node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Adprh | Art1 | ENSMUSP00000002923 | ENSMUSP00000033300 | [Protein ADP-ribosylarginine] hydrolase; Specifically acts as a arginine mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to arginine residues on proteins. | GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1; Has ADP-ribosyltransferase activity toward GLP1R. Belongs to the Arg-specific ADP-ribosyltransferase family. | 0.525 |
Adprh | Art5 | ENSMUSP00000002923 | ENSMUSP00000102550 | [Protein ADP-ribosylarginine] hydrolase; Specifically acts as a arginine mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to arginine residues on proteins. | Ecto-ADP-ribosyltransferase 5; Belongs to the Arg-specific ADP-ribosyltransferase family. | 0.554 |
Adprh | Macrod1 | ENSMUSP00000002923 | ENSMUSP00000039507 | [Protein ADP-ribosylarginine] hydrolase; Specifically acts as a arginine mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to arginine residues on proteins. | ADP-ribose glycohydrolase MACROD1; Removes ADP-ribose from asparatate and glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. Plays a role in estrogen signaling. Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen. May play an important role in carcinogenesis and/or progression of hormone-dependent cancers by feed- forward [...] | 0.428 |
Adprh | Macrod2 | ENSMUSP00000002923 | ENSMUSP00000105691 | [Protein ADP-ribosylarginine] hydrolase; Specifically acts as a arginine mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to arginine residues on proteins. | ADP-ribose glycohydrolase MACROD2; Removes ADP-ribose from asparatate and glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. | 0.441 |
Adprh | Trim72 | ENSMUSP00000002923 | ENSMUSP00000101855 | [Protein ADP-ribosylarginine] hydrolase; Specifically acts as a arginine mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to arginine residues on proteins. | Tripartite motif-containing protein 72; Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the Ca(2+)- depen [...] | 0.602 |
Art1 | Adprh | ENSMUSP00000033300 | ENSMUSP00000002923 | GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1; Has ADP-ribosyltransferase activity toward GLP1R. Belongs to the Arg-specific ADP-ribosyltransferase family. | [Protein ADP-ribosylarginine] hydrolase; Specifically acts as a arginine mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to arginine residues on proteins. | 0.525 |
Art1 | Art5 | ENSMUSP00000033300 | ENSMUSP00000102550 | GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1; Has ADP-ribosyltransferase activity toward GLP1R. Belongs to the Arg-specific ADP-ribosyltransferase family. | Ecto-ADP-ribosyltransferase 5; Belongs to the Arg-specific ADP-ribosyltransferase family. | 0.607 |
Art1 | Macrod1 | ENSMUSP00000033300 | ENSMUSP00000039507 | GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1; Has ADP-ribosyltransferase activity toward GLP1R. Belongs to the Arg-specific ADP-ribosyltransferase family. | ADP-ribose glycohydrolase MACROD1; Removes ADP-ribose from asparatate and glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. Plays a role in estrogen signaling. Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen. May play an important role in carcinogenesis and/or progression of hormone-dependent cancers by feed- forward [...] | 0.406 |
Art1 | Parg | ENSMUSP00000033300 | ENSMUSP00000022470 | GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1; Has ADP-ribosyltransferase activity toward GLP1R. Belongs to the Arg-specific ADP-ribosyltransferase family. | Poly(ADP-ribose) glycohydrolase; Poly(ADP-ribose) glycohydrolase that degrades poly(ADP- ribose) by hydrolyzing the ribose-ribose bonds present in poly(ADP- ribose). PARG acts both as an endo- and exoglycosidase, releasing poly(ADP-ribose) of different length as well as ADP-ribose monomers. It is however unable to cleave the ester bond between the terminal ADP- ribose and ADP-ribosylated residues, leaving proteins that are mono- ADP-ribosylated. Poly(ADP-ribose) is synthesized after DNA damage is only present transiently and is rapidly degraded by PARG. Required to prevent detrimental [...] | 0.425 |
Art1 | Trim54 | ENSMUSP00000033300 | ENSMUSP00000013771 | GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1; Has ADP-ribosyltransferase activity toward GLP1R. Belongs to the Arg-specific ADP-ribosyltransferase family. | Tripartite motif-containing protein 54; May bind and stabilize microtubules during myotubes formation. | 0.598 |
Art1 | Trim72 | ENSMUSP00000033300 | ENSMUSP00000101855 | GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1; Has ADP-ribosyltransferase activity toward GLP1R. Belongs to the Arg-specific ADP-ribosyltransferase family. | Tripartite motif-containing protein 72; Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the Ca(2+)- depen [...] | 0.406 |
Art5 | Adprh | ENSMUSP00000102550 | ENSMUSP00000002923 | Ecto-ADP-ribosyltransferase 5; Belongs to the Arg-specific ADP-ribosyltransferase family. | [Protein ADP-ribosylarginine] hydrolase; Specifically acts as a arginine mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to arginine residues on proteins. | 0.554 |
Art5 | Art1 | ENSMUSP00000102550 | ENSMUSP00000033300 | Ecto-ADP-ribosyltransferase 5; Belongs to the Arg-specific ADP-ribosyltransferase family. | GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1; Has ADP-ribosyltransferase activity toward GLP1R. Belongs to the Arg-specific ADP-ribosyltransferase family. | 0.607 |
Art5 | Asb5 | ENSMUSP00000102550 | ENSMUSP00000033918 | Ecto-ADP-ribosyltransferase 5; Belongs to the Arg-specific ADP-ribosyltransferase family. | Ankyrin repeat and SOCS box protein 5; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. May play a role in the initiation of arteriogenesis (By similarity). | 0.490 |
Art5 | Gm2115 | ENSMUSP00000102550 | ENSMUSP00000148068 | Ecto-ADP-ribosyltransferase 5; Belongs to the Arg-specific ADP-ribosyltransferase family. | Cortexin domain-containing 1. | 0.516 |
Art5 | Macrod1 | ENSMUSP00000102550 | ENSMUSP00000039507 | Ecto-ADP-ribosyltransferase 5; Belongs to the Arg-specific ADP-ribosyltransferase family. | ADP-ribose glycohydrolase MACROD1; Removes ADP-ribose from asparatate and glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. Plays a role in estrogen signaling. Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen. May play an important role in carcinogenesis and/or progression of hormone-dependent cancers by feed- forward [...] | 0.640 |
Art5 | Macrod2 | ENSMUSP00000102550 | ENSMUSP00000105691 | Ecto-ADP-ribosyltransferase 5; Belongs to the Arg-specific ADP-ribosyltransferase family. | ADP-ribose glycohydrolase MACROD2; Removes ADP-ribose from asparatate and glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. | 0.601 |
Art5 | Parg | ENSMUSP00000102550 | ENSMUSP00000022470 | Ecto-ADP-ribosyltransferase 5; Belongs to the Arg-specific ADP-ribosyltransferase family. | Poly(ADP-ribose) glycohydrolase; Poly(ADP-ribose) glycohydrolase that degrades poly(ADP- ribose) by hydrolyzing the ribose-ribose bonds present in poly(ADP- ribose). PARG acts both as an endo- and exoglycosidase, releasing poly(ADP-ribose) of different length as well as ADP-ribose monomers. It is however unable to cleave the ester bond between the terminal ADP- ribose and ADP-ribosylated residues, leaving proteins that are mono- ADP-ribosylated. Poly(ADP-ribose) is synthesized after DNA damage is only present transiently and is rapidly degraded by PARG. Required to prevent detrimental [...] | 0.563 |
Art5 | Trim54 | ENSMUSP00000102550 | ENSMUSP00000013771 | Ecto-ADP-ribosyltransferase 5; Belongs to the Arg-specific ADP-ribosyltransferase family. | Tripartite motif-containing protein 54; May bind and stabilize microtubules during myotubes formation. | 0.558 |
Art5 | Trim72 | ENSMUSP00000102550 | ENSMUSP00000101855 | Ecto-ADP-ribosyltransferase 5; Belongs to the Arg-specific ADP-ribosyltransferase family. | Tripartite motif-containing protein 72; Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the Ca(2+)- depen [...] | 0.604 |