node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ankle2 | Tmem41b | ENSMUSP00000143044 | ENSMUSP00000091641 | Ankyrin repeat and LEM domain-containing protein 2; Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit. Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly. It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex (By similarity). Belongs to the ANKLE2 family. | Transmembrane protein 41B; Required for normal motor neuron development. Required for autophagosome formation; Belongs to the TMEM41 family. | 0.461 |
Atg2a | Rusc2 | ENSMUSP00000046412 | ENSMUSP00000095710 | Autophagy-related protein 2 homolog A; Involved in autophagosome assembly, regulating the size of nascent autophagosomes. Also regulates lipid droplets morphology and distribution within the cell; Belongs to the ATG2 family. | Iporin. | 0.406 |
Atg2a | Tmem41b | ENSMUSP00000046412 | ENSMUSP00000091641 | Autophagy-related protein 2 homolog A; Involved in autophagosome assembly, regulating the size of nascent autophagosomes. Also regulates lipid droplets morphology and distribution within the cell; Belongs to the ATG2 family. | Transmembrane protein 41B; Required for normal motor neuron development. Required for autophagosome formation; Belongs to the TMEM41 family. | 0.495 |
Atg2a | Vmp1 | ENSMUSP00000046412 | ENSMUSP00000018315 | Autophagy-related protein 2 homolog A; Involved in autophagosome assembly, regulating the size of nascent autophagosomes. Also regulates lipid droplets morphology and distribution within the cell; Belongs to the ATG2 family. | Vacuole membrane protein 1; Stress-induced protein that, when overexpressed, promotes formation of intracellular vacuoles followed by cell death (By similarity). May be involved in the cytoplasmic vacuolization of acinar cells during the early stage of acute pancreatitis. Involved in cell-cell adhesion. Plays an essential role in formation of cell junctions. Plays a role in the initial stages of the autophagic process through its interaction with BECN1. Required for autophagosome formation (By similarity); Belongs to the VMP1 family. | 0.586 |
BC024978 | Tmem41b | ENSMUSP00000137189 | ENSMUSP00000091641 | cDNA sequence BC024978. | Transmembrane protein 41B; Required for normal motor neuron development. Required for autophagosome formation; Belongs to the TMEM41 family. | 0.461 |
Cystm1 | Tmem41b | ENSMUSP00000158346 | ENSMUSP00000091641 | Cysteine-rich and transmembrane domain-containing protein 1. | Transmembrane protein 41B; Required for normal motor neuron development. Required for autophagosome formation; Belongs to the TMEM41 family. | 0.566 |
Rusc2 | Atg2a | ENSMUSP00000095710 | ENSMUSP00000046412 | Iporin. | Autophagy-related protein 2 homolog A; Involved in autophagosome assembly, regulating the size of nascent autophagosomes. Also regulates lipid droplets morphology and distribution within the cell; Belongs to the ATG2 family. | 0.406 |
Rusc2 | Tmem41b | ENSMUSP00000095710 | ENSMUSP00000091641 | Iporin. | Transmembrane protein 41B; Required for normal motor neuron development. Required for autophagosome formation; Belongs to the TMEM41 family. | 0.497 |
Tmem106b | Tmem41b | ENSMUSP00000031556 | ENSMUSP00000091641 | Transmembrane protein 106B; Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with MAP6. May act by inhibiting retrograde transport of lysosomes along dendrites. Required for dendrite branching (By similarity). | Transmembrane protein 41B; Required for normal motor neuron development. Required for autophagosome formation; Belongs to the TMEM41 family. | 0.482 |
Tmem251 | Tmem41b | ENSMUSP00000054611 | ENSMUSP00000091641 | Transmembrane protein 251. | Transmembrane protein 41B; Required for normal motor neuron development. Required for autophagosome formation; Belongs to the TMEM41 family. | 0.544 |
Tmem41b | Ankle2 | ENSMUSP00000091641 | ENSMUSP00000143044 | Transmembrane protein 41B; Required for normal motor neuron development. Required for autophagosome formation; Belongs to the TMEM41 family. | Ankyrin repeat and LEM domain-containing protein 2; Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit. Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly. It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex (By similarity). Belongs to the ANKLE2 family. | 0.461 |
Tmem41b | Atg2a | ENSMUSP00000091641 | ENSMUSP00000046412 | Transmembrane protein 41B; Required for normal motor neuron development. Required for autophagosome formation; Belongs to the TMEM41 family. | Autophagy-related protein 2 homolog A; Involved in autophagosome assembly, regulating the size of nascent autophagosomes. Also regulates lipid droplets morphology and distribution within the cell; Belongs to the ATG2 family. | 0.495 |
Tmem41b | BC024978 | ENSMUSP00000091641 | ENSMUSP00000137189 | Transmembrane protein 41B; Required for normal motor neuron development. Required for autophagosome formation; Belongs to the TMEM41 family. | cDNA sequence BC024978. | 0.461 |
Tmem41b | Cystm1 | ENSMUSP00000091641 | ENSMUSP00000158346 | Transmembrane protein 41B; Required for normal motor neuron development. Required for autophagosome formation; Belongs to the TMEM41 family. | Cysteine-rich and transmembrane domain-containing protein 1. | 0.566 |
Tmem41b | Rusc2 | ENSMUSP00000091641 | ENSMUSP00000095710 | Transmembrane protein 41B; Required for normal motor neuron development. Required for autophagosome formation; Belongs to the TMEM41 family. | Iporin. | 0.497 |
Tmem41b | Tmem106b | ENSMUSP00000091641 | ENSMUSP00000031556 | Transmembrane protein 41B; Required for normal motor neuron development. Required for autophagosome formation; Belongs to the TMEM41 family. | Transmembrane protein 106B; Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with MAP6. May act by inhibiting retrograde transport of lysosomes along dendrites. Required for dendrite branching (By similarity). | 0.482 |
Tmem41b | Tmem251 | ENSMUSP00000091641 | ENSMUSP00000054611 | Transmembrane protein 41B; Required for normal motor neuron development. Required for autophagosome formation; Belongs to the TMEM41 family. | Transmembrane protein 251. | 0.544 |
Tmem41b | Vmp1 | ENSMUSP00000091641 | ENSMUSP00000018315 | Transmembrane protein 41B; Required for normal motor neuron development. Required for autophagosome formation; Belongs to the TMEM41 family. | Vacuole membrane protein 1; Stress-induced protein that, when overexpressed, promotes formation of intracellular vacuoles followed by cell death (By similarity). May be involved in the cytoplasmic vacuolization of acinar cells during the early stage of acute pancreatitis. Involved in cell-cell adhesion. Plays an essential role in formation of cell junctions. Plays a role in the initial stages of the autophagic process through its interaction with BECN1. Required for autophagosome formation (By similarity); Belongs to the VMP1 family. | 0.774 |
Tmem41b | Wdr46 | ENSMUSP00000091641 | ENSMUSP00000025170 | Transmembrane protein 41B; Required for normal motor neuron development. Required for autophagosome formation; Belongs to the TMEM41 family. | WD repeat-containing protein 46; Scaffold component of the nucleolar structure. Required for localization of DDX21 and NCL to the granular compartment of the nucleolus. | 0.766 |
Tmem41b | Zfp830 | ENSMUSP00000091641 | ENSMUSP00000056154 | Transmembrane protein 41B; Required for normal motor neuron development. Required for autophagosome formation; Belongs to the TMEM41 family. | Zinc finger protein 830; May play a role in pre-mRNA splicing as component of the spliceosome (By similarity). Acts as an important regulator of the cell cycle that participates in the maintenance of genome integrity. During cell cycle progression in embryonic fibroblast, prevents replication fork collapse, double-strand break formation and cell cycle checkpoint activation. Controls mitotic cell cycle progression and cell survival in rapidly proliferating intestinal epithelium and embryonic stem cells. During the embryo preimplantation, controls different aspects of M phase. During ear [...] | 0.470 |