node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cd109 | Cd151 | ENSMUSP00000091330 | ENSMUSP00000101622 | CD109 antigen; Modulates negatively TGFB1 signaling in keratinocytes. | CD151 antigen; Essential for the proper assembly of the glomerular and tubular basement membranes in kidney; Belongs to the tetraspanin (TM4SF) family. | 0.597 |
Cd109 | Cd248 | ENSMUSP00000091330 | ENSMUSP00000070847 | CD109 antigen; Modulates negatively TGFB1 signaling in keratinocytes. | Endosialin; May play a role in angiogenesis or vascular function. | 0.629 |
Cd109 | Cd276 | ENSMUSP00000091330 | ENSMUSP00000129418 | CD109 antigen; Modulates negatively TGFB1 signaling in keratinocytes. | CD276 antigen; Modulates T-cell-mediated immune responses and the development of acute and chronic transplant rejection. Plays a positive regulatory role in bone formation and has a dual role in the bone- immune interface. Induces antitumor immunity as it activates both acquired and innate immunity leading to natural killer cell and CD8 T- cell dependent killing of tumor cells. Belongs to the immunoglobulin superfamily. BTN/MOG family. | 0.534 |
Cd109 | Cd63 | ENSMUSP00000091330 | ENSMUSP00000151313 | CD109 antigen; Modulates negatively TGFB1 signaling in keratinocytes. | CD63 antigen; Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal tr [...] | 0.531 |
Cd109 | Cd81 | ENSMUSP00000091330 | ENSMUSP00000043768 | CD109 antigen; Modulates negatively TGFB1 signaling in keratinocytes. | CD81 antigen; Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Essential for trafficking and compartmentalization of CD19 receptor on the cell surface of activated B cells. Upon initial encounter with a microbial pathogen, enables the assembly of CD19-CR2 and B cell receptor complexes at signaling TERMs, lowering the threshold dose of antigen required to trigger B cell clonal expansion and humoral immune response (By similarity). In T cells, associates with CD4 or [...] | 0.529 |
Cd109 | Cd9 | ENSMUSP00000091330 | ENSMUSP00000032492 | CD109 antigen; Modulates negatively TGFB1 signaling in keratinocytes. | CD9 antigen; Integral membrane protein associated with integrins, which regulates different processes, such as sperm-egg fusion, platelet activation and aggregation, and cell adhesion. Present at the cell surface of oocytes and plays a key role in sperm-egg fusion, possibly by organizing multiprotein complexes and the morphology of the membrane required for the fusion. In myoblasts, associates with CD81 and PTGFRN and inhibits myotube fusion during muscle regeneration. In macrophages, associates with CD9 and beta-1 and beta-2 integrins, and prevents macrophage fusion into multinucleate [...] | 0.721 |
Cd109 | Emp1 | ENSMUSP00000091330 | ENSMUSP00000145069 | CD109 antigen; Modulates negatively TGFB1 signaling in keratinocytes. | Epithelial membrane protein 1. | 0.534 |
Cd109 | Itga2b | ENSMUSP00000091330 | ENSMUSP00000099375 | CD109 antigen; Modulates negatively TGFB1 signaling in keratinocytes. | Integrin alpha-IIb heavy chain; Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface. | 0.516 |
Cd109 | Itgb3 | ENSMUSP00000091330 | ENSMUSP00000021028 | CD109 antigen; Modulates negatively TGFB1 signaling in keratinocytes. | Integrin beta-3; Integrin alpha-V/beta-3 (ITGAV:ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIB/beta-3 (ITGA2B:ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIB/beta-3 and alpha- V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIB/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A- G-D-V in fibrinogen gamma chain. Following ac [...] | 0.530 |
Cd109 | Tgfb1 | ENSMUSP00000091330 | ENSMUSP00000002678 | CD109 antigen; Modulates negatively TGFB1 signaling in keratinocytes. | Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration. Activation into mature form follows different [...] | 0.770 |
Cd151 | Cd109 | ENSMUSP00000101622 | ENSMUSP00000091330 | CD151 antigen; Essential for the proper assembly of the glomerular and tubular basement membranes in kidney; Belongs to the tetraspanin (TM4SF) family. | CD109 antigen; Modulates negatively TGFB1 signaling in keratinocytes. | 0.597 |
Cd151 | Cd248 | ENSMUSP00000101622 | ENSMUSP00000070847 | CD151 antigen; Essential for the proper assembly of the glomerular and tubular basement membranes in kidney; Belongs to the tetraspanin (TM4SF) family. | Endosialin; May play a role in angiogenesis or vascular function. | 0.504 |
Cd151 | Cd63 | ENSMUSP00000101622 | ENSMUSP00000151313 | CD151 antigen; Essential for the proper assembly of the glomerular and tubular basement membranes in kidney; Belongs to the tetraspanin (TM4SF) family. | CD63 antigen; Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal tr [...] | 0.920 |
Cd151 | Cd81 | ENSMUSP00000101622 | ENSMUSP00000043768 | CD151 antigen; Essential for the proper assembly of the glomerular and tubular basement membranes in kidney; Belongs to the tetraspanin (TM4SF) family. | CD81 antigen; Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Essential for trafficking and compartmentalization of CD19 receptor on the cell surface of activated B cells. Upon initial encounter with a microbial pathogen, enables the assembly of CD19-CR2 and B cell receptor complexes at signaling TERMs, lowering the threshold dose of antigen required to trigger B cell clonal expansion and humoral immune response (By similarity). In T cells, associates with CD4 or [...] | 0.906 |
Cd151 | Cd9 | ENSMUSP00000101622 | ENSMUSP00000032492 | CD151 antigen; Essential for the proper assembly of the glomerular and tubular basement membranes in kidney; Belongs to the tetraspanin (TM4SF) family. | CD9 antigen; Integral membrane protein associated with integrins, which regulates different processes, such as sperm-egg fusion, platelet activation and aggregation, and cell adhesion. Present at the cell surface of oocytes and plays a key role in sperm-egg fusion, possibly by organizing multiprotein complexes and the morphology of the membrane required for the fusion. In myoblasts, associates with CD81 and PTGFRN and inhibits myotube fusion during muscle regeneration. In macrophages, associates with CD9 and beta-1 and beta-2 integrins, and prevents macrophage fusion into multinucleate [...] | 0.871 |
Cd248 | Cd109 | ENSMUSP00000070847 | ENSMUSP00000091330 | Endosialin; May play a role in angiogenesis or vascular function. | CD109 antigen; Modulates negatively TGFB1 signaling in keratinocytes. | 0.629 |
Cd248 | Cd151 | ENSMUSP00000070847 | ENSMUSP00000101622 | Endosialin; May play a role in angiogenesis or vascular function. | CD151 antigen; Essential for the proper assembly of the glomerular and tubular basement membranes in kidney; Belongs to the tetraspanin (TM4SF) family. | 0.504 |
Cd248 | Cd276 | ENSMUSP00000070847 | ENSMUSP00000129418 | Endosialin; May play a role in angiogenesis or vascular function. | CD276 antigen; Modulates T-cell-mediated immune responses and the development of acute and chronic transplant rejection. Plays a positive regulatory role in bone formation and has a dual role in the bone- immune interface. Induces antitumor immunity as it activates both acquired and innate immunity leading to natural killer cell and CD8 T- cell dependent killing of tumor cells. Belongs to the immunoglobulin superfamily. BTN/MOG family. | 0.407 |
Cd248 | Cd63 | ENSMUSP00000070847 | ENSMUSP00000151313 | Endosialin; May play a role in angiogenesis or vascular function. | CD63 antigen; Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal tr [...] | 0.460 |
Cd248 | Cd81 | ENSMUSP00000070847 | ENSMUSP00000043768 | Endosialin; May play a role in angiogenesis or vascular function. | CD81 antigen; Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Essential for trafficking and compartmentalization of CD19 receptor on the cell surface of activated B cells. Upon initial encounter with a microbial pathogen, enables the assembly of CD19-CR2 and B cell receptor complexes at signaling TERMs, lowering the threshold dose of antigen required to trigger B cell clonal expansion and humoral immune response (By similarity). In T cells, associates with CD4 or [...] | 0.480 |