node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Abcc6 | Arsj | ENSMUSP00000002850 | ENSMUSP00000091511 | Multidrug resistance-associated protein 6; May participate directly in the active transport of drugs into subcellular organelles or influence drug distribution indirectly. Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. | Arylsulfatase J. | 0.617 |
Abcc6 | Enpp1 | ENSMUSP00000002850 | ENSMUSP00000114273 | Multidrug resistance-associated protein 6; May participate directly in the active transport of drugs into subcellular organelles or influence drug distribution indirectly. Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. | Ectonucleotide pyrophosphatase/phosphodiesterase family member 1, secreted form; Nucleotide pyrophosphatase that generates diphosphate (PPi) and functions in bone mineralization and soft tissue calcification by regulating pyrophosphate levels. PPi inhibits bone mineralization and soft tissue calcification by binding to nascent hydroxyapatite crystals, thereby preventing further growth of these crystals. Preferentially hydrolyzes ATP, but can also hydrolyze other nucleoside 5' triphosphates such as GTP, CTP, TTP and UTP to their corresponding monophosphates with release of pyrophosphate [...] | 0.757 |
Arsa | Arsg | ENSMUSP00000127646 | ENSMUSP00000020928 | Arylsulfatase A; Hydrolyzes cerebroside sulfate. Belongs to the sulfatase family. | Arylsulfatase G; Displays arylsulfatase activity with pseudosubstrates at acidic pH, such as p-nitrocatechol sulfate. Belongs to the sulfatase family. | 0.915 |
Arsa | Arsj | ENSMUSP00000127646 | ENSMUSP00000091511 | Arylsulfatase A; Hydrolyzes cerebroside sulfate. Belongs to the sulfatase family. | Arylsulfatase J. | 0.615 |
Arsa | Arsk | ENSMUSP00000127646 | ENSMUSP00000113274 | Arylsulfatase A; Hydrolyzes cerebroside sulfate. Belongs to the sulfatase family. | Arylsulfatase K. | 0.634 |
Arsa | Med14 | ENSMUSP00000127646 | ENSMUSP00000094239 | Arylsulfatase A; Hydrolyzes cerebroside sulfate. Belongs to the sulfatase family. | Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). | 0.846 |
Arsa | Med17 | ENSMUSP00000127646 | ENSMUSP00000034411 | Arylsulfatase A; Hydrolyzes cerebroside sulfate. Belongs to the sulfatase family. | Mediator of RNA polymerase II transcription subunit 17; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). | 0.602 |
Arsa | Med6 | ENSMUSP00000127646 | ENSMUSP00000125156 | Arylsulfatase A; Hydrolyzes cerebroside sulfate. Belongs to the sulfatase family. | Mediator of RNA polymerase II transcription subunit 6; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). | 0.823 |
Arsa | Sumf1 | ENSMUSP00000127646 | ENSMUSP00000032191 | Arylsulfatase A; Hydrolyzes cerebroside sulfate. Belongs to the sulfatase family. | Formylglycine-generating enzyme; Oxidase that catalyzes the conversion of cysteine to 3- oxoalanine on target proteins, using molecular oxygen and an unidentified reducing agent. 3-oxoalanine modification, which is also named formylglycine (fGly), occurs in the maturation of arylsulfatases and some alkaline phosphatases that use the hydrated form of 3- oxoalanine as a catalytic nucleophile. Known substrates include GALNS, ARSA, STS and ARSE; Belongs to the sulfatase-modifying factor family. | 0.900 |
Arsa | Sumf2 | ENSMUSP00000127646 | ENSMUSP00000126036 | Arylsulfatase A; Hydrolyzes cerebroside sulfate. Belongs to the sulfatase family. | Inactive C-alpha-formylglycine-generating enzyme 2; Lacks formylglycine generating activity and is unable to convert newly synthesized inactive sulfatases to their active form. Inhibits the activation of sulfatases by SUMF1. Belongs to the sulfatase-modifying factor family. | 0.776 |
Arsg | Arsa | ENSMUSP00000020928 | ENSMUSP00000127646 | Arylsulfatase G; Displays arylsulfatase activity with pseudosubstrates at acidic pH, such as p-nitrocatechol sulfate. Belongs to the sulfatase family. | Arylsulfatase A; Hydrolyzes cerebroside sulfate. Belongs to the sulfatase family. | 0.915 |
Arsg | Arsj | ENSMUSP00000020928 | ENSMUSP00000091511 | Arylsulfatase G; Displays arylsulfatase activity with pseudosubstrates at acidic pH, such as p-nitrocatechol sulfate. Belongs to the sulfatase family. | Arylsulfatase J. | 0.651 |
Arsg | Arsk | ENSMUSP00000020928 | ENSMUSP00000113274 | Arylsulfatase G; Displays arylsulfatase activity with pseudosubstrates at acidic pH, such as p-nitrocatechol sulfate. Belongs to the sulfatase family. | Arylsulfatase K. | 0.635 |
Arsg | Med14 | ENSMUSP00000020928 | ENSMUSP00000094239 | Arylsulfatase G; Displays arylsulfatase activity with pseudosubstrates at acidic pH, such as p-nitrocatechol sulfate. Belongs to the sulfatase family. | Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). | 0.846 |
Arsg | Med17 | ENSMUSP00000020928 | ENSMUSP00000034411 | Arylsulfatase G; Displays arylsulfatase activity with pseudosubstrates at acidic pH, such as p-nitrocatechol sulfate. Belongs to the sulfatase family. | Mediator of RNA polymerase II transcription subunit 17; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). | 0.602 |
Arsg | Med6 | ENSMUSP00000020928 | ENSMUSP00000125156 | Arylsulfatase G; Displays arylsulfatase activity with pseudosubstrates at acidic pH, such as p-nitrocatechol sulfate. Belongs to the sulfatase family. | Mediator of RNA polymerase II transcription subunit 6; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). | 0.823 |
Arsg | Sumf1 | ENSMUSP00000020928 | ENSMUSP00000032191 | Arylsulfatase G; Displays arylsulfatase activity with pseudosubstrates at acidic pH, such as p-nitrocatechol sulfate. Belongs to the sulfatase family. | Formylglycine-generating enzyme; Oxidase that catalyzes the conversion of cysteine to 3- oxoalanine on target proteins, using molecular oxygen and an unidentified reducing agent. 3-oxoalanine modification, which is also named formylglycine (fGly), occurs in the maturation of arylsulfatases and some alkaline phosphatases that use the hydrated form of 3- oxoalanine as a catalytic nucleophile. Known substrates include GALNS, ARSA, STS and ARSE; Belongs to the sulfatase-modifying factor family. | 0.808 |
Arsg | Sumf2 | ENSMUSP00000020928 | ENSMUSP00000126036 | Arylsulfatase G; Displays arylsulfatase activity with pseudosubstrates at acidic pH, such as p-nitrocatechol sulfate. Belongs to the sulfatase family. | Inactive C-alpha-formylglycine-generating enzyme 2; Lacks formylglycine generating activity and is unable to convert newly synthesized inactive sulfatases to their active form. Inhibits the activation of sulfatases by SUMF1. Belongs to the sulfatase-modifying factor family. | 0.664 |
Arsj | Abcc6 | ENSMUSP00000091511 | ENSMUSP00000002850 | Arylsulfatase J. | Multidrug resistance-associated protein 6; May participate directly in the active transport of drugs into subcellular organelles or influence drug distribution indirectly. Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. | 0.617 |
Arsj | Arsa | ENSMUSP00000091511 | ENSMUSP00000127646 | Arylsulfatase J. | Arylsulfatase A; Hydrolyzes cerebroside sulfate. Belongs to the sulfatase family. | 0.615 |