STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Ldlrad1Low density lipoprotein receptor class A domain-containing 1. (218 aa)    
Predicted Functional Partners:
Sntn
Sentan; May be a component of the linker structure that bridges the ciliary membrane and peripheral singlet microtubules.
   
  
 0.751
Clpb
Caseinolytic peptidase B protein homolog; May function as a regulatory ATPase and be related to secretion/protein trafficking process; Belongs to the ClpA/ClpB family.
  
 
 0.710
Shisa8
Protein shisa-8; May regulate trafficking and current kinetics of AMPA-type glutamate receptor (AMPAR) at synapses.
      
 0.665
Cfap161
Cilia- and flagella-associated protein 161; May play a role in motile cilia function, possibly by acting on dynein arm assembly.
   
 
 0.616
Grpel1
GrpE protein homolog 1, mitochondrial; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins (By similarity).
  
 
 0.601
Grpel2
GrpE protein homolog 2, mitochondrial; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins. Stimulates ATPase activity of mt-HSP70. May also serve to modulate the interconversion of oligomeric (inactive) and monomeric (active) forms of mt-HSP70; Belongs to the GrpE family.
  
 
 0.601
Tmem212
Transmembrane protein 212.
  
 
 0.585
Cfap221
Cilia- and flagella-associated protein 221; May play a role in cilium morphogenesis. Belongs to the PCDP1 family.
   
    0.582
1700021F07Rik
Uncharacterized protein C20orf85 homolog.
   
    0.580
Lrguk
Leucine-rich repeat and guanylate kinase domain-containing protein; Involved in multiple aspects of sperm assembly including acrosome attachment, shaping of the sperm head and in the early aspects of axoneme development. Not essential for primary cilium biogenesis.
   
 
 0.549
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
Server load: low (24%) [HD]