| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Aatf | Bysl | ENSMUSP00000018841 | ENSMUSP00000024783 | Protein AATF; May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression (By similarity). Belongs to the AATF family. | Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits; Belongs to the bystin family. | 0.954 |
| Aatf | Dimt1 | ENSMUSP00000018841 | ENSMUSP00000022203 | Protein AATF; May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression (By similarity). Belongs to the AATF family. | Probable dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle. Involved in the pre-rRNA processing steps leading to small-subunit rRNA production independently of its RNA-modifying catalytic activity. | 0.802 |
| Aatf | Gcc1 | ENSMUSP00000018841 | ENSMUSP00000087997 | Protein AATF; May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression (By similarity). Belongs to the AATF family. | GRIP and coiled-coil domain-containing protein 1; Probably involved in maintaining Golgi structure. | 0.836 |
| Aatf | Heatr1 | ENSMUSP00000018841 | ENSMUSP00000054084 | Protein AATF; May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression (By similarity). Belongs to the AATF family. | HEAT repeat-containing 1. | 0.889 |
| Aatf | Imp4 | ENSMUSP00000018841 | ENSMUSP00000027303 | Protein AATF; May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression (By similarity). Belongs to the AATF family. | U3 small nucleolar ribonucleoprotein protein IMP4; Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing (By similarity). | 0.935 |
| Aatf | Nob1 | ENSMUSP00000018841 | ENSMUSP00000003946 | Protein AATF; May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression (By similarity). Belongs to the AATF family. | RNA-binding protein NOB1; May play a role in mRNA degradation (By similarity). Endonuclease required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits (By similarity). | 0.718 |
| Aatf | Nop14 | ENSMUSP00000018841 | ENSMUSP00000038382 | Protein AATF; May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression (By similarity). Belongs to the AATF family. | Nucleolar protein 14; Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm (By similarity). | 0.986 |
| Aatf | Pwp2 | ENSMUSP00000018841 | ENSMUSP00000045812 | Protein AATF; May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression (By similarity). Belongs to the AATF family. | Periodic tryptophan protein 2 homolog. | 0.938 |
| Aatf | Tsr1 | ENSMUSP00000018841 | ENSMUSP00000039027 | Protein AATF; May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression (By similarity). Belongs to the AATF family. | Pre-rRNA-processing protein TSR1 homolog; Required during maturation of the 40S ribosomal subunit in the nucleolus. | 0.830 |
| Bysl | Aatf | ENSMUSP00000024783 | ENSMUSP00000018841 | Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits; Belongs to the bystin family. | Protein AATF; May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression (By similarity). Belongs to the AATF family. | 0.954 |
| Bysl | Dimt1 | ENSMUSP00000024783 | ENSMUSP00000022203 | Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits; Belongs to the bystin family. | Probable dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle. Involved in the pre-rRNA processing steps leading to small-subunit rRNA production independently of its RNA-modifying catalytic activity. | 0.982 |
| Bysl | Gcc1 | ENSMUSP00000024783 | ENSMUSP00000087997 | Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits; Belongs to the bystin family. | GRIP and coiled-coil domain-containing protein 1; Probably involved in maintaining Golgi structure. | 0.876 |
| Bysl | Heatr1 | ENSMUSP00000024783 | ENSMUSP00000054084 | Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits; Belongs to the bystin family. | HEAT repeat-containing 1. | 0.943 |
| Bysl | Imp4 | ENSMUSP00000024783 | ENSMUSP00000027303 | Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits; Belongs to the bystin family. | U3 small nucleolar ribonucleoprotein protein IMP4; Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing (By similarity). | 0.974 |
| Bysl | Nob1 | ENSMUSP00000024783 | ENSMUSP00000003946 | Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits; Belongs to the bystin family. | RNA-binding protein NOB1; May play a role in mRNA degradation (By similarity). Endonuclease required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits (By similarity). | 0.998 |
| Bysl | Nop14 | ENSMUSP00000024783 | ENSMUSP00000038382 | Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits; Belongs to the bystin family. | Nucleolar protein 14; Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm (By similarity). | 0.995 |
| Bysl | Pwp2 | ENSMUSP00000024783 | ENSMUSP00000045812 | Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits; Belongs to the bystin family. | Periodic tryptophan protein 2 homolog. | 0.986 |
| Bysl | Tsr1 | ENSMUSP00000024783 | ENSMUSP00000039027 | Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits; Belongs to the bystin family. | Pre-rRNA-processing protein TSR1 homolog; Required during maturation of the 40S ribosomal subunit in the nucleolus. | 0.998 |
| Dimt1 | Aatf | ENSMUSP00000022203 | ENSMUSP00000018841 | Probable dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle. Involved in the pre-rRNA processing steps leading to small-subunit rRNA production independently of its RNA-modifying catalytic activity. | Protein AATF; May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression (By similarity). Belongs to the AATF family. | 0.802 |
| Dimt1 | Bysl | ENSMUSP00000022203 | ENSMUSP00000024783 | Probable dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle. Involved in the pre-rRNA processing steps leading to small-subunit rRNA production independently of its RNA-modifying catalytic activity. | Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits; Belongs to the bystin family. | 0.982 |
