node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Aass | Btd | ENSMUSP00000031707 | ENSMUSP00000087608 | Alpha-aminoadipic semialdehyde synthase, mitochondrial; Bifunctional enzyme that catalyzes the first two steps in lysine degradation. The N-terminal and the C-terminal contain lysine- oxoglutarate reductase and saccharopine dehydrogenase activity, respectively. | Biotinidase; Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation. | 0.818 |
Aass | Glud1 | ENSMUSP00000031707 | ENSMUSP00000022322 | Alpha-aminoadipic semialdehyde synthase, mitochondrial; Bifunctional enzyme that catalyzes the first two steps in lysine degradation. The N-terminal and the C-terminal contain lysine- oxoglutarate reductase and saccharopine dehydrogenase activity, respectively. | Glutamate dehydrogenase 1, mitochondrial; Mitochondrial glutamate dehydrogenase that converts L- glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle. May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | 0.532 |
Aass | Pcca | ENSMUSP00000031707 | ENSMUSP00000038763 | Alpha-aminoadipic semialdehyde synthase, mitochondrial; Bifunctional enzyme that catalyzes the first two steps in lysine degradation. The N-terminal and the C-terminal contain lysine- oxoglutarate reductase and saccharopine dehydrogenase activity, respectively. | Propionyl-CoA carboxylase alpha chain, mitochondrial; This is one of the 2 subunits of the biotin-dependent propionyl-CoA carboxylase (PCC), a mitochondrial enzyme involved in the catabolism of odd chain fatty acids, branched-chain amino acids isoleucine, threonine, methionine, and valine and other metabolites. Propionyl-CoA carboxylase catalyzes the carboxylation of propionyl- CoA/propanoyl-CoA to D-methylmalonyl-CoA/(S)-methylmalonyl-CoA (By similarity). Within the holoenzyme, the alpha subunit catalyzes the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl car [...] | 0.434 |
Asb14 | Btd | ENSMUSP00000087810 | ENSMUSP00000087608 | Ankyrin repeat and SOCS box protein 14; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins; Belongs to the ankyrin SOCS box (ASB) family. | Biotinidase; Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation. | 0.566 |
Btd | Aass | ENSMUSP00000087608 | ENSMUSP00000031707 | Biotinidase; Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation. | Alpha-aminoadipic semialdehyde synthase, mitochondrial; Bifunctional enzyme that catalyzes the first two steps in lysine degradation. The N-terminal and the C-terminal contain lysine- oxoglutarate reductase and saccharopine dehydrogenase activity, respectively. | 0.818 |
Btd | Asb14 | ENSMUSP00000087608 | ENSMUSP00000087810 | Biotinidase; Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation. | Ankyrin repeat and SOCS box protein 14; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins; Belongs to the ankyrin SOCS box (ASB) family. | 0.566 |
Btd | C7 | ENSMUSP00000087608 | ENSMUSP00000106317 | Biotinidase; Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation. | Complement component 7. | 0.418 |
Btd | Glud1 | ENSMUSP00000087608 | ENSMUSP00000022322 | Biotinidase; Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation. | Glutamate dehydrogenase 1, mitochondrial; Mitochondrial glutamate dehydrogenase that converts L- glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle. May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | 0.424 |
Btd | Glyctk | ENSMUSP00000087608 | ENSMUSP00000047761 | Biotinidase; Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation. | Glycerate kinase; Belongs to the glycerate kinase type-2 family. | 0.451 |
Btd | Hlcs | ENSMUSP00000087608 | ENSMUSP00000130981 | Biotinidase; Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation. | Biotin--[propionyl-CoA-carboxylase [ATP-hydrolyzing]] ligase; Biotin--protein ligase catalyzing the biotinylation of the 4 biotin-dependent carboxylases acetyl-CoA-carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, and methylcrotonyl-CoA carboxylase. | 0.985 |
Btd | Odr4 | ENSMUSP00000087608 | ENSMUSP00000107544 | Biotinidase; Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation. | Protein odr-4 homolog; May play a role in the trafficking of a subset of G-protein coupled receptors; Belongs to the ODR-4 family. | 0.410 |
Btd | Pcca | ENSMUSP00000087608 | ENSMUSP00000038763 | Biotinidase; Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation. | Propionyl-CoA carboxylase alpha chain, mitochondrial; This is one of the 2 subunits of the biotin-dependent propionyl-CoA carboxylase (PCC), a mitochondrial enzyme involved in the catabolism of odd chain fatty acids, branched-chain amino acids isoleucine, threonine, methionine, and valine and other metabolites. Propionyl-CoA carboxylase catalyzes the carboxylation of propionyl- CoA/propanoyl-CoA to D-methylmalonyl-CoA/(S)-methylmalonyl-CoA (By similarity). Within the holoenzyme, the alpha subunit catalyzes the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl car [...] | 0.424 |
Btd | Pcx | ENSMUSP00000087608 | ENSMUSP00000063825 | Biotinidase; Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation. | Pyruvate carboxylase, mitochondrial; Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate. | 0.609 |
Btd | Slc5a6 | ENSMUSP00000087608 | ENSMUSP00000110316 | Biotinidase; Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation. | Sodium-dependent multivitamin transporter; Transports pantothenate, biotin and lipoate in the presence of sodium; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. | 0.486 |
C7 | Btd | ENSMUSP00000106317 | ENSMUSP00000087608 | Complement component 7. | Biotinidase; Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation. | 0.418 |
Glud1 | Aass | ENSMUSP00000022322 | ENSMUSP00000031707 | Glutamate dehydrogenase 1, mitochondrial; Mitochondrial glutamate dehydrogenase that converts L- glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle. May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | Alpha-aminoadipic semialdehyde synthase, mitochondrial; Bifunctional enzyme that catalyzes the first two steps in lysine degradation. The N-terminal and the C-terminal contain lysine- oxoglutarate reductase and saccharopine dehydrogenase activity, respectively. | 0.532 |
Glud1 | Btd | ENSMUSP00000022322 | ENSMUSP00000087608 | Glutamate dehydrogenase 1, mitochondrial; Mitochondrial glutamate dehydrogenase that converts L- glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle. May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | Biotinidase; Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation. | 0.424 |
Glud1 | Pcca | ENSMUSP00000022322 | ENSMUSP00000038763 | Glutamate dehydrogenase 1, mitochondrial; Mitochondrial glutamate dehydrogenase that converts L- glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle. May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | Propionyl-CoA carboxylase alpha chain, mitochondrial; This is one of the 2 subunits of the biotin-dependent propionyl-CoA carboxylase (PCC), a mitochondrial enzyme involved in the catabolism of odd chain fatty acids, branched-chain amino acids isoleucine, threonine, methionine, and valine and other metabolites. Propionyl-CoA carboxylase catalyzes the carboxylation of propionyl- CoA/propanoyl-CoA to D-methylmalonyl-CoA/(S)-methylmalonyl-CoA (By similarity). Within the holoenzyme, the alpha subunit catalyzes the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl car [...] | 0.445 |
Glud1 | Pcx | ENSMUSP00000022322 | ENSMUSP00000063825 | Glutamate dehydrogenase 1, mitochondrial; Mitochondrial glutamate dehydrogenase that converts L- glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle. May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | Pyruvate carboxylase, mitochondrial; Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate. | 0.943 |
Glyctk | Btd | ENSMUSP00000047761 | ENSMUSP00000087608 | Glycerate kinase; Belongs to the glycerate kinase type-2 family. | Biotinidase; Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation. | 0.451 |