline phosphatase, germ cell type. | Alkaline phosphatase. | 0.440 |
Alppl2 | Gch1 | ENSMUSP00000027455 | ENSMUSP00000087405 | Alkaline phosphatase, germ cell type. | GTP cyclohydrolase 1; May positively regulate nitric oxide synthesis in endothelial cells. May be involved in dopamine synthesis. May modify pain sensitivity and persistence. | 0.901 |
Alppl2 | Pts | ENSMUSP00000027455 | ENSMUSP00000034570 | Alkaline phosphatase, germ cell type. | 6-pyruvoyl tetrahydrobiopterin synthase; Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin. | 0.900 |
Gch1 | Akp3 | ENSMUSP00000087405 | ENSMUSP00000037497 | GTP cyclohydrolase 1; May positively regulate nitric oxide synthesis in endothelial cells. May be involved in dopamine synthesis. May modify pain sensitivity and persistence. | Intestinal-type alkaline phosphatase. | 0.906 |
Gch1 | Alpi | ENSMUSP00000087405 | ENSMUSP00000108895 | GTP cyclohydrolase 1; May positively regulate nitric oxide synthesis in endothelial cells. May be involved in dopamine synthesis. May modify pain sensitivity and persistence. | Alkaline phosphatase. | 0.901 |
Gch1 | Alpl | ENSMUSP00000087405 | ENSMUSP00000030551 | GTP cyclohydrolase 1; May positively regulate nitric oxide synthesis in endothelial cells. May be involved in dopamine synthesis. May modify pain sensitivity and persistence. | Alkaline phosphatase, tissue-nonspecific isozyme; This isozyme plays a key role in skeletal mineralization by regulating levels of diphosphate (PPi). | 0.901 |
Gch1 | Alppl2 | ENSMUSP00000087405 | ENSMUSP00000027455 | GTP cyclohydrolase 1; May positively regulate nitric oxide synthesis in endothelial cells. May be involved in dopamine synthesis. May modify pain sensitivity and persistence. | Alkaline phosphatase, germ cell type. | 0.901 |
Gch1 | Gchfr | ENSMUSP00000087405 | ENSMUSP00000060835 | GTP cyclohydrolase 1; May positively regulate nitric oxide synthesis in endothelial cells. May be involved in dopamine synthesis. May modify pain sensitivity and persistence. | GTP cyclohydrolase 1 feedback regulatory protein; Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1. This inhibition is reversed by L-phenylalanine (By similarity). | 0.997 |
Gch1 | Itpa | ENSMUSP00000087405 | ENSMUSP00000099482 | GTP cyclohydrolase 1; May positively regulate nitric oxide synthesis in endothelial cells. May be involved in dopamine synthesis. May modify pain sensitivity and persistence. | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.933 |