node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Hes2 | Hes3 | ENSMUSP00000030782 | ENSMUSP00000092006 | Transcription factor HES-2; Transcriptional repressor of genes that require a bHLH protein for their transcription. | Transcription factor HES-3; Transcriptional repressor of genes that require a bHLH protein for their transcription. | 0.655 |
Hes2 | Hey1 | ENSMUSP00000030782 | ENSMUSP00000038014 | Transcription factor HES-2; Transcriptional repressor of genes that require a bHLH protein for their transcription. | Hairy/enhancer-of-split related with YRPW motif protein 1; Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses tra [...] | 0.407 |
Hes2 | Hey2 | ENSMUSP00000030782 | ENSMUSP00000019924 | Transcription factor HES-2; Transcriptional repressor of genes that require a bHLH protein for their transcription. | Hairy/enhancer-of-split related with YRPW motif protein 2; Transcriptional repressor which functions as a downstream effector of Notch signaling in cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY1 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Represse [...] | 0.419 |
Hes2 | Rbpj | ENSMUSP00000030782 | ENSMUSP00000040694 | Transcription factor HES-2; Transcriptional repressor of genes that require a bHLH protein for their transcription. | Recombining binding protein suppressor of hairless; Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling [...] | 0.462 |
Hes3 | Hes2 | ENSMUSP00000092006 | ENSMUSP00000030782 | Transcription factor HES-3; Transcriptional repressor of genes that require a bHLH protein for their transcription. | Transcription factor HES-2; Transcriptional repressor of genes that require a bHLH protein for their transcription. | 0.655 |
Hes3 | Hes6 | ENSMUSP00000092006 | ENSMUSP00000084062 | Transcription factor HES-3; Transcriptional repressor of genes that require a bHLH protein for their transcription. | Transcription cofactor HES-6; Does not bind DNA itself but suppresses both HES1-mediated N box-dependent transcriptional repression and binding of HES1 to E box sequences. Also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/MASH1 and TCF3/E47, allowing ASCL1 and TCF3 to up- regulate transcription in its presence. Promotes cell differentiation. | 0.569 |
Hes3 | Hey1 | ENSMUSP00000092006 | ENSMUSP00000038014 | Transcription factor HES-3; Transcriptional repressor of genes that require a bHLH protein for their transcription. | Hairy/enhancer-of-split related with YRPW motif protein 1; Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses tra [...] | 0.580 |
Hes3 | Hey2 | ENSMUSP00000092006 | ENSMUSP00000019924 | Transcription factor HES-3; Transcriptional repressor of genes that require a bHLH protein for their transcription. | Hairy/enhancer-of-split related with YRPW motif protein 2; Transcriptional repressor which functions as a downstream effector of Notch signaling in cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY1 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Represse [...] | 0.616 |
Hes3 | Heyl | ENSMUSP00000092006 | ENSMUSP00000040576 | Transcription factor HES-3; Transcriptional repressor of genes that require a bHLH protein for their transcription. | Hairy/enhancer-of-split related with YRPW motif-like protein; Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3' (By similarity). Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6. | 0.620 |
Hes3 | Mixl1 | ENSMUSP00000092006 | ENSMUSP00000027778 | Transcription factor HES-3; Transcriptional repressor of genes that require a bHLH protein for their transcription. | Homeobox protein MIXL1; Transcription factor that play a central role in proper axial mesendoderm morphogenesis and endoderm formation. Required for efficient differentiation of cells from the primitive streak stage to blood, by acting early in the recruitment and/or expansion of mesodermal progenitors to the hemangioblastic and hematopoietic lineages. Also involved in the morphogenesis of the heart and the gut during embryogenesis. Acts as a negative regulator of brachyury expression. | 0.491 |
Hes3 | Notch1 | ENSMUSP00000092006 | ENSMUSP00000028288 | Transcription factor HES-3; Transcriptional repressor of genes that require a bHLH protein for their transcription. | Neurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...] | 0.485 |
Hes3 | Pax6 | ENSMUSP00000092006 | ENSMUSP00000087870 | Transcription factor HES-3; Transcriptional repressor of genes that require a bHLH protein for their transcription. | Paired box protein Pax-6; Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells. Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). | 0.470 |
Hes3 | Rbpj | ENSMUSP00000092006 | ENSMUSP00000040694 | Transcription factor HES-3; Transcriptional repressor of genes that require a bHLH protein for their transcription. | Recombining binding protein suppressor of hairless; Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling [...] | 0.538 |
Hes3 | Spata31d1b | ENSMUSP00000092006 | ENSMUSP00000130813 | Transcription factor HES-3; Transcriptional repressor of genes that require a bHLH protein for their transcription. | Spermatogenesis-associated 31 subfamily D, member 1B. | 0.538 |
Hes6 | Hes3 | ENSMUSP00000084062 | ENSMUSP00000092006 | Transcription cofactor HES-6; Does not bind DNA itself but suppresses both HES1-mediated N box-dependent transcriptional repression and binding of HES1 to E box sequences. Also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/MASH1 and TCF3/E47, allowing ASCL1 and TCF3 to up- regulate transcription in its presence. Promotes cell differentiation. | Transcription factor HES-3; Transcriptional repressor of genes that require a bHLH protein for their transcription. | 0.569 |
Hes6 | Heyl | ENSMUSP00000084062 | ENSMUSP00000040576 | Transcription cofactor HES-6; Does not bind DNA itself but suppresses both HES1-mediated N box-dependent transcriptional repression and binding of HES1 to E box sequences. Also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/MASH1 and TCF3/E47, allowing ASCL1 and TCF3 to up- regulate transcription in its presence. Promotes cell differentiation. | Hairy/enhancer-of-split related with YRPW motif-like protein; Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3' (By similarity). Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6. | 0.408 |
Hes6 | Notch1 | ENSMUSP00000084062 | ENSMUSP00000028288 | Transcription cofactor HES-6; Does not bind DNA itself but suppresses both HES1-mediated N box-dependent transcriptional repression and binding of HES1 to E box sequences. Also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/MASH1 and TCF3/E47, allowing ASCL1 and TCF3 to up- regulate transcription in its presence. Promotes cell differentiation. | Neurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...] | 0.530 |
Hes6 | Rbpj | ENSMUSP00000084062 | ENSMUSP00000040694 | Transcription cofactor HES-6; Does not bind DNA itself but suppresses both HES1-mediated N box-dependent transcriptional repression and binding of HES1 to E box sequences. Also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/MASH1 and TCF3/E47, allowing ASCL1 and TCF3 to up- regulate transcription in its presence. Promotes cell differentiation. | Recombining binding protein suppressor of hairless; Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling [...] | 0.501 |
Hey1 | Hes2 | ENSMUSP00000038014 | ENSMUSP00000030782 | Hairy/enhancer-of-split related with YRPW motif protein 1; Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses tra [...] | Transcription factor HES-2; Transcriptional repressor of genes that require a bHLH protein for their transcription. | 0.407 |
Hey1 | Hes3 | ENSMUSP00000038014 | ENSMUSP00000092006 | Hairy/enhancer-of-split related with YRPW motif protein 1; Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses tra [...] | Transcription factor HES-3; Transcriptional repressor of genes that require a bHLH protein for their transcription. | 0.580 |