STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Prdm15PR domain zinc finger protein 15; Sequence-specific DNA-binding transcriptional regulator. Plays a role as a molecular node in a transcriptional network regulating embryonic development and cell fate decision. Stimulates the expression of upstream key transcriptional activators and repressors of the Wnt/beta-catenin and MAPK/ERK pathways, respectively, that are essential for naive pluripotency and self-renewal maintenance of embryonic stem cells (ESCs). Specifically promotes SPRY1 and RSPO1 transcription activation through recognition and direct binding of a specific DNA sequence in th [...] (1174 aa)    
Predicted Functional Partners:
C2cd2
C2 domain-containing protein 2.
 
 
  
 0.712
Map3k7cl
MAP3K7 C-terminal-like protein.
    
 
 0.700
Setd4
SET domain-containing protein 4; Belongs to the class V-like SAM-binding methyltransferase superfamily. SETD4 family.
   
 
 0.667
Lca5
Lebercilin; Involved in intraflagellar protein (IFT) transport in photoreceptor cilia.
   
  
 0.665
Shisa8
Protein shisa-8; May regulate trafficking and current kinetics of AMPA-type glutamate receptor (AMPAR) at synapses.
      
 0.635
Tspear
Thrombospondin-type laminin G domain and EAR repeat-containing protein; Plays a critical role in tooth and hair follicle morphogenesis through regulation of the Notch signaling pathway. May play a role in development or function of the auditory system.
    
 
 0.602
Efcab5
EF-hand calcium-binding domain-containing protein 5.
    
 
 0.594
Ybey
Endoribonuclease YbeY; Single strand-specific metallo-endoribonuclease involved in rRNA maturation; Belongs to the endoribonuclease YbeY family.
   
  
 0.586
Cdan1
Codanin-1; May act as a negative regulator of ASF1 in chromatin assembly.
   
    0.566
Cdcp2
CUB domain-containing protein 2.
      
 0.553
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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