node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ccdc92 | Hemk1 | ENSMUSP00000038075 | ENSMUSP00000035196 | Coiled-coil domain-containing protein 92. | MTRF1L release factor glutamine methyltransferase; N5-glutamine methyltransferase responsible for the methylation of the glutamine residue in the universally conserved GGQ motif of the mitochondrial translation release factor MTRF1L. | 0.443 |
Ccdc92 | Nt5dc2 | ENSMUSP00000038075 | ENSMUSP00000087680 | Coiled-coil domain-containing protein 92. | 5'-nucleotidase domain-containing 2. | 0.519 |
Ccdc92 | Zfp664 | ENSMUSP00000038075 | ENSMUSP00000107048 | Coiled-coil domain-containing protein 92. | Zinc finger protein 664; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.819 |
Cenpw | Nt5dc2 | ENSMUSP00000097565 | ENSMUSP00000087680 | Centromere protein W; Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation (By similarity). The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres (By similarity). Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP [...] | 5'-nucleotidase domain-containing 2. | 0.507 |
Cenpw | Ube2t | ENSMUSP00000097565 | ENSMUSP00000027687 | Centromere protein W; Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation (By similarity). The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres (By similarity). Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP [...] | Ubiquitin-conjugating enzyme E2 T; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in mitomycin-C (MMC)-induced DNA repair: acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCL and FANCI. May contribute to ubiquitination and degradation of BRCA1. In vitro able to promote polyubiquitination using a [...] | 0.523 |
Hemk1 | Ccdc92 | ENSMUSP00000035196 | ENSMUSP00000038075 | MTRF1L release factor glutamine methyltransferase; N5-glutamine methyltransferase responsible for the methylation of the glutamine residue in the universally conserved GGQ motif of the mitochondrial translation release factor MTRF1L. | Coiled-coil domain-containing protein 92. | 0.443 |
Hemk1 | Nt5dc2 | ENSMUSP00000035196 | ENSMUSP00000087680 | MTRF1L release factor glutamine methyltransferase; N5-glutamine methyltransferase responsible for the methylation of the glutamine residue in the universally conserved GGQ motif of the mitochondrial translation release factor MTRF1L. | 5'-nucleotidase domain-containing 2. | 0.453 |
Hemk1 | Smim4 | ENSMUSP00000035196 | ENSMUSP00000145018 | MTRF1L release factor glutamine methyltransferase; N5-glutamine methyltransferase responsible for the methylation of the glutamine residue in the universally conserved GGQ motif of the mitochondrial translation release factor MTRF1L. | Small integral membrane protein 4; Belongs to the SMIM4 family. | 0.523 |
Lratd1 | Nt5dc2 | ENSMUSP00000020926 | ENSMUSP00000087680 | Protein LRATD1; May play a role in cell morphology and motility. Belongs to the LRATD family. | 5'-nucleotidase domain-containing 2. | 0.532 |
Mtmr9 | Nt5dc2 | ENSMUSP00000059894 | ENSMUSP00000087680 | Myotubularin-related protein 9; Acts as an adapter for myotubularin-related phosphatases. Increases lipid phosphatase MTMR6 catalytic activity, specifically towards phosphatidylinositol 3,5-bisphosphate, and MTMR6 binding affinity for phosphorylated phosphatidylinositols (By similarity). Positively regulates lipid phosphatase MTMR7 catalytic activity. The formation of the MTMR6-MTMR9 complex, stabilizes both MTMR6 and MTMR9 protein levels (By similarity). Plays a role in the late stages of macropinocytosis possibly by regulating MTMR6-mediated dephosphorylation of phosphatidylinositol [...] | 5'-nucleotidase domain-containing 2. | 0.454 |
Mtmr9 | Ppm1m | ENSMUSP00000059894 | ENSMUSP00000117908 | Myotubularin-related protein 9; Acts as an adapter for myotubularin-related phosphatases. Increases lipid phosphatase MTMR6 catalytic activity, specifically towards phosphatidylinositol 3,5-bisphosphate, and MTMR6 binding affinity for phosphorylated phosphatidylinositols (By similarity). Positively regulates lipid phosphatase MTMR7 catalytic activity. The formation of the MTMR6-MTMR9 complex, stabilizes both MTMR6 and MTMR9 protein levels (By similarity). Plays a role in the late stages of macropinocytosis possibly by regulating MTMR6-mediated dephosphorylation of phosphatidylinositol [...] | Protein phosphatase 1M; Belongs to the PP2C family. | 0.404 |
Mtmr9 | Pudp | ENSMUSP00000059894 | ENSMUSP00000057378 | Myotubularin-related protein 9; Acts as an adapter for myotubularin-related phosphatases. Increases lipid phosphatase MTMR6 catalytic activity, specifically towards phosphatidylinositol 3,5-bisphosphate, and MTMR6 binding affinity for phosphorylated phosphatidylinositols (By similarity). Positively regulates lipid phosphatase MTMR7 catalytic activity. The formation of the MTMR6-MTMR9 complex, stabilizes both MTMR6 and MTMR9 protein levels (By similarity). Plays a role in the late stages of macropinocytosis possibly by regulating MTMR6-mediated dephosphorylation of phosphatidylinositol [...] | Pseudouridine-5'-phosphatase; Dephosphorylates pseudouridine 5'-phosphate, a potential intermediate in rRNA degradation. Pseudouridine is then excreted intact in urine. | 0.468 |
Nt5dc2 | Ccdc92 | ENSMUSP00000087680 | ENSMUSP00000038075 | 5'-nucleotidase domain-containing 2. | Coiled-coil domain-containing protein 92. | 0.519 |
Nt5dc2 | Cenpw | ENSMUSP00000087680 | ENSMUSP00000097565 | 5'-nucleotidase domain-containing 2. | Centromere protein W; Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation (By similarity). The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres (By similarity). Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP [...] | 0.507 |
Nt5dc2 | Hemk1 | ENSMUSP00000087680 | ENSMUSP00000035196 | 5'-nucleotidase domain-containing 2. | MTRF1L release factor glutamine methyltransferase; N5-glutamine methyltransferase responsible for the methylation of the glutamine residue in the universally conserved GGQ motif of the mitochondrial translation release factor MTRF1L. | 0.453 |
Nt5dc2 | Lratd1 | ENSMUSP00000087680 | ENSMUSP00000020926 | 5'-nucleotidase domain-containing 2. | Protein LRATD1; May play a role in cell morphology and motility. Belongs to the LRATD family. | 0.532 |
Nt5dc2 | Mtmr9 | ENSMUSP00000087680 | ENSMUSP00000059894 | 5'-nucleotidase domain-containing 2. | Myotubularin-related protein 9; Acts as an adapter for myotubularin-related phosphatases. Increases lipid phosphatase MTMR6 catalytic activity, specifically towards phosphatidylinositol 3,5-bisphosphate, and MTMR6 binding affinity for phosphorylated phosphatidylinositols (By similarity). Positively regulates lipid phosphatase MTMR7 catalytic activity. The formation of the MTMR6-MTMR9 complex, stabilizes both MTMR6 and MTMR9 protein levels (By similarity). Plays a role in the late stages of macropinocytosis possibly by regulating MTMR6-mediated dephosphorylation of phosphatidylinositol [...] | 0.454 |
Nt5dc2 | Ppm1m | ENSMUSP00000087680 | ENSMUSP00000117908 | 5'-nucleotidase domain-containing 2. | Protein phosphatase 1M; Belongs to the PP2C family. | 0.524 |
Nt5dc2 | Pudp | ENSMUSP00000087680 | ENSMUSP00000057378 | 5'-nucleotidase domain-containing 2. | Pseudouridine-5'-phosphatase; Dephosphorylates pseudouridine 5'-phosphate, a potential intermediate in rRNA degradation. Pseudouridine is then excreted intact in urine. | 0.487 |
Nt5dc2 | Smim4 | ENSMUSP00000087680 | ENSMUSP00000145018 | 5'-nucleotidase domain-containing 2. | Small integral membrane protein 4; Belongs to the SMIM4 family. | 0.556 |