| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Agtr2 | Mtus1 | ENSMUSP00000086592 | ENSMUSP00000059503 | Type-2 angiotensin II receptor; Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation. | Microtubule-associated tumor suppressor 1 homolog; Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. | 0.584 |
| Ckap5 | Mtus1 | ENSMUSP00000106970 | ENSMUSP00000059503 | Cytoskeleton-associated protein 5; Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Acts as processive microtubule polymerase. Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles. In spindle formation protects kinetochore microtubules from depolymerization by KIF2C and has an essential role in centrosomal microtubule assembly independently of KIF2C activity. Contributes to centrosome integrity. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stab [...] | Microtubule-associated tumor suppressor 1 homolog; Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. | 0.455 |
| Elmod2 | Mtus1 | ENSMUSP00000137044 | ENSMUSP00000059503 | ELMO domain-containing protein 2; Acts as a GTPase-activating protein (GAP) toward guanine nucleotide exchange factors like ARL2, ARL3, ARF1 and ARF6, but not for GTPases outside the Arf family. | Microtubule-associated tumor suppressor 1 homolog; Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. | 0.519 |
| Kcnk3 | Mtus1 | ENSMUSP00000098987 | ENSMUSP00000059503 | Potassium channel subfamily K member 3; pH-dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from potassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassium concentration is low. When external potassium concentration is high, current is inward. | Microtubule-associated tumor suppressor 1 homolog; Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. | 0.467 |
| Map7d1 | Mtus1 | ENSMUSP00000054338 | ENSMUSP00000059503 | MAP7 domain-containing protein 1; Belongs to the MAP7 family. | Microtubule-associated tumor suppressor 1 homolog; Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. | 0.444 |
| Mtus1 | Agtr2 | ENSMUSP00000059503 | ENSMUSP00000086592 | Microtubule-associated tumor suppressor 1 homolog; Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. | Type-2 angiotensin II receptor; Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation. | 0.584 |
| Mtus1 | Ckap5 | ENSMUSP00000059503 | ENSMUSP00000106970 | Microtubule-associated tumor suppressor 1 homolog; Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. | Cytoskeleton-associated protein 5; Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Acts as processive microtubule polymerase. Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles. In spindle formation protects kinetochore microtubules from depolymerization by KIF2C and has an essential role in centrosomal microtubule assembly independently of KIF2C activity. Contributes to centrosome integrity. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stab [...] | 0.455 |
| Mtus1 | Elmod2 | ENSMUSP00000059503 | ENSMUSP00000137044 | Microtubule-associated tumor suppressor 1 homolog; Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. | ELMO domain-containing protein 2; Acts as a GTPase-activating protein (GAP) toward guanine nucleotide exchange factors like ARL2, ARL3, ARF1 and ARF6, but not for GTPases outside the Arf family. | 0.519 |
| Mtus1 | Kcnk3 | ENSMUSP00000059503 | ENSMUSP00000098987 | Microtubule-associated tumor suppressor 1 homolog; Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. | Potassium channel subfamily K member 3; pH-dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from potassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassium concentration is low. When external potassium concentration is high, current is inward. | 0.467 |
| Mtus1 | Map7d1 | ENSMUSP00000059503 | ENSMUSP00000054338 | Microtubule-associated tumor suppressor 1 homolog; Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. | MAP7 domain-containing protein 1; Belongs to the MAP7 family. | 0.444 |
| Mtus1 | Stxbp6 | ENSMUSP00000059503 | ENSMUSP00000052639 | Microtubule-associated tumor suppressor 1 homolog; Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. | Syntaxin-binding protein 6; Forms non-fusogenic complexes with SNAP25 and STX1A and may thereby modulate the formation of functional SNARE complexes and exocytosis. | 0.532 |
| Mtus1 | Tmem117 | ENSMUSP00000059503 | ENSMUSP00000079038 | Microtubule-associated tumor suppressor 1 homolog; Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. | Transmembrane protein 117; Involved in endoplasmic reticulum (ER) stress-induced cell death pathway; Belongs to the TMEM117 family. | 0.465 |
| Mtus1 | Uhrf1bp1 | ENSMUSP00000059503 | ENSMUSP00000110499 | Microtubule-associated tumor suppressor 1 homolog; Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. | UHRF1 (ICBP90)-binding protein 1. | 0.443 |
| Mtus1 | Upp2 | ENSMUSP00000059503 | ENSMUSP00000060437 | Microtubule-associated tumor suppressor 1 homolog; Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. | Uridine phosphorylase 2; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity). | 0.469 |
| Mtus1 | Zfyve16 | ENSMUSP00000059503 | ENSMUSP00000022217 | Microtubule-associated tumor suppressor 1 homolog; Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. | Zinc finger FYVE domain-containing protein 16; May be involved in regulating membrane trafficking in the endosomal pathway. Overexpression induces endosome aggregation. Required to target TOM1 to endosomes (By similarity). | 0.506 |
| Stxbp6 | Mtus1 | ENSMUSP00000052639 | ENSMUSP00000059503 | Syntaxin-binding protein 6; Forms non-fusogenic complexes with SNAP25 and STX1A and may thereby modulate the formation of functional SNARE complexes and exocytosis. | Microtubule-associated tumor suppressor 1 homolog; Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. | 0.532 |
| Tmem117 | Mtus1 | ENSMUSP00000079038 | ENSMUSP00000059503 | Transmembrane protein 117; Involved in endoplasmic reticulum (ER) stress-induced cell death pathway; Belongs to the TMEM117 family. | Microtubule-associated tumor suppressor 1 homolog; Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. | 0.465 |
| Uhrf1bp1 | Mtus1 | ENSMUSP00000110499 | ENSMUSP00000059503 | UHRF1 (ICBP90)-binding protein 1. | Microtubule-associated tumor suppressor 1 homolog; Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. | 0.443 |
| Upp2 | Mtus1 | ENSMUSP00000060437 | ENSMUSP00000059503 | Uridine phosphorylase 2; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity). | Microtubule-associated tumor suppressor 1 homolog; Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. | 0.469 |
| Zfyve16 | Mtus1 | ENSMUSP00000022217 | ENSMUSP00000059503 | Zinc finger FYVE domain-containing protein 16; May be involved in regulating membrane trafficking in the endosomal pathway. Overexpression induces endosome aggregation. Required to target TOM1 to endosomes (By similarity). | Microtubule-associated tumor suppressor 1 homolog; Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. | 0.506 |
